[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-542097-105":59,"doc-detail-542097-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","kidney-disease-in-cancer-survivors-focus-on-hematopoietic-stem-cell-transplantation","Kidney disease in cancer survivors: focus on hematopoietic stem cell transplantation","","Kidney disease and hypertension affect many children and adults with cancer, including patients undergoing hematopoietic stem cell transplantation (HSCT). Although survival has improved, acute kidney injury (AKI) and chronic kidney disease (CKD) continue to drive substantial morbidity and mortality. Injury mechanisms are likely multifactorial, involving chemotherapy, other nephrotoxic drugs, and infections, yet key causes remain unclear. This review highlights thrombotic microangiopathy and BK virus infection as potential idiopathic causes and emphasizes careful monitoring of blood pressure, proteinuria, and kidney function.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/kidney-disease-in-cancer-survivors-focus-on-hematopoietic-stem-cell-transplantation/542097/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/kidney-disease-in-cancer-survivors-focus-on-hematopoietic-stem-cell-transplantation/542097.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-10-10",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why do kidney disease and hypertension remain common after HSCT?","Question",{"text":112,"@type":113},"Kidney disease and hypertension are frequent complications in cancer patients and contribute to morbidity and mortality after HSCT. Despite improved survival, AKI and CKD still occur and remain significant complications.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What factors can lead to kidney injury in HSCT recipients?",{"text":117,"@type":113},"Kidney injury is likely multifactorial, involving conditioning chemotherapy and radiation, exposure to nephrotoxic medications, immune dysregulation and endothelial damage, and infections.",{"name":119,"@type":110,"acceptedAnswer":120},"Which causes of AKI and CKD after HSCT does the review emphasize?",{"text":121,"@type":113},"The review focuses on thrombotic microangiopathy (TMA) and BK virus infection as potential causes of AKI and CKD after HSCT.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},542097,1791807879,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Downloaded from [https://iranpaper.ir](https://iranpaper.ir)  \nJON J Onco-Nephrol 2017; 1(3): 163-169  \nDOI: 10.5301/jo-n.5000031  \nISSN 2399-3693 REVIEW  \nKidney disease in cancer survivors: focus on hematopoietic stem cell transplantation  \nBenjamin L. Laskin1, Sonata Jodele2  \n1 Division of Nephrology, The Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA-USA  \n2 Division of Hematology, Oncology and Blood and Marrow Transplantation, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA-USA  \nABSTRACT  \nKidney disease and hypertension are common among children and adults with cancer, including those undergoing hematopoietic stem cell transplantation (HSCT) . While survival has improved over time for patients receiving a HSCT, acute kidney injury (AKI) and chronic kidney disease (CKD) remain associated with significant morbidity and mortality. The mechanisms leading to kidney disease in this population are likely multifactorial and include chemotherapy, other nephrotoxic medications, and infections. Nevertheless, we still do not completely understand why such a large proportion of patients develop kidney disease after HSCT. The growing field of onco-nephrology allows oncologists, transplant providers, and nephrologists to learn about disease processes and treatments relevant to their respective patient populations. Accordingly, we are learning that several mechanisms of injury affecting HSCT recipients also occur in general nephrology and in kidney transplant recipients. For example, complement dysregulation leading to atypical hemolytic uremic syndrome parallels HSCT-associated thrombotic microangiopathy and BK virus nephropathy occurring after kidney transplant can also lead to CKD in HSCT recipients. This review focuses on thrombotic microangiopathy and BK virus infection as potential causes of AKI and CKD after HSCT, which are currently thought to be idiopathic. These diagnoses require a high index of suspicion, emphasizing the importance of close attention to blood pressure, proteinuria, and the measurement and estimation of kidney function in patients undergoing HSCT.  \nKeywords: Acute kidney injury, BK virus infection, Chronic kidney disease, Hematopoietic cell transplant, Thrombotic microangiopathy  \nIntroduction  \nNephrologists are increasingly consulted for kidney disease that develops in patients with cancer following treatment, especially after hematopoietic stem cell transplantation (HSCT) . Kidney disease and hypertension are common and contribute to the high risk of morbidity and mortality in this population. Patients requiring acute renal replacement therapy have especially high mortality rates and those surviving the acute transplant period have an increased risk of later chronic kidney disease (CKD) (1-3) . While overall survival after HSCT has improved over time, acute kidney injury (AKI) and CKD  \nAccepted: September 13, 2017  \nPublished online: September 28, 2017 Corresponding author:  \nBenjamin L. Laskin  \nDivision of Nephrology The Children’s Hospital of Philadelphia 34th Street and Civic Center Boulevard Philadelphia, PA 19104, USA [laskinb@email.chop.edu](laskinb@email.chop.edu)  \nremain significant complications of transplant in both children and adults.  \nThe pathophysiology of kidney injury in patients with cancer and those receiving an HSCT are not completely understood, but they likely involve a combination of conditioning chemotherapy and radiation, exposure to nephrotoxic medications, immune dysregulation, endothelial damage (thrombotic microangiopathy [TMA] and possibly graft versus host disease [GVHD]), and infections (Tab. I) (2-4) . There are several parallels between the kidney diseases that affect oncology patients and the diagnoses commonly encountered by nephrologists in their general nephrology and kidney transplant patients (Tab. II) . These similarities prov","cbCaiif8fSiO4yOh","https://ap.wps.com/l/cbCaiif8fSiO4yOh","pdf",427623,"English","# Introduction\n## Kidney disease burden after HSCT\n## Pathophysiology and clinical parallels\n## Focus of the review: TMA and BK virus infection\n# Tables\n## Potential causes of AKI and CKD in HSCT recipients\n## Parallels among nephrology, kidney transplant, and HSCT recipients","[{\"question\":\"Why do kidney disease and hypertension remain common after HSCT?\",\"answer\":\"Kidney disease and hypertension are frequent complications in cancer patients and contribute to morbidity and mortality after HSCT. Despite improved survival, AKI and CKD still occur and remain significant complications.\"},{\"question\":\"What factors can lead to kidney injury in HSCT recipients?\",\"answer\":\"Kidney injury is likely multifactorial, involving conditioning chemotherapy and radiation, exposure to nephrotoxic medications, immune dysregulation and endothelial damage, and infections.\"},{\"question\":\"Which causes of AKI and CKD after HSCT does the review emphasize?\",\"answer\":\"The review focuses on thrombotic microangiopathy (TMA) and BK virus infection as potential causes of AKI and CKD after HSCT.\"}]","Kidney disease in cancer survivors: focus on hematopoietic stem cell transplantation | PDF",1791670383,18]