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Cancer metabolism reprogramming is central to survival, and lipid metabolism reprogramming is implicated in tumorigenesis, invasion, metastasis, therapeutic resistance, and immune modulation. This review consolidates how aberrant lipid pathways and transcriptional regulation drive oncogenesis and progression. It also proposes targeted lipid-metabolism strategies aimed at sensitizing immunotherapy and enhancing hormone therapy, potentially improving options for advanced or metastatic disease.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lipid-metabolism-reprogramming-in-endometrial-cancer-biological-functions-and-therapeutic-implications-review/331269/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lipid-metabolism-reprogramming-in-endometrial-cancer-biological-functions-and-therapeutic-implications-review/331269.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What relationship does the review describe between endometrial cancer and metabolic factors?","Question",{"text":113,"@type":114},"It highlights associations with obesity and dyslipidemia and frames endometrial cancer as metabolism-disorder related, linking metabolic stress to disease development and progression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancer processes are connected to lipid metabolism reprogramming in endometrial cancer?",{"text":118,"@type":114},"The review links lipid metabolism reprogramming to tumorigenesis, invasiveness, metastasis, therapeutic resistance, and immune modulation.",{"name":120,"@type":111,"acceptedAnswer":121},"What therapeutic strategies does the review propose?",{"text":122,"@type":114},"It proposes targeting lipid metabolism pathways, including approaches that may sensitize immunotherapy and complement hormone therapy for advanced or metastatic endometrial cancer.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331269,1790193425,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Wang et al. Cell Communication and Signaling (2024) 22:436  \n[https://doi.org/10.1186/s12964-024-01792-7](https://doi.org/10.1186/s12964-024-01792-7)  \nCell Communication and Signaling  \n REVIEW Open Access  \nLipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications  \nXiangyu Wang1, Yinuo Li1, Xin Hou1, Jingfang Li 1 and Xiangyi Ma 1*  \nAbstract  \nBackground Endometrial cancer is one of the major gynecological cancers, with increasing incidence and mortality in the past decades. Emerging preclinical and clinical data have indicated its close association with obesity and dyslipidemia. Metabolism reprogramming has been considered as the hallmark of cancer, to satisfy the extensive need of nutrients and energy for survival and growth. Particularly, lipid metabolism reprogramming has aroused the researchers’ interest in the field of cancer, including tumorigenesis, invasiveness, metastasis, therapeutic resistance and immunity modulation, etc. But the roles of lipid metabolism reprogramming in endometrial cancer have not been fully understood. This review has summarized how lipid metabolism reprogramming induces oncogenesisand progression of endometrial cancer, including the biological functions of aberrant lipid metabolism pathway and altered transcription regulation of lipid metabolism pathway. Besides, we proposed novel therapeutic strategies of targeting lipid metabolism pathway and concentrated on its potential of sensitizing immunotherapy and hormonal therapy, to further optimize the existing treatment modalities of patients with advanced/metastatic endometrial cancer. Moreover, we expect that targeting lipid metabolism plus hormone therapy may block the endometrial malignant transformation and enrich the preventative approaches of endometrial cancer.  \nConclusion Lipid metabolism reprogramming plays an important role in tumor initiation and cancer progression of endometrial cancer. Targeting the core enzymes and transcriptional factors of lipid metabolism pathway alone or in combination with immunotherapy/hormone treatment is expected to decrease the tumor burden and provide promising treatment opportunity for patients with advanced/metastatic endometrial cancer.  \nKeywords Endometrial cancer, Lipid metabolism reprogramming, Tumorigenesis, Cancer progression, Targeted therapy  \nBackground  \nEndometrial cancer (EC) has become one of the most prevalent gynecological malignancies with 420, 242 newly diagnosed and 97,704 death patients worldwide  \n*Correspondence: Xiangyi Ma[xyma@tjh.tjmu.edu.cn](xyma@tjh.tjmu.edu.cn)  \n1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province 430030, China  \n[1]. Due to lifestyle risk factors like obesity and the lacking of treatment advancement, the incidence and mortality of EC have continued to rise for decades, directly threatening females’health and survival [2, 3]. Surgery alone or combined with radiation and/or platinum-based chemotherapy as well as hormone therapy can generate good efficacy in most EC patients [4]. However, the 5-year survival rates of patients with stage III/IV tumors remain only 48% and 15% respectively [5]. What’s worse, the median overall survival (OS) of recurrent/metastatic patient is extremely short, ranging from 12 to 15 months  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party","cbCailOoqEqmUl2X","https://ap.wps.com/l/cbCailOoqEqmUl2X","pdf",1823496,"English","# Abstract\n## Background\n## Conclusion","[{\"question\":\"What relationship does the review describe between endometrial cancer and metabolic factors?\",\"answer\":\"It highlights associations with obesity and dyslipidemia and frames endometrial cancer as metabolism-disorder related, linking metabolic stress to disease development and progression.\"},{\"question\":\"Which cancer processes are connected to lipid metabolism reprogramming in endometrial cancer?\",\"answer\":\"The review links lipid metabolism reprogramming to tumorigenesis, invasiveness, metastasis, therapeutic resistance, and immune modulation.\"},{\"question\":\"What therapeutic strategies does the review propose?\",\"answer\":\"It proposes targeting lipid metabolism pathways, including approaches that may sensitize immunotherapy and complement hormone therapy for advanced or metastatic endometrial cancer.\"}]","Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications - Review | PDF",1789992485,48]