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While long non-coding RNAs (lncRNAs) are recognized regulators of CRC progression, their functional coordination with metabolic programs is not well defined. The study identifies LINC02878 as an oncogenic lncRNA upregulated in CRC and linked to poor prognosis. Mechanistically, LINC02878 binds ZNF282 to drive PYCR2 expression, boosting proline biosynthesis and tumor aggressiveness, and LINC02878 knockdown inhibits growth and lung metastasis in xenografts.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/linc02878znf282pycr2-axis-promotes-proline-synthesis-and-tumor-progression-in-colorectal-cancer/455626/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/linc02878znf282pycr2-axis-promotes-proline-synthesis-and-tumor-progression-in-colorectal-cancer/455626.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does LINC02878 play in colorectal cancer progression?","Question",{"text":112,"@type":113},"LINC02878 is identified as an oncogenic lncRNA that is significantly upregulated in colorectal cancer and correlates with poor prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does LINC02878 regulate PYCR2 and proline biosynthesis?",{"text":117,"@type":113},"LINC02878 binds to ZNF282 to activate PYCR2 expression, which enhances proline biosynthesis and promotes tumor aggressiveness.",{"name":119,"@type":110,"acceptedAnswer":120},"What effects does LINC02878 knockdown have in vivo?",{"text":121,"@type":113},"LINC02878 knockdown suppresses subcutaneous tumor growth, reduces lung metastasis, and improves survival in xenograft models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455626,1791344840,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Cellular and Molecular Life Sciences (2026) 83:25  \n[https://doi.org/10.1007/s00018-025-05968-3](https://doi.org/10.1007/s00018-025-05968-3) Cellular and Molecular Life Sciences  \nORIGINAL ARTICLE  \nLINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer  \nJun-ping Lei1 · Lin Wang2 · Tian-yang Wang1 · Bing-hu Lin1 · Yan Xu1 · Song Shang1 · Tian Xia1 · Min-ming Gong1 · Yu Guo1 · Jia Fu3 · Yuan-lin Li4  \nReceived: 21 June 2025 / Revised: 29 September 2025 / Accepted: 23 October 2025 © The Author(s) 2025  \nAbstract  \nColorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with poor survival outcomes in advanced stages due to therapy resistance and metastasis. While long non-coding RNAs (lncRNAs) are emerging as key regulators of CRC progression, their functional interplay and metabolic implications remain poorly understood. Here, we identified LINC02878 as a novel oncogenic lncRNA significantly upregulated in CRC and correlated with poor prognosis. Mechanistically, LINC02878 binds to the ZNF282 to activate PYCR2 expression, thereby enhancing proline biosynthesis and driving tumor aggressiveness. In vivo, LINC02878 knockdown suppressed subcutaneous tumor growth, reduced lung metastasis, and improved survival in xenograft models. Our study unveils the LINC02878/ZNF282/PYCR2/proline axis as a critical metabolic vulnerability in CRC, offering potential therapeutic targets for intervention.  \nKeywords LINC02878 · ZNF282 · PYCR2 · Proline synthesis · Colorectal cancer  \nJun-ping Lei, Lin Wang, Tian-yang Wang, Yu Guo, Jia Fu and Yuanlin Li contributed equally to this work.  \n􀀍 Yu Guo [G_Yu1982032@126.com](G_Yu1982032@126.com)  \n􀀍 Jia Fu [JiaFu_xyyy@yeah.net](JiaFu_xyyy@yeah.net)  \n􀀍 Yuan-lin Li [Yuanlin_Li@yeah.net](Yuanlin_Li@yeah.net)  \n1 Department of Colorectal and Anal Surgery, Hubei University of Medicine, Xiangyang No.1 People’s Hospital, Xiangyang 441000, China  \n2 Department of Gastroenterology, People’s Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang 441000, China  \n3 Department of Pulmonary and Critical Care Medicine, People’s Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang 441000, China  \n4 Department of Medical Insurance Price Management Office, People’s Hospital, Hubei University of Medicine, Xiangyang No.1, Xiangyang 441000, China  \nAbbreviations  \nALKBH5  \nALMS1-IT1  \nErα  \nHMGCS2  \nIGF2BP1  \nmCRC  \nSIRT3  \nSLC7A11  \nSP100-AS1  \nTAF15  \nTPD52  \nVKORC1L1  \nZIC2 ZNF282  \nCCNA1  \nCDC6  \nCOADREAD  \nCoCoA  \nCRC DEGs  \nAlkB homolog 5, RNA demethylase ALMS1 intronic transcript 1  \nEstrogen receptor α 3-hydroxy-3-methylglutaryl-CoA synthase 2  \nInsulin like growth factor 2 mRNA binding protein 1  \nMetastatic CRC Sirtuin 3  \nSolute carrier family 7 member 11 lncRNA targeting antisense sequence of SP100 gene  \nTBP-associated factor 15  \nTumor protein D52  \nVitamin K epoxide reductase complex subunit 1L1  \nZic family zinc finger 2  \nZinc finger protein 282  \nCyclin A1  \nCell division cycle 6  \nColorectal adenocarcinoma Coiled-coil coactivator Colorectal cancer Differentially expressed genes  \n1 3  \nE2F1  \nESCC  \nGO  \nGSEA  \nH&E  \nHK2  \nHPA  \nIHC  \nKEGG  \nKLF7  \nlncRNAs  \nLOXL1-AS1  \nMZF1-AS1  \nOS  \nPARP1  \nPFI  \nPYCR1  \nPYCR2  \nRIP  \nRNA-FISH  \nRNF14 ROC RT-qPCR  \nSNHG4  \nSOX2  \nSTAT3  \nTCGA  \nTFs  \nZNF282  \nE2F transcription factor 1  \nEsophageal squamous cell carcinoma Gene Ontolog  \nGene set enrichment analysis Hematoxylin& eosin Hexokinase 2  \nHuman Protein Atlas Immunohistochemistry  \nKyoto Encyclopedia of Genes and Genomes  \nKLF transcription factor 7  \nLong non-coding RNAs LOXL1 antisense RNA 1  \nMZF1 antisense RNA 1  \nOverall survival  \nPoly (ADP-ribose) polymerase 1  \nProgression-free interval  \nPyrroline-5-carboxylate reductase 1  \nPyrroline-5-carboxylate reductase 2 RNA Immunoprecipitation  \nRNA fluorescence in situ hybridization Ring finger protein 14  \nReceiver operating characteristic Reverse transcription-quant","cbCaidGYXtv7gNiu","https://ap.wps.com/l/cbCaidGYXtv7gNiu","pdf",18147971,"English","# Introduction\n# Abstract\n# Keywords","[{\"question\":\"What role does LINC02878 play in colorectal cancer progression?\",\"answer\":\"LINC02878 is identified as an oncogenic lncRNA that is significantly upregulated in colorectal cancer and correlates with poor prognosis.\"},{\"question\":\"How does LINC02878 regulate PYCR2 and proline biosynthesis?\",\"answer\":\"LINC02878 binds to ZNF282 to activate PYCR2 expression, which enhances proline biosynthesis and promotes tumor aggressiveness.\"},{\"question\":\"What effects does LINC02878 knockdown have in vivo?\",\"answer\":\"LINC02878 knockdown suppresses subcutaneous tumor growth, reduces lung metastasis, and improves survival in xenograft models.\"}]","LINC02878/ZNF282/PYCR2 axis promotes proline synthesis and tumor progression in colorectal cancer | PDF",1790743662,48]