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This prospective study enrolled 543 patients undergoing white light imaging, linked color imaging (LCI), and LCE sequentially to compare diagnostic performance for esophageal squamous cell cancer and precancerous lesions, including sensitivity, specificity, and lesion color characteristics. Results showed comparable sensitivity and higher specificity with LCI, plus shorter procedure time. LCI therefore supports a more suitable screening strategy for broader use.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/linked-color-imaging-vs-lugol-chromoendoscopy-for-esophageal-squamous-cell-cancer-and-precancerous-lesion-screening-a-noninferiority-study/379860/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/linked-color-imaging-vs-lugol-chromoendoscopy-for-esophageal-squamous-cell-cancer-and-precancerous-lesion-screening-a-noninferiority-study/379860.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is Lugol chromoendoscopy (LCE) limited for general population screening?","Question",{"text":112,"@type":113},"LCE is not suitable for general screening because it can induce esophageal spasms and chest pain and carries risks such as aspiration and iodine allergy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What was the main objective of the study comparing LCI and LCE?",{"text":117,"@type":113},"The study compared the diagnostic performance of linked color imaging (LCI) versus LCE for detecting esophageal squamous cell cancer and precancerous lesions, and assessed whether LCE could be replaced by LCI.",{"name":119,"@type":110,"acceptedAnswer":120},"What diagnostic performance results did the study find for LCI versus LCE?",{"text":121,"@type":113},"LCI showed similar sensitivity to LCE (83.7% vs 90.7%) but higher specificity (92.4% vs 87.0%), with LCI also having a significantly shorter procedure time.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379860,1790470168,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 March 28; 29(12): 1899-1910  \nDOI: 10.3748/wjg.v29.i12.1899 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nClinical Trials Study  \nLinked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: Anoninferiority study  \nZi-Xin Wang, Long-Song Li, Song Su, Jin-Ping Li, Bo Zhang, Nan-Jun Wang, Sheng-Zhen Liu, Sha-Sha Wang, Shuai Zhang, Ya-Wei Bi, Fei Gao, Qun Shao, Ning Xu, Bo-Zong Shao, Yi Yao, Fang Liu, En-Qiang Linghu, Ning-Li Chai  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B, B, B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Abe Y, Japan; Tyakht AV, United Kingdom; Woromogo SH, Congo  \nReceived: November 30, 2022  \nPeer-review started: November 30, 2022  \nFirst decision: December 20, 2022  \nRevised: December 29, 2022  \nAccepted: March 9, 2023  \nArticle in press: March 9, 2023  \nPublished online: March 28, 2023  \nZi-Xin Wang, Long-Song Li, Song Su, Jin-Ping Li, Bo Zhang, Nan-Jun Wang, Sheng-Zhen Liu, ShaSha Wang, Shuai Zhang, Ya-Wei Bi, Fei Gao, Qun Shao, Ning Xu, Bo-Zong Shao, Yi Yao, Fang Liu, En-Qiang Linghu, Ning-Li Chai, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China  \nCorresponding author: Ning-Li Chai, MD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, [China.](China. csxlily@163.com)[ csxlily@163.com](China. csxlily@163.com)  \nAbstract  \nBACKGROUND  \nLugol chromoendoscopy (LCE) has served as a standard screening technique in high-risk patients with esophageal cancer. Nevertheless, LCE is not suitable for general population screening given its side effects. Linked color imaging (LCI) is a novel image-enhanced endoscopic technique that can distinguish subtle differences in mucosal color.  \nAIM  \nTo compare the diagnostic performance of LCI with LCE in detecting esophageal squamous cell cancer and precancerous lesions and to evaluate whether LCE can be replaced by LCI in detecting esophageal neoplastic lesions.  \nMETHODS  \nIn this prospective study, we enrolled 543 patients who underwent white light imaging (WLI), LCI and LCE successively. We compared the sensitivity and specificity of LCI and LCE in the detection of esophageal neoplastic lesions. Clinicopathological features and color analysis of lesions were assessed.  \nRESULTS  \nIn total, 43 patients (45 neoplastic lesions) were analyzed. Among them, 36 patients (38 neoplastic lesions) were diagnosed with LCI, and 39 patients (41 neoplastic lesions) were diagnosed with LCE. The sensitivity of LCI was similar to that of LCE (83.7% vs 90.7%, P = 0.520), whereas the specificity of LCI was greater  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1899 March 28, 2023  Volume 29  Issue 12   \nWang ZX et al. LCI and LCE screening esophageal cancer  \nthan that of LCE (92.4% vs 87.0%, P = 0.007) . The LCI procedure time in the esophageal examination was significantly shorter than that of LCE [42 (34, 50) s vs 160 (130, 189) s, P \u003C 0.001] . The color difference between the lesion and surrounding mucosa in LCI was significantly greater than that observed with WLI. However, the color difference in LCI was similar in different pathological types of esophageal squamous cell cancer.  \nCONCLUSION  \nLCI offers greater specificity than LCE in the detection of esophageal squamous cell cancer and precancerous lesions, and LCI represents a promising screening strategy for general population","cbCaip8IC2dfltRG","https://ap.wps.com/l/cbCaip8IC2dfltRG","pdf",3726649,13,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip","[{\"question\":\"Why is Lugol chromoendoscopy (LCE) limited for general population screening?\",\"answer\":\"LCE is not suitable for general screening because it can induce esophageal spasms and chest pain and carries risks such as aspiration and iodine allergy.\"},{\"question\":\"What was the main objective of the study comparing LCI and LCE?\",\"answer\":\"The study compared the diagnostic performance of linked color imaging (LCI) versus LCE for detecting esophageal squamous cell cancer and precancerous lesions, and assessed whether LCE could be replaced by LCI.\"},{\"question\":\"What diagnostic performance results did the study find for LCI versus LCE?\",\"answer\":\"LCI showed similar sensitivity to LCE (83.7% vs 90.7%) but higher specificity (92.4% vs 87.0%), with LCI also having a significantly shorter procedure time.\"}]","Linked color imaging vs Lugol chromoendoscopy for esophageal squamous cell cancer and precancerous lesion screening: A noninferiority study | PDF",1790237787,33]