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The Korean Society of Critical Care Medicine provides clinical practice guideline recommendations for ventilator liberation, integrating evidence-based approaches. Meta-analyses and comprehensive syntheses were assessed using the GRADE framework, with outcomes presented as evidence profiles. Recommendations address nine PICO questions, including conditional and expert-consensus 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pISSN 2586-6052 | eISSN 2586-6060  \nLiberation from mechanical ventilation in critically ill patients: Korean Society of Critical Care Medicine Clinical Practice Guidelines  \nTae Sun Ha1, Dong Kyu Oh2, Hak-Jae Lee3, Youjin Chang4, In Seok Jeong5, Yun Su Sim6,7, Suk-Kyung Hong3, Sunghoon Park7,8, Gee Young Suh9,10, So Young Park7,11  \n1Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea 2Department of Pulmonology, Dongkang Medical Center, Ulsan, Korea  \n3Division ofAcute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea  \n4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea  \n5Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital, Gwangju, Korea  \n6Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea 7Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea  \n8Department of Pulmonary, Allergy, and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea  \n9Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea  \n10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 11Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea  \nBackground: Successful liberation from mechanical ventilation is one of the most crucial processes in critical care because it is the first step by which a respiratory failure patient begins to transition out of the intensive care unit and return to their own life. Therefore, when devising appropriate strategies for removing mechanical ventilation, it is essential to consider not only the individual experiences of healthcare professionals, but also scientific and systematic approaches. Recently, numerous studies have investigated methods and tools for identifying when mechanically ventilated patients are ready to breathe on their own. The Korean Society of Critical Care Medicine therefore provides these recommendations to clinicians about liberation from the ventilator.  \nMethods: Meta-analyses and comprehensive syntheses were used to thoroughly review, compile, and summarize the complete body of relevant evidence. All studies were meticulously assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method, and the outcomes were presented succinctly as evidence profiles. Those evidence syntheses were discussed by a multidisciplinary committee of experts in mechanical ventilation, who then developed and approved recommendations.  \nResults: Recommendations for nine PICO (population, intervention, comparator, and outcome) questions about ventilator liberation are presented in this document. This guideline includes seven conditional recommendations, one expert consensus recommendation, and one conditional deferred recommendation.  \nConclusions: We developed these clinical guidelines for mechanical ventilation liberation to provide meaningful recommendations. These guidelines reflect the best treatment for patients seeking liberation from mechanical ventilation.  \nKey Words: critical illness; guidelines; mechanical ventilation; ventilator weaning  \nGuideline  \nReceived: January 23, 2024  \nAccepted: February 14, 2024  \nCorresponding author  \nSo Young Park  \nDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine","cbCaiqNK70GXTxYR","https://ap.wps.com/l/cbCaiqNK70GXTxYR","pdf",32324320,224,"English","# Summary of Recommendations\n## Question 1\n## Question 2-1\n## Question 2-2\n## Question 3","[{\"question\":\"What is the main purpose of these clinical practice guidelines?\",\"answer\":\"To provide evidence-based recommendations for liberation from mechanical ventilation in critically ill patients.\"},{\"question\":\"How were the recommendations developed?\",\"answer\":\"Relevant evidence was reviewed using meta-analyses and comprehensive syntheses, with studies assessed using the GRADE method and outcomes organized as evidence profiles by a multidisciplinary expert committee.\"},{\"question\":\"What types of recommendations are included for ventilator liberation?\",\"answer\":\"The guideline presents recommendations for nine PICO questions, including seven conditional recommendations, one expert consensus recommendation, and one conditional deferred recommendation.\"}]","Liberation from mechanical ventilation in critically ill patients - Korean Society of Critical Care Medicine Clinical Practice Guidelines | PDF",1791161335,564]