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Findings describe chemotherapy-associated shifts in lipid markers, dose-regimen differences, and associations between baseline and persistent dyslipidemia and clinical endpoints, including relapse risk and disease-free survival. The review also discusses potential roles for lipid-lowering therapies and highlights ongoing research needs.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/lipid-metabolism-and-breast-cancer-a-narrative-review-of-the-prognostic-implications-and-chemotherapy-induced-dyslipidemia-read-online-free/361870/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/lipid-metabolism-and-breast-cancer-a-narrative-review-of-the-prognostic-implications-and-chemotherapy-induced-dyslipidemia-read-online-free/361870.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does chemotherapy affect lipid profiles in breast cancer patients?","Question",{"text":63,"@type":64},"Chemotherapy can significantly increase triglycerides, TC, and LDL-C while decreasing HDL-C. Reported HDL-C changes include a reduction from about 1.1 to 0.9 mmol/L, with higher dyslipidemia incidence after treatment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which chemotherapy regimens show the strongest lipid-altering effects?",{"text":68,"@type":64},"Lipid alterations are described as most pronounced with anthracycline- and taxane-based regimens, associated with substantial rises in triglycerides and reductions in HDL-C.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the prognostic significance of lipid changes?",{"text":72,"@type":64},"Higher baseline HDL-C is linked to better chemotherapy response, while elevated triglycerides and LDL-C correlate with greater tumor aggressiveness and higher relapse risk. 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Lipid Metabolism and Breast Cancer: A Narrative Review of the Prognostic Implications and Chemotherapy-Induced Dyslipidemia. Life 2025, 15, 689 . [https://doi.org/10.3390/life15050689](https://doi.org/10.3390/life15050689)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 IInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania;  \nflaviu.faur@umft.ro (I.F.F.); dobrescu.amadeus@umft.ro (A.D.); paul.pasca@umft.ro (P.P.);  \n[marian.marco@umft.ro](marian.marco@umft.ro) (M.M.); [brebu.dan@umft.ro](brebu.dan@umft.ro) (D.B.); [braicu.vlad@umft.ro](braicu.vlad@umft.ro) (V.B.);  \n[duta.ciprian@umft.ro](duta.ciprian@umft.ro) (C.D.)  \n2 X Department of General Surgery,“Victor Babes” University of Medicine and Pharmacy Timisoara,  \n300041 Timisoara, Romania  \n3 Multidisciplinary Doctoral School,“Vasile Goldis,”Western University of Arad, 310025 Arad, Romania  \n4 Doctoral School of Medicine,“Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania  \n5 Faculty of Medicine,“Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square  \n2, 300041 Timisoara, Romania; [mihai.burta@student.umft.ro](mihai.burta@student.umft.ro) (C.B.); [talpai.tamas@umft.ro](talpai.tamas@umft.ro) (T.T.)  \n6 Faculty of Pharmacy,“Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq., Nr. 2, 300041 Timisoara, Romania; [andreea.neamtu@umft.ro](andreea.neamtu@umft.ro)  \n7 IIIrd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania  \n8 Ist Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania; [totolici.bogdan@uvvg.ro](totolici.bogdan@uvvg.ro)  \n9 Department of General Surgery, Faculty of Medicine,“Vasile Goldis,”Western University of Arad,  \n310025 Arad, Romania  \n* Correspondence: [adelina.clim@umft.ro](adelina.clim@umft.ro)  \nAbstract: Introduction: Lipid metabolism plays a crucial role in breast cancer’s progression, treatment response, and prognosis. Alterations in triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) have been implicated in tumor aggressiveness and chemotherapy outcomes. This review examines the relationship between dyslipidemia and breast cancer, with a focus on chemotherapyinduced lipid alterations and their prognostic significance. Methods: A comprehensive literature search was conducted in PUBMED, Web of Science, and Google Scholar, identifying 108 unique studies. After applying the inclusion criteria, 21 studies were selected for analysis, covering lipid profile changes before, during, and after chemotherapy, as well as their impact on treatment response and clinical outcomes. Results: Breast cancer patients exhibited lower baseline TC, TG, and LDL-C levels compared to healthy controls; however, chemotherapy significantly increased these markers while decreasing HDL-C from 1.1 to 0.9 mmol/L. The incidence of dyslipidemia rose from 42.98% pre-","cbCaisGdEFsPUUA4","https://ap.wps.com/l/cbCaisGdEFsPUUA4","pdf",429105,13,"English","# Abstract\n# Introduction\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"How does chemotherapy affect lipid profiles in breast cancer patients?\",\"answer\":\"Chemotherapy can significantly increase triglycerides, TC, and LDL-C while decreasing HDL-C. Reported HDL-C changes include a reduction from about 1.1 to 0.9 mmol/L, with higher dyslipidemia incidence after treatment.\"},{\"question\":\"Which chemotherapy regimens show the strongest lipid-altering effects?\",\"answer\":\"Lipid alterations are described as most pronounced with anthracycline- and taxane-based regimens, associated with substantial rises in triglycerides and reductions in HDL-C.\"},{\"question\":\"What is the prognostic significance of lipid changes?\",\"answer\":\"Higher baseline HDL-C is linked to better chemotherapy response, while elevated triglycerides and LDL-C correlate with greater tumor aggressiveness and higher relapse risk. Persistently high post-treatment triglycerides are associated with worse disease-free survival.\"}]","Lipid Metabolism and Breast Cancer: A Narrative Review of the Prognostic Implications and Chemotherapy-Induced Dyslipidemia - read online free | PDF",1790145847,33]