[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406190-105":59,"doc-detail-406190-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","liquid-biopsy-techniques-and-pancreatic-cancer-diagnosis-monitoring-and-evaluation","Liquid biopsy techniques and pancreatic cancer - diagnosis, monitoring, and evaluation","","Pancreatic cancer (PC) is a highly prevalent malignancy where most patients cannot undergo curative surgery at diagnosis. Even after surgery, metastasis during or soon after operations may occur because precise prognosis evaluation is not always feasible. Missing timely surgery often forces reliance on chemotherapy, yet resistance can severely limit outcomes. Liquid biopsy is presented as a promising noninvasive approach for diagnosis, treatment monitoring, and prognosis assessment, offering cost and convenience advantages over tissue biopsy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/liquid-biopsy-techniques-and-pancreatic-cancer-diagnosis-monitoring-and-evaluation/406190/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/liquid-biopsy-techniques-and-pancreatic-cancer-diagnosis-monitoring-and-evaluation/406190.png","ImageObject",300,407,{"name":92,"@type":93},"eBook King","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early diagnosis important in pancreatic cancer?","Question",{"text":113,"@type":114},"Most patients are unsuitable for surgical operations when diagnosed, so screening and early diagnosis are crucial to improve outcomes.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What challenges do current diagnostic methods create for patients?",{"text":118,"@type":114},"Endoscopic ultrasonography-guided procedures, imaging, and repeated examinations can be invasive, costly, involve radiation exposure, and increase patient burden.",{"name":120,"@type":111,"acceptedAnswer":121},"How does liquid biopsy support clinical management of pancreatic cancer?",{"text":122,"@type":114},"Liquid biopsy provides noninvasive information for molecular understanding of tumor occurrence and development, enabling more precise and personalized decisions for diagnosis, monitoring response, resistance assessment, and prognosis evaluation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406190,1790823192,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Wang et al. Molecular Cancer (2023) 22:167 [https://doi.org/10.1186/s12943-023-01870-3](https://doi.org/10.1186/s12943-023-01870-3)  \nMolecular Cancer  \n REVIEW Open Access  \nLiquid biopsy techniques and pancreatic  \ncancer: diagnosis, monitoring, and evaluation  \nKangchun Wang1, Xin Wang2, Qi Pan 1* and Bei Zhao3*  \nAbstract  \nPancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a potential curative approach for PC, but most patients are unsuitable for operations when at the time of diagnosis. Even with surgery, some patients may still experience tumour metastasis during the operation or shortly after surgery, as precise prognosis evaluation is not always possible. If patients miss the opportunity for surgery and resort to chemotherapy, they may face the challenging issue of chemotherapy resistance. In recent years, liquid biopsy has shown promising prospectsin disease diagnosis, treatment monitoring, and prognosis assessment. As a noninvasive detection method, liquid biopsy offers advantages over traditional diagnostic procedures, such as tissue biopsy, in terms of both cost-effectiveness and convenience. The information provided by liquid biopsy helps clinical practitioners understand the molecular mechanisms underlying tumour occurrence and development, enabling the formulation of more precise and personalized treatment decisions for each patient. This review introduces molecular biomarkers and detection methods in liquid biopsy for PC, including circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), noncoding RNAs (ncRNAs), and extracellular vesicles (EVs) or exosomes. Additionally, we summarize the applications of liquid biopsy in the early diagnosis, treatment response, resistance assessment, and prognostic evaluation of PC.  \nKeywords Circulating tumour cells, Circulating tumour DNA, Noncoding RNAs, Extracellular vesicles, Exosomes, Pancreatic cancer, Liquid biopsy  \nIntroduction  \nPancreatic cancer (PC) is one of the most common malignancies, and the number of PC cases has doubled over the past two decades. The incidence of PC varies significantly across regions and populations, with the highest rates observed in North America, Europe, and Australia [1–3]. Recent years have seen a rapid increase in deaths  \n*Correspondence: Qi Pan [qpan@cmu.edu.cn](qpan@cmu.edu.cn)[ ](qpan@cmu.edu.cn)Bei Zhao [zhaobei95@163.com](zhaobei95@163.com)  \n1 Department of Organ Transplantation and Hepatobiliary, The First Affiliated Hospital of China Medical University, Shenyang 110001, China  \n2 Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha 410008, China  \n3 Department of Ultrasound, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China  \ndue to PC, which can be attributed to global population growth and age structure changes and is closely linked to social and economic development [4]. According to predictions, PC is expected to become the third leading cause of cancer-related deaths in the European Union [5]. By 2030, it is projected to overtake breast, prostate, and colorectal cancers and become the second leading cause of cancer-related deaths in the United States [6].  \nPancreatic ductal adenocarcinoma (PDAC) is a primary histological subtype of PC, accounting for 90% of all cases [7, 8] . Surgical resection is one of the methods of a potential cure, but most PDAC patients are unsuitable for operations when they are diagnosed [9, 10] . Therefore, screening and diagnosis should be conducted as early as possible to ensure a positive outcome. The diagnosis of PDAC relies on endoscopic ultrasonography-guided fine needle aspiration  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s","cbCaioe5NkKCLJOb","https://ap.wps.com/l/cbCaioe5NkKCLJOb","pdf",3232084,25,"English","# Abstract\n# Introduction\n## Pancreatic cancer burden and unmet needs\n## PDAC and diagnostic approaches\n## Biomarkers and limitations of current tests","[{\"question\":\"Why is early diagnosis important in pancreatic cancer?\",\"answer\":\"Most patients are unsuitable for surgical operations when diagnosed, so screening and early diagnosis are crucial to improve outcomes.\"},{\"question\":\"What challenges do current diagnostic methods create for patients?\",\"answer\":\"Endoscopic ultrasonography-guided procedures, imaging, and repeated examinations can be invasive, costly, involve radiation exposure, and increase patient burden.\"},{\"question\":\"How does liquid biopsy support clinical management of pancreatic cancer?\",\"answer\":\"Liquid biopsy provides noninvasive information for molecular understanding of tumor occurrence and development, enabling more precise and personalized decisions for diagnosis, monitoring response, resistance assessment, and prognosis evaluation.\"}]","Liquid biopsy techniques and pancreatic cancer - diagnosis, monitoring, and evaluation | PDF",1790564033,63]