[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336346-105":59,"doc-detail-336346-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","linc01503-in-cancer-from-molecular-mechanisms-to-therapeutic-implications","LINC01503 in cancer: from molecular mechanisms to therapeutic implications","","Long non-coding RNAs (lncRNAs) regulate tumor growth and metastasis across many cancer types, and Linc01503 is presented as a key lncRNA located on human chromosome 19. Evidence links linc01503 dysregulation to malignant phenotypes and to advanced clinicopathological characteristics, correlating with poor prognosis. The work outlines molecular pathways controlled by linc01503 and highlights its clinical relevance, proposing its value as a biomarker and therapeutic target, with future perspectives for precision molecular medicine in carcinogenesis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/linc01503-in-cancer-from-molecular-mechanisms-to-therapeutic-implications/336346/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/linc01503-in-cancer-from-molecular-mechanisms-to-therapeutic-implications/336346.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is Linc01503 and where is it located?","Question",{"text":112,"@type":113},"Linc01503 is a long non-coding RNA located on human chromosome 19.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is linc01503 linked to cancer progression and outcomes?",{"text":117,"@type":113},"Dysregulation of linc01503 is associated with malignant behaviors, advanced clinicopathological factors, and an unfavorable prognosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review aim to cover about linc01503?",{"text":121,"@type":113},"It summarizes the molecular pathways governed by linc01503 and its clinical relevance, including future prospects for clinical application.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336346,1790129902,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Clinical and Experimental Medicine (2024) 24:120 [https://doi.org/10.1007/s10238-024-01383-3](https://doi.org/10.1007/s10238-024-01383-3)  \nLINC01503 in cancer: from molecular mechanisms to therapeutic implications  \nYou Shuai1 · Haili Qian2 · Peng Yuan3  \nReceived: 7 May 2024 / Accepted: 21 May 2024 / Published online: 7 June 2024 © The Author(s) 2024  \nAbstract  \nLong non-coding RNAs (lncRNAs) are fundamental agents that govern tumor growth and metastasis across a spectrum of cancer types. Linc01503 is a novel lncRNA situated on human chromosome 19, and it is intricately linked with the pathogenesis of multiple human cancers, underscoring its substantial role and significance in cancer development. It has been recognized as a pivotal contributor to inducing malignant behaviors in lung cancer, gastric cancer, colorectal cancer, cholangiocarcinoma, liver cancer and pancreatic cancer, among others. The dysregulation of linc01503 has been shown to strongly associate with advanced clinicopathological factors and foretell an unfavorable prognosis, indicating its prospective clinical significance as a valuable biomarker and therapeutic target for individuals with cancer. The primary objective of the current work is to present the intricate molecular pathways governed by linc01503 and its profound clinical relevance in the context of carcinogenesis. We also focus on the future prospects of linc01503-based clinical application. This will help us to better understand the regulatory mechanism of carcinogenesis and provide new ideas for precision molecular medicine.  \nKeywords Linc01503 · Cancer · Mechanism · Clinical application  \nIntroduction  \nCancer is a major public health problem worldwide [1] . It is a complex pathological event that can be initiated by a multitude of driving forces and influences, encompassing gene dysregulation, epigenetic modifications, environmental factors, etc. [2] . Delays in the diagnosis and treatment  \n* Haili Qian [qianhaili001@163.com](qianhaili001@163.com)  \n* Peng Yuan [yuanpengyp01@163.com](yuanpengyp01@163.com)  \n1 Department of Medical Oncology, National Cancer Centre/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \n2 State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \n3 Department of VIP Medical Services, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \nmay culminate in an escalation of advanced-stage disease and higher mortality rates, which calls for identification of novel biomarkers [2] . Therefore, it is imperative to elucidate the mechanistic networks underlying tumorigenesis and progression to enhance cancer diagnosis and treatment. The recent identification of genetic alterations and dysregulation of critical factors involved in carcinogenesis offers new opportunities for precision molecular medicine, with long  \nnon-coding RNAs (lncRNAs) as promising biomarkers. LncRNAs, consisting of more than 200 nucleotides, govern gene expression and contribute to various biological processes through a range of pathways and molecular mechanisms [3] . Recent research indicates that lncRNAshave significant implications in various cancer types. Their involvements encompass sequestering microRNAs, engaging with RNA-binding proteins, modulating gene transcription, influencing alternative splicing, and affecting protein translation [4, 5] . Linc01503 is a novel lncRNA located inhuman chromosome 19 and closely correlated with human cancer development, including lung cancer, gastric cancer, colorectal cancer, cholangiocarcinoma, liver cancer, etc.[6–10](Fig. 1) . For instance, it was initially identified t","cbCaimI3BxXsOuLH","https://ap.wps.com/l/cbCaimI3BxXsOuLH","pdf",1719278,"English","# Abstract\n# Introduction\n# The underlying mechanism and clinical potentials of linc01503 in malignant diseases\n## Gastric cancer","[{\"question\":\"What is Linc01503 and where is it located?\",\"answer\":\"Linc01503 is a long non-coding RNA located on human chromosome 19.\"},{\"question\":\"How is linc01503 linked to cancer progression and outcomes?\",\"answer\":\"Dysregulation of linc01503 is associated with malignant behaviors, advanced clinicopathological factors, and an unfavorable prognosis.\"},{\"question\":\"What does the review aim to cover about linc01503?\",\"answer\":\"It summarizes the molecular pathways governed by linc01503 and its clinical relevance, including future prospects for clinical application.\"}]","LINC01503 in cancer: from molecular mechanisms to therapeutic implications | PDF",1790014650,25]