[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-113768-en":3,"doc-seo-113768-105":30,"detail-sidebar-cat-0-en-105":90},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},113768,1374391974468,"Eden","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0",7,"Healthcare","Lion’s Mane Neurological Activity (Hericium erinaceus) - Review of Traditional Use and Neuroprotective Potential","Hericium erinaceus, commonly known as lion’s mane, is an edible fungus with a long history in Traditional Chinese Medicine. The review highlights bioactive constituents, including β-glucan polysaccharides, hericenones, erinacine terpenoids, isoindolinones, sterols, and other myconutrients, and links them to potential neuroprotective and neuroregenerative effects. Anti-inflammatory activity, induction of nerve growth factor gene expression, and neurite outgrowth are emphasized for Alzheimer’s and Parkinson’s disease, supported by reports of good tolerability in two clinical studies.","Neurological Activity of Lion’s Mane (Hericium erinaceus)  \nKevin Spelman, PhD, MCPPa Elizabeth Sutherland, NDb Aravind Bagade, MDc  \n©2017, Kevin Spelman, PhD, MCPP Journal Compilation ©2017, AARM  \nDOI 10.14200/jrm.2017.6.0108  \nABSTRACT  \nHericium erinaceus, most commonly known as lion’s mane, is an edible fungus, with a long history of use in Traditional Chinese Medicine. The mushroom is abundant in bioactive compounds including β-glucan polysaccharides; hericenones and erinacineterpenoids; isoindolinones; sterols; and myconutrients, which potentially haveneuroprotective and neuroregenerative properties. Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium shows great promise for the treatment of Alzheimer’s and Parkinson’s diseases. The fungus was well tolerated in two clinical studies, with few adverse events reported.  \nKeywords: Lion’s mane; Neuroregeneration; Neurodegeneration; Neuroprotection; Neurotropins; Neurotrophic; Alzheimer’s disease; Parkinson’s disease; Multiple Sclerosis; Nerve growth factor  \naCorresponding author: Health, Education & Research, POB 599, Ashland, OR 97520, USA, Tel.: +1-541-708-3002; [E-mail: phytochemks@gmail.com](E-mail: phytochemks@gmail.com)  \nbAdjunct faculty National University of Natural Medicine, Portland, OR, USA  \nc Executive Secretary and Researcher, Ayurveda Interdisciplinary Research Minds Association, Mysore, India  \nJournal of Restorative Medicine 2017; 6: page 19  \nINTRODUCTION  \nAncient, traditional, and modern cultures around the world have known about the nutritive and medicinal properties of mushrooms for centuries. As early as 450 BCE, the Greek physician Hippocrates identified mushrooms as potent anti-inflammatory agents, useful for cauterizing wounds. In the East, reverence for fungi is evident in the Chinese description of ling zhi (Ganoderma lucidum), as the “spirit plant,” believed to provide longevity and spiritual potency.  \nModern medicine has been slower to catch on to the immense potential of fungi. Despite Fleming’s 1929 discovery of penicillin,1 and the subsequent implementation of the fungi-chemical as a blockbuster pharmaceutical in the 1940s,2 it is only in the last few decades that medical science has looked beyond the antimicrobial and cholesterollowering properties of fungi for other potential applications.  \nClinicians now have greater access to mycelium extracts, which are used clinically for their cytotoxic, antineoplastic, cardiovascular, antiinflammatory, and immune-modulating activities.3–5 Functional studies and chemical assays also support their potential to act as analgesic, antibacterial, antioxidant, and neuroprotective agents. A number of mushrooms, including Sarcodon scabrosus, Ganoderma lucidum, Grifolafrondosa, and Hericium erinaceus are reported to have activities related to nerve and brain health.6 Hericium erinaceus, a member of the Herinaceae family, is a culinary and medicinal mushroom. Both the mycelium and fruiting bodies of H. erinaceus have been shown to have therapeutic potential for brain and nerve health.7 The unique neurological activities of this fungus are the subject of this review.  \nTRADITIONAL USE OF LION’S  \nMANE (H. ERINACEUS)  \nHericium erinaceus (lion’s mane, yamabushitake, or bearded tooth carpophore) grows on old or dead broadleaf trees, and is used as both food and medicine in parts of Asia. The fruiting body  \nis called hóu tóu gū (“monkey head mushroom”) in Chinese8 and yamabushitake (“mountain monk mushroom”) in Japanese. In Chinese and Japanese medical systems, it has traditionally been used to fortify the spleen, nourish the gut, and also as an anticancer drug.9 Lion’s mane is said to be nutritive to the five internal organs (liver, lung, spleen, heart, and kidney), and promotes good digestion, general vigor, and strength. It is also recommended for gastric and duodenal ulcers, as well as chronic gast","cbCaig6cU8cd95E1","https://ap.wps.com/l/cbCaig6cU8cd95E1","pdf",370319,2,1,8,"English","en",105,"# Introduction\n## Traditional use of lion’s mane (Hericium erinaceus)\n## Chemistry\n### Polysaccharides\n## Polysaccharides: source and composition","[{\"question\":\"What is Hericium erinaceus (lion’s mane) used for traditionally?\",\"answer\":\"In Traditional Chinese and related medical systems, it has been used as food and medicine to support digestion and internal organ function, and for symptoms associated with Qi deficiency such as insomnia and weakness.\"},{\"question\":\"Which bioactive compounds in lion’s mane are emphasized for neurological activity?\",\"answer\":\"The text highlights β-glucan polysaccharides, hericenones and erinacine terpenoids, isoindolinones, sterols, and other myconutrients that may contribute to neuroprotective and neuroregenerative properties.\"},{\"question\":\"How does lion’s mane mycelium relate to neurotrophic mechanisms?\",\"answer\":\"Anti-inflammatory properties and promotion of nerve growth factor gene expression, along with neurite (axon or dendrite) outgrowth, are presented as key mechanisms supporting neuroprotective potential.\"}]",1784776886,20,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":28},"lions-mane-neurological-activity-hericium-erinaceus-review-of-traditional-use-and-neuroprotective-potential","",{"@graph":36,"@context":84},[37,53,67],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,47,50],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":20},"https://docshare.wps.com/document/","Document",{"item":48,"name":12,"@type":43,"position":49},"https://docshare.wps.com/document/healthcare/",3,{"item":51,"name":13,"@type":43,"position":52},"https://docshare.wps.com/document/lions-mane-neurological-activity-hericium-erinaceus-review-of-traditional-use-and-neuroprotective-potential/113768/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":24,"description":14,"dateModified":61,"datePublished":61,"encodingFormat":60,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":41,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-23",true,{"@type":64,"interactionType":65,"userInteractionCount":20},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"What is Hericium erinaceus (lion’s mane) used for traditionally?","Question",{"text":74,"@type":75},"In Traditional Chinese and related medical systems, it has been used as food and medicine to support digestion and internal organ function, and for symptoms associated with Qi deficiency such as insomnia and weakness.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"Which bioactive compounds in lion’s mane are emphasized for neurological activity?",{"text":79,"@type":75},"The text highlights β-glucan polysaccharides, hericenones and erinacine terpenoids, isoindolinones, sterols, and other myconutrients that may contribute to neuroprotective and neuroregenerative properties.",{"name":81,"@type":72,"acceptedAnswer":82},"How does lion’s mane mycelium relate to neurotrophic mechanisms?",{"text":83,"@type":75},"Anti-inflammatory properties and promotion of nerve growth factor gene expression, along with neurite (axon or dendrite) outgrowth, are presented as key mechanisms supporting 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