[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376383-105":59,"doc-detail-376383-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","lactylation-as-a-cross-regulatory-node-in-tumor-metabolism-and-epigenetics-insights-and-therapeutic-implications","Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications","","Lactylation is a pivotal cross-regulatory mechanism linking tumor metabolic reprogramming with epigenetic regulation. This review summarizes lactylation writers, erasers, and readers, and delineates tumor-specific functions, especially in remodeling the immunosuppressive tumor microenvironment and driving therapeutic resistance. Mechanistic evidence highlights lactylation as a conduit translating metabolic status into heritable gene-expression programs. Emerging targeting strategies combining metabolic inhibition, epigenetic modulation, and immunotherapy show strong preclinical promise for clinical translation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/lactylation-as-a-cross-regulatory-node-in-tumor-metabolism-and-epigenetics-insights-and-therapeutic-implications/376383/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/lactylation-as-a-cross-regulatory-node-in-tumor-metabolism-and-epigenetics-insights-and-therapeutic-implications/376383.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does lactylation play in connecting tumor metabolism and epigenetic regulation?","Question",{"text":113,"@type":114},"Lactylation directly links metabolic status to gene expression and protein function by coupling lactic acid–derived lactyl groups to lysine residues, thereby influencing tumorigenesis and immune evasion.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the tumor microenvironment affect lactylation in immune cells?",{"text":118,"@type":114},"Accumulated lactic acid in the tumor microenvironment induces lactylation in immune cells, reshaping an immunosuppressive tumor microenvironment and promoting immune evasion.",{"name":120,"@type":111,"acceptedAnswer":121},"What therapeutic strategies are discussed to target lactylation?",{"text":122,"@type":114},"The review highlights emerging strategies including metabolic inhibitors, epigenetic modulators, and combination immunotherapies aimed at overcoming therapy resistance and improving cancer immunotherapy outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376383,1790254015,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","TYPE Review  \nPUBLISHED 25 September 2025 DOI 10.3389/fimmu.2025.1675480  \nOPEN ACCESS  \nEDITED BY  \nKeqiang Chen,  \nNational Cancer Institute at Frederick (NIH), United States  \nREVIEWED BY  \nRuoxi Yuan,  \nHospital for Special Surgery, United States Amit Kumar Singh,  \nNational Cancer Institute at Frederick (NIH), United States  \n*CORRESPONDENCE  \nJunna Jiao  \n[jiaonajd@163.com](jiaonajd@163.com)  \nRECEIVED 29 July 2025  \nACCEPTED 04 September 2025  \nPUBLISHED 25 September 2025  \nCITATION  \nLv Z, Yang R, Liu L, Shi X, Wang R, Wu J and Jiao J (2025) Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications.  \nFront. Immunol. 16:1675480 .  \ndoi: 10.3389/fimmu.2025.1675480  \nCOPYRIGHT  \n© 2025 Lv, Yang, Liu, Shi, Wang, Wu and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nLactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications  \nZhuangwei Lv 1, Ruohao Yang2, Lulu Liu 3, Xiaoyu Shi 3, Ruihan Wang 3, Jinhua Wu 2 and Junna Jiao 2,4*  \n1School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China, 2School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China, 3School of Junji College, Xinxiang Medical University, Xinxiang, Henan, China, 4Xinxiang Engineering Technology Research Center of Immune Checkpoint Drugs for Liver-Intestinal Tumors, Xinxiang Medical University, Xinxiang, China  \nLactylation serves as a pivotal cross-regulatory mechanism linking tumor metabolic reprogramming and epigenetic regulation . This review comprehensively summarizes the mechanisms of lactylation writers, erasers, and readers, highlighting their tumor-spec ific functions, roles in immunosuppress ive tumor microenvironment (TME) remodeling, and contributions to therapeutic resistance . Emerging targeting strategies, including metabolic inhibitors, epigenetic modulators, and combination immunotherapies, exhibit promising preclinical efficacy, highlighting their potential for clinical translation in overcoming therapy resistance and improving cancer immunotherapy.  \nKEYWORDS  \nlactylation, metabolic reprogramming, epigenetic regulation, Warburg effect, therapeutic  \n1 Introduction  \nThe crosstalk between tumor metabolic reprogramming and epigenetic regulation represents a core focus in contemporary cancer research. The landmark discovery oflysine lactylation (Kla) in 2019 provided a breakthrough in this field, revealing a direct molecular link between lactic acid—a classic end-product of glycolysis—and the regulation of gene expression (1–7) . Previously regarded primarily as a metabolic waste product, lactic acid, through lactylation modification, has emerged as a key molecule connecting aberrant tumor metabolism to epigenetic remodeling (8) . This post-translational modification plays a central role in tumorigenesis, progression, immune evasion, and therapeutic resistance by transducing cellular metabolic status into heritable gene expression patterns (1, 9–13) .  \nAccumulating evidence confirms that lactylation is abnormally activated across diverse tumor types, with its levels closely correlating with tumor malignancy, patient prognosis, and therapeutic response (14) . Mechanistically, lactylation regulates downstream target  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \ngene transcription via histone modification or alters protein function through non-histone modification, thereby participating in critical biological processes such as tumor cell proliferation, apoptosis, invasion, and metastasis","cbCaiuIRU1ijG3MG","https://ap.wps.com/l/cbCaiuIRU1ijG3MG","pdf",6425025,17,"English","# Introduction\n## Molecular mechanisms and regulatory networks of lactylation\n### Catalytic and reverse mechanisms of lactylation","[{\"question\":\"What role does lactylation play in connecting tumor metabolism and epigenetic regulation?\",\"answer\":\"Lactylation directly links metabolic status to gene expression and protein function by coupling lactic acid–derived lactyl groups to lysine residues, thereby influencing tumorigenesis and immune evasion.\"},{\"question\":\"How does the tumor microenvironment affect lactylation in immune cells?\",\"answer\":\"Accumulated lactic acid in the tumor microenvironment induces lactylation in immune cells, reshaping an immunosuppressive tumor microenvironment and promoting immune evasion.\"},{\"question\":\"What therapeutic strategies are discussed to target lactylation?\",\"answer\":\"The review highlights emerging strategies including metabolic inhibitors, epigenetic modulators, and combination immunotherapies aimed at overcoming therapy resistance and improving cancer immunotherapy outcomes.\"}]","Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications | PDF",1790218530,43]