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Endoscopic resection methods—endoscopic mucosal resection, endoscopic submucosal dissection, and endoscopic full-thickness resection—enable organ-preserving management with encouraging outcomes. The editorial discusses real-world evidence from advanced endoscopic approaches, highlighting safety, effectiveness, complete resection prospects, and adverse-event acceptability.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/large-colorectal-lesions-expanding-the-boundaries-of-endoscopic-management-editorial/406419/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/large-colorectal-lesions-expanding-the-boundaries-of-endoscopic-management-editorial/406419.png","ImageObject",300,407,{"name":92,"@type":93},"Cart","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are large colorectal lesions difficult to manage endoscopically?","Question",{"text":113,"@type":114},"Large colorectal lesions (≥ 3 cm) carry malignancy potential and present technical difficulties, making complete and effective removal challenging.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which endoscopic resection techniques are emphasized for large colorectal lesions?",{"text":118,"@type":114},"The editorial highlights endoscopic mucosal resection, endoscopic submucosal dissection, and endoscopic full-thickness resection as key organ-preserving approaches.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the editorial position advanced endoscopic resection compared with surgery?",{"text":122,"@type":114},"Findings support high complete resection rates with acceptable adverse events, reinforcing endoscopic strategies and suggesting a shift from surgical to organ-preserving management in colorectal oncology.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406419,1790740696,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | G | E | World Journal of\u003Cbr>Gastrointestinal Endoscopy |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Endosc 2025 December 16; 17(12): 115008  \nDOI: 10.4253/wjge.v17.i12.115008 ISSN 1948-5190 (online)  \nEDITORIAL  \nLarge colorectal lesions: Expanding the boundaries of endoscopic management  \nAmit Bagrodia, Venkatesh Vaithiyam, Supraja Laguduva Mohan  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A  \nNovelty: Grade A, Grade A  \nCreativity or Innovation: Grade A, Grade A  \nScientific Significance: Grade A, Grade A  \nP-Reviewer: Ibrahim M, MD, Associate Professor, Chief Physician, Egypt  \nReceived: October 9, 2025  \nRevised: November 14, 2025  \nAccepted: December 3, 2025  \nPublished online: December 16, 2025  \nProcessing time: 72 Days and 12.6 Hours  \nAmit Bagrodia, Venkatesh Vaithiyam, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India  \nSupraja Laguduva Mohan, Department of Radiology, All India Institute of Medical Sciences, New Delhi 110024, Delhi, India  \nCorresponding author: Venkatesh Vaithiyam, DM, MD, Assistant Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, 1, JLN Marg, Raj Ghat, New Delhi 110002, Delhi, India.  \n[venkateshvaithiyam172@gmail.com](venkateshvaithiyam172@gmail.com)  \nAbstract  \nLarge colorectal lesions (≥ 3 cm) present a significant therapeutic challenge due to their potential for malignancy and the technical difficulties they encounter. Endoscopic resection techniques, including endoscopic mucosal resection, endoscopic submucosal dissection, and endoscopic full-thickness resection, have revolutionized the management of these lesions by offering organ-preserving alternatives to surgery with favorable outcomes. We read with great interest and commended Zhu et al for their valuable study on the endoscopic treatment of large colorectal lesions. Zhu et al’s study provides crucial real-world evidence regarding the safety and effectiveness of advanced endoscopic resection techniques in this challenging patient group. These findings support the possibility of achieving high rates of complete resection with acceptable adverse event profiles, reinforcing the role of endoscopic mucosal resection and submucosal dissection in routine practice. This editorial also offers a comprehensive review of the current literature, discusses its clinical implications, explores future directions, and compares endoscopic resection methods with surgical options. Zhu et al’s study findings not only validate the efficacy of advanced endoscopic resection but also signify a paradigm shift from surgical to organ-preserving strategies in colorectal oncology, a transformation that requires deliberate system-wide training and capacity building.  \nKey Words: Large colorectal lesion; Endoscopic management; Endoscopic mucosal resection; Endoscopic submucosal dissection; Endoscopic full thickness resection; Laterally spreading tumors  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJGE  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 16, 2025  Volume 17  Issue 12   \nBagrodia A et al. Endoscopic management of large colorectal lesion  \nCore Tip: Large colorectal lesions constitute a distinct group with increased potential for malignancy, and their removal is technically challenging for endoscopists. Endoscopic mucosal resection is fundamental for many benign lesions; however, the risk of recurrence necessitates complete resection of lesion margins. Endoscopic submucosal dissection provides higher en bloc rates with oncological safety, whereas endosco","cbCaity3ExmpO5qV","https://ap.wps.com/l/cbCaity3ExmpO5qV","pdf",880994,"English","# Large colorectal lesions: Expanding the boundaries of endoscopic management\n## Editorial focus\n## Endoscopic resection techniques and clinical implications\n## Comparison with surgical options and future directions","[{\"question\":\"Why are large colorectal lesions difficult to manage endoscopically?\",\"answer\":\"Large colorectal lesions (≥ 3 cm) carry malignancy potential and present technical difficulties, making complete and effective removal challenging.\"},{\"question\":\"Which endoscopic resection techniques are emphasized for large colorectal lesions?\",\"answer\":\"The editorial highlights endoscopic mucosal resection, endoscopic submucosal dissection, and endoscopic full-thickness resection as key organ-preserving approaches.\"},{\"question\":\"How does the editorial position advanced endoscopic resection compared with surgery?\",\"answer\":\"Findings support high complete resection rates with acceptable adverse events, reinforcing endoscopic strategies and suggesting a shift from surgical to organ-preserving management in colorectal oncology.\"}]","Large colorectal lesions - Expanding the boundaries of endoscopic management - Editorial | PDF",1790565565,25]