[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427425-105":59,"doc-detail-427425-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","life-course-stressors-and-cognitive-function-a-latent-profile-analysis-approach","Life Course Stressors and Cognitive Function - A Latent Profile Analysis Approach","","Psychosocial stressors are established risk factors for cognitive decline, yet prior studies often examine single stressor domains or isolated life stages, missing how multiple exposures accumulate across the life course. Using the Midlife in the United States study (n=3,684; age 32–84), latent profile analysis characterized stressor patterns across 11 domains and related profile membership to cognitive outcomes via generalized estimating equations. Results showed profile-specific associations and notable differences by race/ethnicity, indicating cognitive health may be differentially predicted by distinct life course stressor constellations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/life-course-stressors-and-cognitive-function-a-latent-profile-analysis-approach/427425/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/life-course-stressors-and-cognitive-function-a-latent-profile-analysis-approach/427425.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-12","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of the study?","Question",{"text":112,"@type":113},"To identify life course stressor profiles and examine how these profiles are associated with cognitive function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were stressor profiles determined in the study?",{"text":117,"@type":113},"Latent profile analysis identified three profiles based on 11 psychosocial stressor domains.",{"name":119,"@type":110,"acceptedAnswer":120},"Did the associations between stressor profiles and cognition differ by race or ethnicity?",{"text":121,"@type":113},"Yes. The study found that associations, including those involving executive function and episodic memory, varied across non-Hispanic Blacks, non-Hispanic Whites, and Hispanics.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427425,1790789815,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","754 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.2565  \nLIFE COURSE STRESSORS AND COGNITIVE  \nFUNCTION: A LATENT PROFILE ANALYSIS  \nAPPROACH  \nJean Choi1, and Elizabeth Muñoz2, 1. The University of Texas at Austin, Texas, United States, 2. University of Texas at Austin, Austin, Texas, United States  \nPsychosocial stressors are risk factors for poor cognitive health, but existing research has largely focused on testing associations between single stressor domains or on specific life stages, overlooking the combined role of stressors across the life course. Moreover, marginalized racial/ethnic groups may be more susceptible to the effects of some exposures compared to their counterparts. We aimed to identify life course stressor profiles and examine  \nInnovation in Aging, 2025, Vol. 9, No. S2 755  \ntheir associations with cognitive function using the Midlife in the United States study (n=3,684; age: 32–84). Latent profile analysis identified three profiles of life course stressors based on 11 domains: High Everyday Discrimination, High Work Stress, and High Multi-Domain Stress. Generalized estimating equations tested associations between profile membership and cognitive function. Compared to the High Everyday Discrimination profile, the High Work Stress profile had better executive function (b=0.07, SE =0.04, p = .016). Among non-Hispanic Blacks, the positive association between High Work Stress and executive function was weaker than for non-Hispanic Whites (b = -0.41, SE = 0.17, p = .01) . The High Multi-Domain Stress profile had higher executive function among Hispanics (b =0.64, SE=0.26, p = .013) and greater episodic memory for both non-Hispanic Black (b=0.44, SE=0.21, p = .01) and Hispanics (b =0.61, SE=0.30, p = .04) compared to non-Hispanic Whites. These results suggest that cognitive health outcomes may be differentially predicted by distinct patterns of life course stressors, and its associations may vary by race/ethnicity.","cbCaidT4LmvaFXAQ","https://ap.wps.com/l/cbCaidT4LmvaFXAQ","pdf",1310998,"English","# Abstract\n## Study aim and design\n## Stressor profiles and analysis method\n## Cognitive function associations\n## Race/ethnicity moderation and implications","[{\"question\":\"What is the main goal of the study?\",\"answer\":\"To identify life course stressor profiles and examine how these profiles are associated with cognitive function.\"},{\"question\":\"How were stressor profiles determined in the study?\",\"answer\":\"Latent profile analysis identified three profiles based on 11 psychosocial stressor domains.\"},{\"question\":\"Did the associations between stressor profiles and cognition differ by race or ethnicity?\",\"answer\":\"Yes. The study found that associations, including those involving executive function and episodic memory, varied across non-Hispanic Blacks, non-Hispanic Whites, and Hispanics.\"}]","Life Course Stressors and Cognitive Function - A Latent Profile Analysis Approach | PDF",1790643819]