[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-113766-en":3,"doc-seo-113766-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},113766,1099514067438,"River Wang","https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542",7,"Healthcare","Lion’s Mane - Cognitive Vitality Report","Cognitive Vitality Reports compile neuroscientist-written evidence on agents that may influence brain health and age-related conditions, including drug targets, supplements, nutraceuticals, diet, and non-pharmacologic interventions. This report synthesizes available findings on Lion’s mane mushroom, covering potential cognitive effects, aging and related health considerations, and safety. Evidence includes a limited number of small clinical trials alongside broader preclinical and review literature, with clear emphasis on the need for larger, longer-duration, rigorously designed studies.","Cognitive Vitality Reports ® are reports written by neuroscientists at the Alzheimer’s Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-indevelopment, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm)for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data, from clinical trials if available, and from preclinical models.  \nLion’s Mane Mushroom  \nEvidence Summary  \nCognitive effects with lion’s mane supplementation have been mixed based on a few small pilot clinical trials. Larger, longer duration trials are needed to evaluate efficacy and safety.  \nNeuroprotective Benefit: Cognitive effects with lion’s mane have been mixed based on a few clinical trials; these trials had small numbers of participants and short durations of treatment. Well-designed larger and longer clinical trials are needed to evaluate efficacy.  \nAging and related health concerns: Preclinical studies suggest lion’s mane improves metabolic diseases and cancer. Studies in humans are very limited. One small study in humans suggests improved gut microbiome with lion’s mane supplementation.  \nSafety: Lion’s mane is generally recognized as safe when consumed as food. However, safety data are limited for long-term use of supplements. Long-term placebo-controlled and rigorously-designed clinical trials are needed to confirm safety of supplements.  \nWhat is it?  \nLion’s mane mushroom (also known as Hericium erinaceus and yamabushitake) is a medicinal, edible mushroom native to North America, Europe, and Asia. Lion’s mane mushrooms contain many bioactive compounds with potential health benefits, including polysaccharides (e.g., β-glucans), terpenoids, polyphenols, and peptides, which contribute to their immunomodulatory, antioxidant, antiinflammatory, and antimicrobial properties (reviewed in Contato et al., 2025 ) . Polysaccharides, especially β-glucans, have immunomodulatory, antimicrobial, and anti-tumor effects. Other polysaccharides (e.g., heteropolysaccharides composed of glucose, mannose, galactose, and arabinose) have demonstrated anti-oxidative and blood sugar-lowering effects. Lion’s mane mushrooms contain terpenoids called hericenones (derived from the fruiting body) and erinacines (derived from the mycelia), which have been shown to stimulate the synthesis of nerve growth factor (NGF), known to promote neuronal growth and repair. Erinacines are cyathin diterpenoids, of which 15 (A-K and P-S) have been identified to date in lion’s mane, with erinacine A being reported to have the greatest biological activity ( Li et al, 2018; Khan et al, 2013) . Lion’s mane mushrooms also contain ergothioneine (histidine derivative) and phenolic compounds that exhibit antioxidant effects (reviewed in Brandalise et al., 2023) .  \nMushrooms, in general, contain essential nutrients, including vitamin D, B vitamins, selenium, zinc, and potassium, as well as prebiotic fibers that support gut health. Lion’s mane is reported to haveneuroprotective, anti-cancer, and anti-inflammatory properties. However, there is no standardized treatment of lion’s mane. Some studies use powdered fruiting bodies or mycelia, while other studies use extracts from these different components. Similarly, lion’s mane products available in stores come indifferent forms.  \nNeuroprotective benefit: Cognitive effects with lion’s mane have been mixed based on a few clinical trials; these trials had small numbers of participants and short durations of treatment. Well-designed larger and longer clinical trials are needed to evaluate efficacy.  \nTypes of evidence:  \n• 7 randomized controlled trials  \n• Numerous laboratory studies  \n• Numerous review articles  \nHuman research to suggest prevention o","cbCaibQmYYbUXrt3","https://ap.wps.com/l/cbCaibQmYYbUXrt3","pdf",416166,2,1,13,"English","en",105,"# Evidence Summary\n## Cognitive effects with Lion’s mane\n## Neuroprotective benefit\n## Aging and related health concerns\n## Safety\n# What is Lion’s mane mushroom?\n## Bioactive compounds and potential mechanisms\n## Evidence types and human studies\n## Trial examples in mild cognitive impairment and healthy adults","[{\"question\":\"What does the evidence summary say about Lion’s mane and cognitive effects?\",\"answer\":\"Cognitive effects from Lion’s mane supplementation have been mixed across a few small pilot clinical trials. Larger, longer duration trials are needed to evaluate efficacy and safety.\"},{\"question\":\"What aging-related health concerns does the report discuss for Lion’s mane?\",\"answer\":\"Preclinical studies suggest Lion’s mane may improve metabolic diseases and cancer outcomes, while human evidence is very limited. One small human study suggests improvement in gut microbiome with supplementation.\"},{\"question\":\"How does the report assess the safety of Lion’s mane supplements?\",\"answer\":\"Lion’s mane is generally recognized as safe as a food. However, safety data for long-term supplement use are limited, and placebo-controlled long-term clinical trials are needed to confirm safety.\"}]",1784776865,33,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"lions-mane-cognitive-vitality-report","",{"@graph":36,"@context":85},[37,53,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,47,50],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":20},"https://docshare.wps.com/document/","Document",{"item":48,"name":12,"@type":43,"position":49},"https://docshare.wps.com/document/healthcare/",3,{"item":51,"name":13,"@type":43,"position":52},"https://docshare.wps.com/document/lions-mane-cognitive-vitality-report/113766/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":24,"description":14,"dateModified":61,"datePublished":62,"encodingFormat":60,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":41,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-25","2026-07-23",true,{"@type":65,"interactionType":66,"userInteractionCount":20},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What does the evidence summary say about Lion’s mane and cognitive effects?","Question",{"text":75,"@type":76},"Cognitive effects from Lion’s mane supplementation have been mixed across a few small pilot clinical trials. Larger, longer duration trials are needed to evaluate efficacy and safety.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"What aging-related health concerns does the report discuss for Lion’s mane?",{"text":80,"@type":76},"Preclinical studies suggest Lion’s mane may improve metabolic diseases and cancer outcomes, while human evidence is very limited. One small human study suggests improvement in gut microbiome with supplementation.",{"name":82,"@type":73,"acceptedAnswer":83},"How does the report assess the safety of Lion’s mane supplements?",{"text":84,"@type":76},"Lion’s mane is generally recognized as safe as a food. However, safety data for long-term supplement use are limited, and placebo-controlled long-term clinical trials are needed to confirm safety.","https://schema.org",{"og:url":51,"og:type":87,"og:title":13,"og:site_name":58,"og:description":14},"article",{"robots":89,"canonical":51},"index,follow",{"doc_id":7,"site_id":25},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,118,123,128,131,135],{"id":21,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":20,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":52,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":116,"slug":117},40,"healthcare",{"id":119,"doc_module":4,"doc_module_name":46,"category_name":120,"show_sort_weight":121,"slug":122},8,"Research & Report",30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":106,"slug":138},19,"General","general"]