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Single-cell sequencing data are used to separate malignant cells into KHDRBS1-positive and KHDRBS1-negative subsets, revealing distinct expression patterns and functional roles. Results demonstrate that KHDRBS1 positivity tracks with tumor progression and promotes oncogenic phenotypes linked to cell proliferation, migration, immune microenvironment changes, and drug sensitivity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/khdrbs1-as-a-novel-prognostic-signaling-biomarker-influencing-hepatocellular-carcinoma-cell-proliferation-migration-immune-microenvironment-and-drug-sensitivity/333336/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/khdrbs1-as-a-novel-prognostic-signaling-biomarker-influencing-hepatocellular-carcinoma-cell-proliferation-migration-immune-microenvironment-and-drug-sensitivity/333336.png","ImageObject",300,407,{"name":92,"@type":93},"Ava Thompson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this study regarding KHDRBS1 in HCC?","Question",{"text":112,"@type":113},"To determine whether KHDRBS1 functions as a novel prognostic signaling biomarker influencing HCC cell proliferation, migration, immune microenvironment, and drug sensitivity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study analyze KHDRBS1-related mechanisms?",{"text":117,"@type":113},"It integrated and analyzed multi-omics, multi-cohort data from public databases and validated findings using clinical samples and molecular biology, then leveraged HCC single-cell sequencing to compare KHDRBS1-positive versus negative malignant cells.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the results indicate about KHDRBS1 in tumor progression?",{"text":121,"@type":113},"KHDRBS1 is identified as a tumor-promoting factor, and KHDRBS1 positivity correlates with tumor progression, with clinical significance highlighted for KHDRBS1-positive malignant cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333336,1790196902,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","TYPE Original Research PUBLISHED 10 April 2024  \nDOI 10.3389/fimmu.2024.1393801  \nOPEN ACCESS  \nEDITED BY  \nWenhong Deng,  \nRenmin Hospital of Wuhan University, China  \nREVIEWED BY Jing Zhang,  \nUniversity of South Dakota, United States Chao Li,  \nLMU Munich University Hospital, Germany  \n*CORRESPONDENCE Dongyan Shen  \n [shendongyan@xmu.edu.cn](shendongyan@xmu.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 29 February 2024  \nACCEPTED 27 March 2024  \nPUBLISHED 10 April 2024  \nCITATION  \nFan R, Liu F, Gong Q, Liu D, Tang S and Shen D (2024) KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity.  \nFront. Immunol. 15:1393801 .  \ndoi: 10.3389/fimmu.2024.1393801  \nCOPYRIGHT  \n© 2024 Fan, Liu, Gong, Liu, Tang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nKHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and  \ndrug sensitivity  \nRui Fan 1†, Fahui Liu 1†, Qiming Gong 2,3†, Donghua Liu 1, Shihang Tang 1 and Dongyan Shen 1*  \n1Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China, 2 Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China, 3 Baise Key Laboratory for Metabolic Diseases (Youjiang Medical University for Nationalities), Education Department of Guangxi Zhuang Autonomous Region, Baise, China  \nBackground: Human tumors pose significant challenges, with targeted therapy against specific molecular targets or signaling pathways being a mainstay alongside surgical resection. Previous studies have implicated KHDRBS1 in the oncogenesis of certain human tumors such as colorectal and prostate cancers, underscoring its potential as a therapeutic target. However, the comprehensive expression pattern of KHDRBS1 in hepatocellular carcinoma (HCC) warrants further exploration.  \nMethods: Integrating and analyzing multi-omics, multi-cohort data from public databases, coupled with clinical samples and molecular biology validation, we elucidate the oncogenic role of KHDRBS1 in HCC progression. Additionally, leveraging HCC single-cell sequencing data, we segregate malignant cells into KHDRBS1-positive and negative subsets, uncovering significant differences in their expression profiles and functional roles.  \nResults: Our study identifies KHDRBS1 as a tumor-promoting factor in HCC, with its positivity correlating with tumor progression. Furthermore, we highlight the clinical significance of KHDRBS1-positive malignant cells, aiming to further propel its clinical utility.  \nConclusion: KHDRBS1 plays a key role in HCC development. This study provides crucial insights for further investigation into KHDRBS1 as a therapeutic target in HCC.  \nKEYWORDS  \nHCC, KHDRBS1, immune, migration, multi-omics, biomarker  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nHepatocellular carcinoma (HCC), a highly lethal malignancy worldwide, has long been a focal point in the medical community (1) . Treatment modalities for HCC have evolved from traditional surgical resection, radiotherapy, and chemotherapy to more refined approaches such as molecular targeted therapy and immunotherapy. Molecular targeted agents like sorafenib have become standard therapy for advanced HCC patients, while immunotherapy, particularly immune checkpoint inhibitors like nivolumab, has shown promis","cbCaidGmjsD9mqP8","https://ap.wps.com/l/cbCaidGmjsD9mqP8","pdf",30553531,16,"English","# Introduction\n## Background and rationale\n# Methods\n## Multi-omics integration and validation\n## Single-cell subset analysis\n# Results\n## KHDRBS1 tumor-promoting role\n## Clinical significance of KHDRBS1-positive cells\n# Conclusion","[{\"question\":\"What is the main objective of this study regarding KHDRBS1 in HCC?\",\"answer\":\"To determine whether KHDRBS1 functions as a novel prognostic signaling biomarker influencing HCC cell proliferation, migration, immune microenvironment, and drug sensitivity.\"},{\"question\":\"How did the study analyze KHDRBS1-related mechanisms?\",\"answer\":\"It integrated and analyzed multi-omics, multi-cohort data from public databases and validated findings using clinical samples and molecular biology, then leveraged HCC single-cell sequencing to compare KHDRBS1-positive versus negative malignant cells.\"},{\"question\":\"What do the results indicate about KHDRBS1 in tumor progression?\",\"answer\":\"KHDRBS1 is identified as a tumor-promoting factor, and KHDRBS1 positivity correlates with tumor progression, with clinical significance highlighted for KHDRBS1-positive malignant cells.\"}]","KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity | PDF",1790002031]