[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-455652-105":59,"doc-detail-455652-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","lipid-pathways-connecting-maternal-bmi-with-infant-obesity-risk","Lipid pathways connecting maternal BMI with infant obesity risk","","Maternal obesity is a major driver of early-life health, elevating infant obesity risk, while lipids may support intergenerational transfer through fetal or infant lipid alterations. Using the Barwon Infant Study, researchers examined links among maternal pre-pregnancy BMI, maternal lipidomic profiles, human milk, and infant early growth. Ether-lipid metabolism was assessed via a composite plasmalogen score and mediation analyses. Six cord blood lipids mediated up to 18% of the pp-BMI effect on birth weight.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lipid-pathways-connecting-maternal-bmi-with-infant-obesity-risk/455652/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lipid-pathways-connecting-maternal-bmi-with-infant-obesity-risk/455652.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What relationship does the study examine between maternal BMI and infant obesity risk?","Question",{"text":112,"@type":113},"It investigates how maternal pre-pregnancy BMI is associated with infant obesity-related indicators through lipid profiles across mother, cord, milk, and early growth.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are ether lipids and plasmalogen scores central to the study?",{"text":117,"@type":113},"Ether lipids are abundant in human milk, linked to breastfeeding, and involved in metabolism and inflammation. The study uses a composite plasmalogen score to reflect ether-lipid metabolism.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the mediation analysis show about cord blood lipids?",{"text":121,"@type":113},"Six cord blood lipids mediated up to 18% of the effect of maternal pre-pregnancy BMI on birth weight.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455652,1790889255,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nLipid pathways connecting maternal BMI with infant obesity risk  \nAlexandra D. George1,2,3,10􀀍, Tingting Wang1,2,10, Thy Duong1, Yvette Schooneveldt1, Sudip Paul1,3, Gavriel Olshansky1, Toby Mansell4,5, Richard Saffery4,5, Peter Vuillermin4,6,7, Anne-Louise Ponsonby4,8, David Burgner4,5, Barwon Infant Study Investigator Group, Satvika Burugupalli1,2,10 & Peter J. Meikle1,2,3,9,10􀀍  \nMaternal obesity is a key determinant of infant health, increasing early-life obesity risk. Lipids are mechanistically linked to obesity and may mediate intergenerational transfer, by influencing foetal or infant lipids. Using the Barwon Infant Study, we investigated associations between maternal pre-pregnancy body mass index (pp-BMI), lipidomic profiles of mothers, human milk, and infants, and early life growth. Ether lipids were of particular interest due to their abundance in human milk, association with breastfeeding, and roles in metabolism and inflammation. Linear regression analyses assessed relationships between maternal pp-BMI and lipid profiles across biospecimens, and infant  \nBMI. A composite plasmalogen score, reflecting ether lipid metabolism, was developed due to its strong associations with pp-BMI and breastfeeding. Mediation analysis assessed if cord lipids mediated the effect of pp-BMI on birth weight. Maternal pp-BMI was significantly associated with maternal and cord lipids, and obesity risk indicators. Six cord blood lipids mediated up to 18% of the effect of pp-BMI on birth weight. Maternal plasmalogen score was negatively associated with pp-BMI and positively associated with human milk and infant plasmalogen scores from birth to four years of age. Infant plasmalogen score at six months was inversely associated with BMI z-score at four years of age. These findings suggest that ether lipids may be modifiable biomarkers of metabolic programming and intervention targets to reduce obesity risk in early life.  \nKeywords Lipid, DOHaD, Metabolic programming  \nThe prevalence of overweight and obesity in children has reached alarming levels, affecting approximately one in four Australian children1. Contributing to this public health issue, maternal overweight and obesity are significant risk factors for infant obesity2. Maternal pre-conception obesity increases the odds of childhood obesity by up to 264%3 and maternal pre-pregnancy body mass index (pp-BMI) is associated with infant birth weight, BMI and overweight status4,5. Furthermore, high gestational weight gain is associated with increased infant BMI and obesity risk in adulthood6. These findings suggest that a healthy maternal metabolic status before and during pregnancy may contribute to favourable metabolic programming and reduced obesity risk for the infant, although the underlying biology remains poorly defined.  \nThe role of lipids and lipid metabolism, known to be critical in metabolic health, has been largely overlooked in early life studies. Circulating lipids are known to have critical roles in health and disease and may be involved in health programming7–9. Adult obesity is associated with lipid dysregulation8, and during pregnancy, a time of high metabolic activity, many circulating lipids are elevated7. The circulating lipid profile in infancy changes across early life as metabolism develops, and previous studies have reported links between circulating lipids  \n1Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. 2Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, Australia. 3Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, Australia. 4Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, VIC, Australia. 5Department of Pediatrics, University of Melbourne, Parkville, VIC, Australia. 6School of Medicine, Deakin University, Melbourne, VIC, Aust","cbCaif9q5dHmJ5dm","https://ap.wps.com/l/cbCaif9q5dHmJ5dm","pdf",2916107,"English","# Introduction\n# Methods and analytic approach\n# Results\n## Maternal and cord lipid mediation\n# Discussion and implications","[{\"question\":\"What relationship does the study examine between maternal BMI and infant obesity risk?\",\"answer\":\"It investigates how maternal pre-pregnancy BMI is associated with infant obesity-related indicators through lipid profiles across mother, cord, milk, and early growth.\"},{\"question\":\"Why are ether lipids and plasmalogen scores central to the study?\",\"answer\":\"Ether lipids are abundant in human milk, linked to breastfeeding, and involved in metabolism and inflammation. The study uses a composite plasmalogen score to reflect ether-lipid metabolism.\"},{\"question\":\"What did the mediation analysis show about cord blood lipids?\",\"answer\":\"Six cord blood lipids mediated up to 18% of the effect of maternal pre-pregnancy BMI on birth weight.\"}]","Lipid pathways connecting maternal BMI with infant obesity risk | PDF",1790743762,25]