[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332510-105":59,"doc-detail-332510-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","linc01089-in-cancer-multifunctional-roles-and-therapeutic-implications","LINC01089 in cancer - multifunctional roles and therapeutic implications","","LINC01089 is a long non-coding RNA that is strongly implicated in the progression of human cancers. Located on 12q24.31, it has been shown to exert tumor-suppressive effects across multiple cancer types, while reports in hepatocellular carcinoma differ among studies. This review synthesizes evidence from bioinformatics, clinical cohorts, animal models, and fundamental experiments to clarify mechanisms. It also evaluates LINC01089 as a prospective biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/linc01089-in-cancer-multifunctional-roles-and-therapeutic-implications/332510/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/linc01089-in-cancer-multifunctional-roles-and-therapeutic-implications/332510.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What type of RNA is LINC01089 and where is it located?","Question",{"text":112,"@type":113},"LINC01089 is a long non-coding RNA. 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Journal of Translational Medicine (2024) 22:858  \n[https://doi.org/10.1186/s12967-024-05693-8](https://doi.org/10.1186/s12967-024-05693-8)  \nJournal of Translational Medicine  \n REVIEW Open Access  \nLINC01089 in cancer: multifunctional roles   and therapeutic implications  \nQiang Yi1†, Gangfeng Zhu1†, Xinting Ouyang1†, Weijian Zhu1, Kui Zhong1, Zheng Chen1 and Jinghua Zhong2*  \nAbstract  \nLINC01089 is a prime example of a long non-coding RNA that plays a pivotal role in the progression of human cancers. The gene encoding this lncRNA is located on 12q24 .31. LINC01089 has been demonstrated to exert tumorsuppressive effects in various cancers, including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, cervical cancer, papillary thyroid carcinoma, breast cancer, and osteosarcoma. However, its role in hepatocellular carcinoma shows significant discrepancies across different studies. In this review, we systematically explore the functions of LINC01089 in human cancers through bioinformatics analysis, clinical studies, animal models, and fundamental experimental research. Furthermore, we delve into the biological mechanisms and functions of LINC01089, and discuss its potential as a future biomarker and therapeutic target in detail.  \nKeywords LncRNA, LINC01089, Malignant cancers, Biological, Clinical therapies  \nIntroduction  \nCancer represents a major public health challenge globally, with nearly 10 million deaths annually attributed to the disease [1, 2]. The intricate pathophysiology of cancer arises from a multitude of factors, including genetic dysregulation, epigenetic modifications, and environmental influences [3–5]. Due to individual variations, tumor heterogeneity, and inherent limitations of current treatments, prognosis remains poor for the majority of patients [6]. Consequently, the identification of novel therapeutic targets is imperative. Understanding the intricate networks underpinning tumorigenesis and cancer progression is crucial for advancing cancer diagnosis and therapy. Recent research has unveiled key genetic  \n†Qiang Yi, Gangfeng Zhu and Xinting Ouyang contributed equally to this work.  \n*Correspondence: Jinghua Zhong [m18770738786@163.com](m18770738786@163.com)  \n1 The First Clinical Medical College, Gannan Medical University, Ganzhou 341000, Jiangxi, China  \n2 Department of Oncology, The First Affiliated Hospital of Gannan Medical University, 128 Jinling Road, Ganzhou 341000, Jiangxi, China  \nalterations and dysregulations associated with oncogenesis, paving the way for precision molecular medicine. Long non-coding RNAs (lncRNAs) have emerged as promising biomarkers with significant potential applications.  \nLong non-coding RNAs are transcripts exceeding 200 nucleotides in length that lack an open reading frame for protein coding [7]. Typically transcribed by RNA polymerase II, they undergo splicing and polyadenylation and regulate gene expression through various pathways and molecular mechanisms, participating in diverse biological processes [8]. Acting as “RNA sponges” or competing endogenous RNAs (ceRNAs), they modulate tumor-related biological processes, including cell proliferation, metastasis, and drug resistance [9]. Their roles encompass sequestering microRNAs, binding to RNAbinding proteins, regulating gene transcription, influencing alternative splicing, and affecting protein translation [10]. Dysregulation of lncRNAs is linked to numerous diseases, such as cardiovascular diseases [11], neurodegenerative diseases [12], metabolic disorders [13], autoimmune diseases [14], infectious diseases [15] and inflammatory conditions [16]. By impacting gene expression and cellular processes, lncRNAs contribute to both  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the orig","cbCailNCFTyYJw9Z","https://ap.wps.com/l/cbCailNCFTyYJw9Z","pdf",2743064,15,"English","# Abstract\n# Keywords\n# Introduction\n## Long non-coding RNAs in cancer biology\n## LINC01089 identity and genomic context\n## Prior evidence across cancer types","[{\"question\":\"What type of RNA is LINC01089 and where is it located?\",\"answer\":\"LINC01089 is a long non-coding RNA. The gene encoding it is located on 12q24.31.\"},{\"question\":\"How does LINC01089 affect cancers in general, and what is different about hepatocellular carcinoma?\",\"answer\":\"Across several cancers, LINC01089 has demonstrated tumor-suppressive effects. Its role in hepatocellular carcinoma shows significant discrepancies across studies.\"},{\"question\":\"How is LINC01089 studied in this review?\",\"answer\":\"The review explores LINC01089 functions using bioinformatics analysis, clinical studies, animal models, and fundamental experimental research.\"}]","LINC01089 in cancer - multifunctional roles and therapeutic implications | PDF",1789998552,38]