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A 72-year-old man presented with constipation and right upper quadrant pain; imaging showed an ill-defined gallbladder lesion extending into the liver, and biopsy with immunohistochemistry confirmed LCNEC. Palliative chemotherapy was initiated, emphasizing careful evaluation of asymptomatic gallstones.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/large-cell-neuroendocrine-carcinoma-of-the-gallbladder-where-survival-is-a-rare-entity-case-report-and-review-of-the-literature/383067/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/large-cell-neuroendocrine-carcinoma-of-the-gallbladder-where-survival-is-a-rare-entity-case-report-and-review-of-the-literature/383067.png","ImageObject",300,407,{"name":42,"@type":43},"Ben ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is large cell neuroendocrine carcinoma of the gallbladder considered rare?","Question",{"text":63,"@type":64},"The document states carcinoma of the gallbladder is extremely rare, and neuroendocrine neoplasms represent only about 0.5% of gallbladder cancers. LCNEC is even rarer, with the presented case described as the 15th in the literature.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What symptoms and key findings were reported in the case presentation?",{"text":68,"@type":64},"A 72-year-old male presented with constipation and right upper quadrant pain for three months. CT imaging showed an ill-defined 7.2 × 4.9 cm hypodense gallbladder lesion extending into the liver, and laboratory tests showed elevated liver-related enzymes.",{"name":70,"@type":61,"acceptedAnswer":71},"How was the diagnosis of large cell neuroendocrine carcinoma confirmed?",{"text":72,"@type":64},"Histopathological evaluation of the biopsy and immunohistochemical staining confirmed LCNEC. Tumor cells were positive for markers including CD56, synaptophysin, chromogranin, CK20, and Ki67, and negative for TTF1 and CK7 to favor gastrointestinal origin.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},383067,1790751133,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Case Reports in Gastroenterology  \n\n| Case Rep Gastroenterol 2023;17:333–338 |  |\n| --- | --- |\n| DOI: 10.1159/000534520\u003Cbr>Received: January 5, 2023\u003Cbr>Accepted: October 6, 2023\u003Cbr>Published online: November 16, 2023 | © 2023 The Author(s) .\u003Cbr>Published by S. Karger AG, Basel [www.karger.com/crg](www.karger.com/crg) |\n\nThis article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) ([http://www.karger.com/Services/OpenAccessLicense](http://www.karger.com/Services/OpenAccessLicense)). Usage and distribution for commercial purposes requires written permission.  \nCase Report  \nLarge Cell Neuroendocrine Carcinoma of the Gallbladder: Where Survival Is a Rare Entity – Case Report and Review of the Literature  \nSamyak Dhruva Kuldeepsinh P. Atodaria b Indraneil Mukherjeec Anil Kankaria d Umed K. Shah e  \na Hospitalist at MedStar St. Mary’s Hospital, Leonardtown, MD, USA; b3rd Year Internal Medicine Resident at Abington Health, Abington, PA, USA; cAttending Foregut and HPB Surgeon at Staten Island University Hospital, New York, NY, USA; dGastroenterologist at MedStar St. Mary’s Hospital, Leonardtown, MD, USA; eAssistant Clinical Professor of Gastroenterology, Georgetown University Hospital, Washington, DC, USA  \nKeywords  \nNeuroendocrine carcinoma · Large cell carcinoma · Gallbladder cancer · Asymptomatic gallstones  \nAbstract  \nIntroduction: Carcinoma of the gallbladder is extremely rare, papillary adenocarcinoma comprises 90% of these cases. Although neuroendocrine neoplasms (NENs) comprise 0.5% of the cases of gallbladder cancer, the incidence is rising. NEN is classified into a well-differentiated neuroendocrine tumor and poorly differentiated neuroendocrine cancer (NEC) . Histologically, NEC is small-cell or large-cell carcinoma. We present the extremely rare case, 15th in the literature to be precise, of large cell neuroendocrine carcinoma of the gallbladder. Case Presentation: A 72-year-old male presented to the emergency department with constipation and right upper quadrant pain for 3 months. Computed tomography scan of the abdomen demonstrated an ill-defined 7.2 × 4.9 cm hypodense lesion in the gallbladder fossa with extension into the liver. Histopathological and immunohistochemical analysis of the biopsy specimen confirmed the diagnosis of large cell neuroendocrine carcinoma of the gallbladder. He was started on palliative chemotherapy. Conclusion: The plethora of tumors present in the gallbladder necessitates a search for risk factors for gallbladder neoplasia, and underscores the need to more carefully examine the nature of “asymptomatic gallstones.”  \nSamyak Dhruv was also awarded outstanding poster presenter for this rare case at ACG (American Journal of Gastroenterology) 2020 .  \nCorrespondence to:  \nSamyak Dhruv, [samyakdhruv92](samyakdhruv92@ gmail.com)[@](samyakdhruv92@ gmail.com)[ gmail.com](samyakdhruv92@ gmail.com)  \nCase Reports in Gastroenterology  \nCase Rep Gastroenterol 2023;17:333–338 334  \n\n| DOI: 10.1159/000534520 | © 2023 The Author(s) . Published by S. Karger AG, Basel [www.karger.com/crg](www.karger.com/crg) |\n| --- | --- |\n\nDhruv et al.: Large Cell Neuroendocrine Carcinoma  \nFurther studies may reveal subclasses of cholelithiasis, gallbladder morphology, or imaging to define which patients should be followed more carefully, and may clarify additional risk factors for cancer of the gallbladder.  \n© 2023 The Author(s) .  \nPublished by S. KargerAG, Basel  \nIntroduction  \nCarcinoma of the gallbladder (GB) is extremely rare: papillary adenocarcinoma being the most common comprises 90% of the GB cancers. Neuroendocrine neoplasms (NENs) comprise only0.5%ofthe cases ofthe GB cancer, and the incidence is rising[1]. NEN isclassified into a welldifferentiated neuroendocrine tumor (NET) and poorly differentiated neuroendocrine cancer (NEC). NEC is divided based on histopathology into small-cell and large-cell NEC. NET is a rare heterogenous neoplasm that originates fr","cbCaigaLsXdCmfQ3","https://ap.wps.com/l/cbCaigaLsXdCmfQ3","pdf",743325,"English","# Abstract\n## Introduction\n## Case Presentation\n## Conclusion\n# Case Report\n## Patient presentation\n## Imaging and diagnostic findings\n# References and figure discussion","[{\"question\":\"Why is large cell neuroendocrine carcinoma of the gallbladder considered rare?\",\"answer\":\"The document states carcinoma of the gallbladder is extremely rare, and neuroendocrine neoplasms represent only about 0.5% of gallbladder cancers. LCNEC is even rarer, with the presented case described as the 15th in the literature.\"},{\"question\":\"What symptoms and key findings were reported in the case presentation?\",\"answer\":\"A 72-year-old male presented with constipation and right upper quadrant pain for three months. CT imaging showed an ill-defined 7.2 × 4.9 cm hypodense gallbladder lesion extending into the liver, and laboratory tests showed elevated liver-related enzymes.\"},{\"question\":\"How was the diagnosis of large cell neuroendocrine carcinoma confirmed?\",\"answer\":\"Histopathological evaluation of the biopsy and immunohistochemical staining confirmed LCNEC. Tumor cells were positive for markers including CD56, synaptophysin, chromogranin, CK20, and Ki67, and negative for TTF1 and CK7 to favor gastrointestinal origin.\"}]","Large Cell Neuroendocrine Carcinoma of the Gallbladder: Where Survival Is a Rare Entity - Case Report and Review of the Literature | PDF",1790253956,15]