[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378552-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-378552-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","leading-the-pack-best-practices-in-comparative-canine-cancer-genomics-to-inform-human-oncology","Leading the pack - Best practices in comparative canine cancer genomics to inform human oncology","","Pet dogs develop spontaneous cancers at an estimated rate five times higher than that of humans, making them a valuable model for studying cancer biology and assessing new therapeutic strategies within an intact-immune, human-relevant setting. While interest has persisted for decades, progress was constrained by limited cellular and molecular reagents and by gaps in understanding the genomic architecture of canine tumors. Recent advances—reference genome resources, multi-omic analysis tools, and the Integrated Canine Data Commons—enable deeper translational integration. This review summarizes these developments and points to available resources to support comparative research and improve human outcomes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/leading-the-pack-best-practices-in-comparative-canine-cancer-genomics-to-inform-human-oncology/378552/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/leading-the-pack-best-practices-in-comparative-canine-cancer-genomics-to-inform-human-oncology/378552.png","ImageObject",300,407,{"name":42,"@type":43},"PakDamar76","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are pet dogs considered an important model for comparative cancer research?","Question",{"text":63,"@type":64},"Pet dogs develop spontaneous cancers at a much higher rate than humans and share key features with human cancers, including molecular drivers, heterogeneity, treatment response, resistance/recurrence, and metastasis patterns. Their intact immune system and longitudinal follow-up further support translational studies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What previously limited effective utilization of pet dog cancers?",{"text":68,"@type":64},"Effective use was hindered by a limited set of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a lack of information about the genomic landscape of canine cancers.",{"name":70,"@type":61,"acceptedAnswer":71},"What recent resources and tools address those limitations?",{"text":72,"@type":64},"Advances include the generation of a highly annotated canine reference genome, creation of tools for multi-omic analysis of canine tumors, and development of a centralized repository for genomic and clinical data through the Integrated Canine Data Commons.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378552,1790652077,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":98},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>Vet Comp Oncol. Author manuscript; available in PMC 2025 May 10. |\n| --- | --- |\n\nPublished in final edited form as:  \nVet Comp Oncol. 2023 December ; 21(4): 565–577. doi:10.1111/vco.12935 .  \nLeading the pack: Best practices in comparative canine cancer genomics to inform human oncology  \nCheryl A. London 1 , Heather Gardner1 , Shaying Zhao2 , Deborah W. Knapp3 , Sagar M. Utturkar4 , Dawn L. Duval5 , Melissa R. Chambers6 , Elaine Ostrander7 , Jeffrey M. Trent8 , Gina Kuffel9  \n1Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA  \n2 University of Georgia Cancer Center, University of Georgia, Athens, Georgia, USA  \n3College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA  \n4 Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana, USA  \n5College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA  \n6School of Medicine, University of Alabama, Birmingham, Alabama, USA  \n7Cancer Genetics and Comparative Genomics Branch, National Cancer Institute, Bethesda, Maryland, USA  \n8Translational Genomics Research Institute, Phoenix, Arizona, USA  \n9 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA  \nAbstract  \nPet dogs develop spontaneous cancers at a rate estimated to be five times higher than that of humans, providing a unique opportunity to study disease biology and evaluate novel therapeutic strategies in a model system that possesses an intact immune system and mirrors key aspects of human cancer biology. Despite decades of interest, effective utilization of pet dog cancers has been hindered by a limited repertoire of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a dearth of information regarding the genomic landscape of these cancers. Recently, many of these critical gaps have been addressed through the generation of a highly annotated canine reference genome, the creation of several tools necessary for multi-omic analysis of canine tumours, and the development of a centralized repository for key genomic and associated clinical information from canine cancer patients, the Integrated Canine Data Commons.  \nTogether, these advances have catalysed multidisciplinary efforts designed to integrate the study of pet dog cancers more effectively into the translational continuum, with the ultimate goal of  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Correspondence: Cheryl A. London, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, [USA. cheryl.london@tufts.edu](USA. cheryl.london@tufts.edu).  \nCONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nLondon et al. Page 2  \nimproving human outcomes. The current review summarizes this recent progress and provides a guide to resources and tools available for comparative study of pet dog cancers.  \nKeywords  \ncanine genome; data analysis; tumour genomics  \n1 | INTRODUCTION  \nMouse models of cancer have been instrumental for dissecting biological processes that underlie tumorigenesis. However, these often lack key features of spontaneous disease including treatment-induced resistance and multi-focal metastases that sometimes occurs a decade or longer post therapy. More recently, genetically engineered mice and humanized models have supported interrogation of novel therapeutic approaches in settings that more closely recapitulate human cancers.1,2 Despite these improvements, the complexities of c","cbCaibK1QdCvq1RF","https://ap.wps.com/l/cbCaibK1QdCvq1RF","pdf",662963,24,"English","# Abstract\n# Introduction\n## Limitations of existing cancer models\n## Relevance of spontaneous canine cancers\n## Translational value and ongoing research","[{\"question\":\"Why are pet dogs considered an important model for comparative cancer research?\",\"answer\":\"Pet dogs develop spontaneous cancers at a much higher rate than humans and share key features with human cancers, including molecular drivers, heterogeneity, treatment response, resistance/recurrence, and metastasis patterns. Their intact immune system and longitudinal follow-up further support translational studies.\"},{\"question\":\"What previously limited effective utilization of pet dog cancers?\",\"answer\":\"Effective use was hindered by a limited set of necessary cellular and molecular reagents for both in vitro and in vivo studies, as well as a lack of information about the genomic landscape of canine cancers.\"},{\"question\":\"What recent resources and tools address those limitations?\",\"answer\":\"Advances include the generation of a highly annotated canine reference genome, creation of tools for multi-omic analysis of canine tumors, and development of a centralized repository for genomic and clinical data through the Integrated Canine Data Commons.\"}]","Leading the pack - Best practices in comparative canine cancer genomics to inform human oncology | PDF",1790231142]