[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338069-105":59,"doc-detail-338069-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","latest-research-progress-of-liquid-biopsy-in-tumor-a-narrative-review","Latest Research Progress of Liquid Biopsy in Tumor - A Narrative Review","","Human life expectancy is significantly impacted by cancer, and liquid biopsy has emerged as a noninvasive option with high diagnostic accuracy, easy sampling, and cost-effectiveness versus tissue biopsy. It supports early detection, real-time monitoring, and personalized therapy across multiple cancers, tracking tumor progression through circulating tumor DNA, circulating tumor cells, and exosomes. This narrative review summarizes the past three years of advances in key liquid biopsy markers and their detection methods, clinical applications, DNA methylation roles, and adoption challenges for routine practice.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/latest-research-progress-of-liquid-biopsy-in-tumor-a-narrative-review/338069/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/latest-research-progress-of-liquid-biopsy-in-tumor-a-narrative-review/338069.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes liquid biopsy advantageous compared with conventional tissue biopsy?","Question",{"text":112,"@type":113},"Liquid biopsy is noninvasive, offers high precision, involves minimal sampling risk, fewer sampling constraints, and simpler sample preparation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biomarkers does the review focus on for liquid biopsy in tumors?",{"text":117,"@type":113},"The review highlights circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes, and further discusses DNA methylation biomarkers for clinical applications.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical roles does liquid biopsy aim to support in cancer management?",{"text":121,"@type":113},"It is intended for early detection, therapy response prediction, treatment monitoring, prognostication, and relevance to minimal residual disease, while also addressing challenges for routine clinical adoption.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338069,1790431070,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Cancer Management and Research  \nOpen Access Full Text Article REVIEW  \nLatest Research Progress of Liquid Biopsy in Tumor—A Narrative Review  \nHua Jiang   \nDepartment of Urology, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), Zhuhai, People’s Republic of China  \nCorrespondence: Hua Jiang, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), No. 1439, Zhufeng Road, Zhuhai, 519100, People’s Republic of China, Tel +8613726205880,, [Email yonghongjiang@163.com](Email yonghongjiang@163.com)  \n\n| Abstract: Human life expectancy is significantly impacted by cancer, with liquid biopsy emerging as an advantageous method for cancer detection because of its noninvasive nature, high accuracy, ease of sampling, and cost-effectiveness compared with conventional tissue biopsy techniques. Liquid biopsy shows promise in early cancer detection, real-time monitoring, and personalized treatment for various cancers, including lung, cervical, and prostate cancers, and offers innovative approaches for cancer diagnosis and management. By utilizing circulating tumor DNA, circulating tumor cells, and exosomes as biomarkers, liquid biopsy enables the tracking of cancer progression. Various techniques commonly used in life sciences research, such as polymerase chain reaction (PCR), next-generation sequencing (NGS), and droplet digital PCR, are employed to assess cancer progression on the basis of different indicators. This review examines the latest advancements in liquid biopsy markers—circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes—for cancer diagnosis over the past three years, with a focus on their detection methodologies and clinical applications. It encapsulates the pivotal aims of liquid biopsy, including early detection, therapy response prediction, treatment monitoring, prognostication, and its relevance in minimal residual disease, while also addressing the challenges facing routine clinical adoption. By combining the latest research advancements and practical clinical experiences, this work focuses on discussing the clinical significance of DNA methylation biomarkers and their applications in tumor screening, auxiliary diagnosis, companion diagnosis, and recurrence monitoring. These discussions may help enhance the application of liquid biopsy throughout the entire process of tumor diagnosis and treatment, thereby providing patients with more precise and effective treatment plans.\u003Cbr>Keywords: liquid biopsy, circulating tumor DNA, circulating tumor cells, exosomes, DNA methylation |\n| --- |\n| Introduction\u003Cbr>The latest report titled “Global cancer burden growing, amidst mounting need for services” was released by the International Agency for Research on Cancer (IARC) of the World Health Organization on February 2, 2024, highlighting the increasing global cancer burden, which requires urgent attention worldwide.1 Based on current data, the IARC has projected and expressed new concerns that the global cancer burden is anticipated to escalate further by 2050. The data suggest that by 2050, approximately 25 years from now, the number of new cancer cases is expected to surpass 35 million, representing a 77% increase from 20 million cases in 2022. Concomitantly, by 2050, the mortality rate from cancer is likely to double.\u003Cbr>Liquid biopsy is a noninvasive biomarker detection technology that was defined as an early cancer detection method in 2013.2 It is commonly used for the detection of early-stage cancer, offering the advantage of detecting cancer before symptoms appear. Liquid biopsy is also used in late-stage cancer treatment decisions. Compared with tissue biopsy, liquid biopsy offers notable benefits, including noninvasiveness, high precision, minimal sampling risk, fewer sampling constraints, and straightforward sample preparation. In contrast to conventional cancer detection approaches, liquid biopsy has been extensively used in n","cbCaiiztcxDUOqFN","https://ap.wps.com/l/cbCaiiztcxDUOqFN","pdf",2252576,12,"English","# Introduction\n## Liquid biopsy definition and advantages\n## Biomarkers and sample types\n# Abstract overview\n## Biomarker categories\n## Techniques and clinical uses","[{\"question\":\"What makes liquid biopsy advantageous compared with conventional tissue biopsy?\",\"answer\":\"Liquid biopsy is noninvasive, offers high precision, involves minimal sampling risk, fewer sampling constraints, and simpler sample preparation.\"},{\"question\":\"Which biomarkers does the review focus on for liquid biopsy in tumors?\",\"answer\":\"The review highlights circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes, and further discusses DNA methylation biomarkers for clinical applications.\"},{\"question\":\"What clinical roles does liquid biopsy aim to support in cancer management?\",\"answer\":\"It is intended for early detection, therapy response prediction, treatment monitoring, prognostication, and relevance to minimal residual disease, while also addressing challenges for routine clinical adoption.\"}]","Latest Research Progress of Liquid Biopsy in Tumor - A Narrative Review | PDF",1790021819]