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Obesity predisposes children to metabolic disorders such as diabetes and hypertension, which may reduce transplant eligibility and complicate peri-transplant management. It can also alter drug pharmacokinetics for rejection prevention and contribute to higher rates of post-transplant complications and rejection. Evidence shows mixed signals on graft survival, underscoring the need for optimized, weight-conscious strategies to improve outcomes for children requiring renal replacement therapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/kidney-transplant-outcomes-in-obese-pediatric-patients-editorial/406671/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/kidney-transplant-outcomes-in-obese-pediatric-patients-editorial/406671.png","ImageObject",300,407,{"name":92,"@type":93},"4398046744996","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why does pediatric obesity matter for kidney transplant outcomes?","Question",{"text":113,"@type":114},"Pediatric obesity is linked to metabolic comorbidities that can impair graft survival and long-term overall health, affecting transplant readiness and recovery.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which obesity-related conditions can influence transplantation in children?",{"text":118,"@type":114},"Obesity can lead to metabolic disorders such as diabetes and hypertension, which may make children less suitable for transplantation or increase procedural difficulty.",{"name":120,"@type":111,"acceptedAnswer":121},"How can obesity affect post-transplant management and risk?",{"text":122,"@type":114},"Obesity may change the pharmacokinetics of drugs used to prevent rejection, and clinical evidence suggests higher risks of post-transplant complications, including rejection.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406671,1790789917,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":66,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},4398046744996,"| W | J | N | World Journal of\u003Cbr>Nephrology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Nephrol 2025 December 25; 14(4): 106536  \nDOI: 10.5527/wjn.v14.i4.106536 ISSN 2220-6124 (online)  \n\n| Kidney transplant outcomes in obese pediatric patients\u003Cbr>Guido Gembillo, Lorenzo Lo Cicero, Domenico Santoro | EDITORIAL |\n| --- | --- |\n\nSpecialty type: Urology and nephrology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B  \nNovelty: Grade A, Grade B  \nCreativity or Innovation: Grade A, Grade B  \nScientific Significance: Grade A, Grade A  \nP-Reviewer: Li N  \nReceived: March 3, 2025  \nRevised: April 10, 2025  \nAccepted: May 13, 2025  \nPublished online: December 25, 2025  \nProcessing time: 298 Days and 5.2 Hours  \nGuido Gembillo, Domenico Santoro, Unit of Nephrology and Dialysis, AOU \"G. Martino\", University of Messina, Messina 98125, Sicilia, Italy  \nLorenzo Lo Cicero, Department of Clinical and Experimental Medicine, University of Messina, Messina 98121, Sicilia, Italy  \nCorresponding author: Guido Gembillo, MD, PhD, Unit of Nephrology and Dialysis, AOU \"G. Martino\", University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy.  \n[ggembillo@gmail.com](ggembillo@gmail.com)  \nAbstract  \nThe increasing prevalence of pediatric obesity has raised numerous questions about its health implications, particularly regarding renal transplant outcomes. These complications often hinder medical interventions in these children. While kidney transplants are often viewed from an organocentric perspective, the overall health of the patient is critical to the success of the procedure. Current discussions make it clear that childhood obesity poses significant problems not only for graft survival, but also for long-term overall health. Childhood obesity can lead to many metabolic disorders such as diabetes and hypertension. These conditions can significantly affect a child's suitability for a transplant or make the process more difficult. A child's weight can affect the pharmacokinetics of drugs used to prevent organ rejection. Obesity impacts the individual and sets in motion a cascade of effects that can jeopardize transplant success and recovery, so understanding is needed. Research on graft survival rates is both optimistic and concerning. Clinical studies show that obese children often have an increased risk of post-transplant complications, which affects transplant longevity. The likelihood of rejection may increase due to the metabolic status of an obese child. Due to the allocation of healthcare resources for the treatment of obesity-related diseases, availability for the transplant itself may be limited. Many children maintain an adequate quality of life after a kidney transplant, but excessive weight can significantly affect their health and chances of survival. The main target is looking for highly successful strategies to give all children who need a transplant a better future, regardless of their weight.  \nKey Words: Chronic kidney disease; Renal transplantation; Kidney transplant; Pediatric patients; Obesity; Bariatric surgery; Renal replacement therapies; Diabetes; Nutrition; Nutritional therapy  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJN  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 25, 2025  Volume 14  Issue 4   \nGembillo et al. Kidney transplant in obese pediatric patients  \nCore Tip: Childhood obesity can lead to various metabolic diseases, including diabetes and high blood pressure. These factors can significantly affect a child's suitability for transplantation or make the procedure more difficult. Obesity in pediatric patients at the time of kidney transplantation is associated with loss of the transplant and serious negative consequences that ","cbCaidQis600m52O","https://ap.wps.com/l/cbCaidQis600m52O","pdf",498861,"English","# Abstract\n# Core Tip\n# Introduction","[{\"question\":\"Why does pediatric obesity matter for kidney transplant outcomes?\",\"answer\":\"Pediatric obesity is linked to metabolic comorbidities that can impair graft survival and long-term overall health, affecting transplant readiness and recovery.\"},{\"question\":\"Which obesity-related conditions can influence transplantation in children?\",\"answer\":\"Obesity can lead to metabolic disorders such as diabetes and hypertension, which may make children less suitable for transplantation or increase procedural difficulty.\"},{\"question\":\"How can obesity affect post-transplant management and risk?\",\"answer\":\"Obesity may change the pharmacokinetics of drugs used to prevent rejection, and clinical evidence suggests higher risks of post-transplant complications, including rejection.\"}]","Kidney transplant outcomes in obese pediatric patients - Editorial | PDF",1790567178]