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The review summarizes current evidence on fatal and morbid late complications and their impact on morbidity, mortality, social and economic health, and life expectancy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/late-side-effects-of-testicular-cancer-and-treatment-a-comprehensive-review/337009/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/late-side-effects-of-testicular-cancer-and-treatment-a-comprehensive-review/337009.png","ImageObject",300,407,{"name":42,"@type":43},"Quinn","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are late side effects a significant concern for testicular cancer survivors?","Question",{"text":63,"@type":64},"Because testicular cancer has high cure rates and many patients live for decades after treatment, treatment-related complications can emerge later and affect survival and multiple aspects of life.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which treatments are discussed as drivers of late side effects in the review?",{"text":68,"@type":64},"The review highlights late effects associated with surgery, radiotherapy, and chemotherapy, including cisplatin-based chemotherapy regimens.",{"name":70,"@type":61,"acceptedAnswer":71},"What late complications are included among the review’s key examples?",{"text":72,"@type":64},"The review lists complications such as second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, and psychological conditions including stress and anxiety.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337009,1790114783,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nLate side effects of testicular cancer and treatment: a comprehensive review  \nM. Raheel Khan1 · Patrice Kearney Sheehan1 · Ashley Bazin1 · Christine Leonard1 · Umair Aleem4 · Lynda Corrigan1 · Ray McDermott1,2,3  \nReceived: 27 January 2024 / Accepted: 6 November 2024  \n© The Author(s) 2024 OPEN  \nAbstract  \nTesticular cancer is a rare solid organ tumour associated with high cure rates and young age at diagnosis, hence it has a sizeable cohort of survivors worldwide. As it is one of the earliest tumours to be cured, a lot of studies have highlighted the late side effects of cancer and its different treatment modalities including surgery, radiotherapy and chemotherapy. While we are trying to identify the population at higher risk of platinum based chemotherapy and reduce its exposure, cisplatin based regimes remain an important tool to cure testicular cancer. The list of late side effects include a number of fatal and morbid conditions including but not limited to the second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, infertility and psychological illnesses like stress and anxiety. These complications eventually result in compromised social and economic health as well as lower life expectancy compared to the normal population. This article provides a comprehensive review of the latest data regarding the late side effects in testicular cancer survivors. A review of these conditions can help us develop recommendations and guidelines to improve the morbidity and mortality in survivors of testicular cancer.  \nKeywords Testicular cancer · Cancer survivorship · Germ cell tumours · Chemotherapy late side-effect  \n1 Introduction  \nTesticular cancer (TC) is a rare tumour, accounting for only 1% of solid organ tumours, but its incidence has been increasing globally in the last two decades especially in the developed countries coupled with an improvement in mortality rates [1, 2] . Most of testicular cancers are germ cell tumours (97%) [3], usually diagnosed at an early age [4] . In general, the cure rates are around 95%[5], resulting in a large population of patients who will live for decades in the survivorship phase after the treatment of cancer. Different treatment modalities used in treatment, including surgery, radiotherapy and chemotherapy, are all associated with significant morbidity and mortality in the survivorship setting. Most commonly reported conditions include second malignant neoplasms, cardiovascular disease, persistent peripheral neuropathy, hypogonadism, chronic pulmonary disease, ototoxicity, nephrotoxicity and psychiatric disorders including anxiety and  \n* M. Raheel Khan, [mraheelhashim@hotmail.com](mraheelhashim@hotmail.com); Patrice Kearney Sheehan, [patrice.kearneysheehan@tuh.ie](patrice.kearneysheehan@tuh.ie); Ashley Bazin,  \n[ashley.bazin@tuh.ie](ashley.bazin@tuh.ie); Christine Leonard, [christine.leonard@tuh.ie](christine.leonard@tuh.ie); Umair Aleem, [umair.aleem@nhs.net](umair.aleem@nhs.net); Lynda Corrigan, lynda.corrigan@  \n[tuh.ie](tuh.ie); Ray McDermott, [Ray.McDermott@tuh.ie |](Ray.McDermott@tuh.ie |1Department of Medical Oncology)[1](Ray.McDermott@tuh.ie |1Department of Medical Oncology)[Department of Medical Oncology](Ray.McDermott@tuh.ie |1Department of Medical Oncology), Tallaght University Hospital, Tallaght, Dublin, Republic of Ireland. 2School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, Ireland. 3Department of Medical Oncology, St. Vincent’s University Hospital, Elm Park, Dublin D04 YN26, Ireland. 4Department of Medical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Withington, Manchester M20 4BX, UK.  \nDiscover Oncology  \n(2024) 15:646  \n| [https://doi.org/10.1007/s12672-024-01549-1](https://doi.org/10.1007/s12672-024-01549-1)  \ndepression [6–8]. These late sequelae on one hand cause lower than normal life expectan","cbCaitSxV3jrNPsd","https://ap.wps.com/l/cbCaitSxV3jrNPsd","pdf",813817,13,"English","# Introduction\n# Treatment overview","[{\"question\":\"Why are late side effects a significant concern for testicular cancer survivors?\",\"answer\":\"Because testicular cancer has high cure rates and many patients live for decades after treatment, treatment-related complications can emerge later and affect survival and multiple aspects of life.\"},{\"question\":\"Which treatments are discussed as drivers of late side effects in the review?\",\"answer\":\"The review highlights late effects associated with surgery, radiotherapy, and chemotherapy, including cisplatin-based chemotherapy regimens.\"},{\"question\":\"What late complications are included among the review’s key examples?\",\"answer\":\"The review lists complications such as second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, and psychological conditions including stress and anxiety.\"}]","Late side effects of testicular cancer and treatment - a comprehensive review | PDF",1790017377,33]