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The review summarizes mechanistic and clinical evidence for recent years and highlights ongoing gaps in explaining LNT signaling pathways in inflammation and cancer.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/lentinan-progress-in-inflammatory-diseases-and-tumor-diseases/338778/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/lentinan-progress-in-inflammatory-diseases-and-tumor-diseases/338778.png","ImageObject",300,407,{"name":42,"@type":43},"Jiven","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is lentinan (LNT) and what main biological effects does it have?","Question",{"text":63,"@type":64},"Lentinan is an active substance extracted from shiitake mushrooms. It is described as having antioxidant, anti-inflammatory, and anti-tumor functions, along with other biological activities.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is LNT used in cancer treatment according to the review?",{"text":68,"@type":64},"LNT has been approved as an adjunct to chemotherapy in China and Japan. Studies indicate improved patient prognosis and immune function, with reduced chemotherapy side effects in cancers such as lung, colorectal, and gastric cancer.",{"name":70,"@type":61,"acceptedAnswer":71},"Why are effective treatments for inflammatory diseases and cancer still needed?",{"text":72,"@type":64},"Inflammatory diseases and cancers are leading causes of death worldwide, and the review states there remains a lack of effective treatments. 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European Journal  \nEuropean Journal of Medical Research (2024) 29:8  \n[https://doi.org/10.1186/s40001-023-01585-7](https://doi.org/10.1186/s40001-023-01585-7 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-023-01585-7 of Medical Research)  \n REVIEW Open Access  \nLentinan progress in inflammatory diseases and tumor diseases  \nGuangda Zhou1, Haiyan Liu2, Ying Yuan3, Qian Wang4*, Lanping Wang5* and Jianghua Wu6*  \nAbstract  \nShiitake mushrooms are a fungal food that has been recorded in Chinese medicine to nourish the blood and qi. Lentinan (lLNT) is an active substance extracted from shiitake mushrooms with powerful antioxidant, anti-inflammatory, anti-tumor functions. Inflammatory diseases and cancers are the leading causes of death worldwide, posing a serious threat to human life and health and posing enormous challenges to global health systems. There is still a lack of effective treatments for inflammatory diseases and cancer. LNT has been approved as an adjunct to chemotherapy in China and Japan. Studies have shown that LNT plays an important role in the treatment of inflammatory diseases as well as oncological diseases. Moreover, clinical experiments have confirmed that LNT combined with chemotherapy drugs has a significant effect in improving the prognosis of patients, enhancing their immune function and reducing the side effects of chemotherapy in lung cancer, colorectal cancer and gastric cancer. However, the relevant mechanism of action ofthe LNT signaling pathway in inflammatory diseases and cancer. Therefore, this article reviews the mechanism and clinical research of LNT in inflammatory diseases and tumor diseases in recent years. Keywords Lentinan, Inflammatory diseases, Tumor, Cancer  \nIntroduction  \nShiitake mushrooms are nutrient-rich, widely cultivated fungal plants, and their active extracts are also widely used as traditional Chinese medicine in the treatment of  \n*Correspondence:  \nQian Wang [qianqianwangxi@163.com](qianqianwangxi@163.com)[ ](qianqianwangxi@163.com)Lanping Wang [fywanglanping123@126.com](fywanglanping123@126.com)[ ](fywanglanping123@126.com)Jianghua Wu[lcwjh1978@163.com](lcwjh1978@163.com)  \n1 Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Jinan 250062, China  \n2 Department of Ultrasound, The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, China  \n3 Department of Neurology, Xingtai Third Hospital, Xingtai 054000, China  \n4 Department of Central Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, China  \n5 Department of Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China  \n6 School of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China  \nvarious diseases [1]. A large number of pharmacological and clinical studies have shown that lentinan (LNT) that one of the active shiitake mushroom extracts, has antioxidant, immunomodulatory, anti-tumor, anti-cancer, hypoglycemic, hypolipidemic and other biological activities [2–5]. LNT are macromolecules with a β-1,3-D-glucan and its unique molecular structure is closely related to its pharmacological activity, and the glucan of the β-glycosidic bond is the key structure for its antitumor function [6, 7]. LNT has been approved as anadjuvant therapy for cancer in Japan and China [3, 8]. However,the in vivo pharmacokinetics of LNT and the molecular mechanism of anti-inflammatory and anticancer have not been explained [9].  \nInflammatory diseases can be defined as a general term for a large group of diseases, including inflammation in various systems [10] . The severity of which has different effects on people. Light cases can heal themselves, and severe cases can endanger life, such as COVID-19, which has major damage to the global health system [11] . Malignant tumors pose a serious  \n© The Author(s) 2023. Open Access This ","cbCairShkRFyfD2q","https://ap.wps.com/l/cbCairShkRFyfD2q","pdf",1202905,12,"English","# Abstract\n# Introduction\n## Active components of shiitake and biological activities of LNT\n## Link between inflammation and tumors\n## Clinical use and therapeutic potential","[{\"question\":\"What is lentinan (LNT) and what main biological effects does it have?\",\"answer\":\"Lentinan is an active substance extracted from shiitake mushrooms. It is described as having antioxidant, anti-inflammatory, and anti-tumor functions, along with other biological activities.\"},{\"question\":\"How is LNT used in cancer treatment according to the review?\",\"answer\":\"LNT has been approved as an adjunct to chemotherapy in China and Japan. Studies indicate improved patient prognosis and immune function, with reduced chemotherapy side effects in cancers such as lung, colorectal, and gastric cancer.\"},{\"question\":\"Why are effective treatments for inflammatory diseases and cancer still needed?\",\"answer\":\"Inflammatory diseases and cancers are leading causes of death worldwide, and the review states there remains a lack of effective treatments. It also notes the mechanisms, especially involving LNT signaling pathways, are not fully explained.\"}]","Lentinan progress in inflammatory diseases and tumor diseases | PDF",1790025600]