[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330549-105":59,"doc-detail-330549-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","key-players-of-immunosuppression-in-epithelial-malignancies-tumor-infiltrating-myeloid-cells-and-t-cells-review","Key players of immunosuppression in epithelial malignancies - Tumor-infiltrating myeloid cells and γδ T cells - Review","","The tumor microenvironment of solid epithelial malignancies drives differentiation of macrophage and gamma delta (γδ) T cell precursors into potent immunosuppressors. Upon tumor bed infiltration, tumor-associated macrophages, precursor monocytic MDSCs (M-MDSCs), and γδ T cells acquire strong suppressive functions that blunt spontaneous anti-cancer immune responses mediated by tumor-infiltrating T cells and B lymphocytes. Both M-MDSCs and γδ T cells correlate with worse prognosis across multiple epithelial cancers. The review synthesizes recent findings on these mechanisms, links them to metastasis, and highlights prospective interventions to restore effective adaptive immunity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/key-players-of-immunosuppression-in-epithelial-malignancies-tumor-infiltrating-myeloid-cells-and-t-cells-review/330549/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/key-players-of-immunosuppression-in-epithelial-malignancies-tumor-infiltrating-myeloid-cells-and-t-cells-review/330549.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does the tumor microenvironment promote immunosuppressive cell differentiation in epithelial malignancies?","Question",{"text":113,"@type":114},"The review explains that the tumor microenvironment of solid tumors drives otherwise non-immunosuppressive macrophages and γδ T cells toward immunosuppressive phenotypes, including enhanced suppressive abilities of myeloid-derived suppressor cells after infiltration into tumor beds.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which immune cells are highlighted as suppressive players in epithelial cancers?",{"text":118,"@type":114},"Tumor-associated macrophages, precursor monocytic MDSCs (M-MDSCs), and γδ T cells are described as key immunosuppressive cells. Their suppressive activities dampen immune responses involving tumor-infiltrating T cells and B lymphocytes.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the clinical significance of M-MDSCs and γδ T cells mentioned in the abstract?",{"text":122,"@type":114},"The abstract states that both M-MDSCs and γδ T cells are associated with worse prognosis across multiple epithelial cancers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330549,1790138728,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","DOI: 10.1002/cnr2.2066  \nREVIE W  \nKey players of immunosuppression in epithelial malignancies: Tumor-infiltrating myeloid cells and γδ T cells  \nBaishali Tamuli 1 | Sakshi Sharma 1 | Meena Patkar 1 | Subir Biswas 1,2   \n1Tumor Immunology and Immunotherapy, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India 2Homi Bhabha National Institute, Mumbai, India  \nCorrespondence  \nSubir Biswas, Tumor Immunology and Immunotherapy, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, Maharashtra 410210, India.  \nEmail: [sbiswas@actrec.gov.in](sbiswas@actrec.gov.in); [subirbiswas.cu@](subirbiswas.cu@)[ ](subirbiswas.cu@)[gmail.com](gmail.com)  \nFunding information  \nDepartment of Biotechnology, Ministry of Science and Technology, India, Grant/Award Number: BT/RLF/Re-entry/48/2021; Capacity Building and Development of Novel Cutting Edge Research Activities, Grant/Award Number: DPR1/3(4)/2021/TMC/R&DII/15063; Animal Imaging at ACTREC, Grant/Award Number: 1/3(6)/2020/TMC/ R&D-II/3805; Basic & Translational Research in Cancer, Grant/Award Number: 1/3  \n(7)/2020/TMC/R&D-II/8823; Start-up Research Grant  \nAbstract  \nBackground: The tumor microenvironment of solid tumors governs the differentiation of otherwise non-immunosuppressive macrophages and gamma delta (γδ) T cells into strong immunosuppressors while promoting suppressive abilities of known immunosuppressors such as myeloid-derived suppressor cells (MDSCs) upon infiltration into the tumor beds.  \nRecent findings: In epithelial malignancies, tumor-associated macrophages (TAMs), precursor monocytic MDSCs (M-MDSCs), and gamma delta (γδ) T cells often acquire strong immunosuppressive abilities that dampen spontaneous immune responses by tumor-infiltrating T cells and B lymphocytes against cancer. Both M-MDSCs and γδ T cells have been associated with worse prognosis for multiple epithelial cancers. Conclusion: Here we discuss recent discoveries on how tumor-associated macrophages and precursor M-MDSCs as well as tumor associated-γδ T cells acquire immunosuppressive abilities in the tumor beds, promote cancer metastasis, and perspectives on how possible novel interventions could restore the effective adaptive immune responses in epithelial cancers.  \nKEYWOR DS  \ngamma delta T cells, immunology, immunotherapy, MDSCs, tumor microenvironment, tumorassociated macrophages  \n1 | INTRODUCTION  \nEpithelial cancer microenvironment is infiltrated with variable numbers of T cells,1–5 B lymphocytes,1–6 Natural Killer (NK) cells,4,5,7 and different myeloid cells that include neutrophils, dendritic cells, monocytes, myeloid-derived suppressor cells (MDSCs) .4,5,8–11 However, the antitumor functions of T cells or antibody production by tumorinfiltrated B lymphocytes are often compromised due to the strong immunosuppressive environment with the tumor beds in the majority of human cancers. Hence, the immunosuppressive cell differentiation  \nBaishali Tamuli and Sakshi Sharma contributed equally to this work.  \nin the tumor microenvironment (TME) from tumor-infiltrated myeloid precursors and γδ T cells has gained immense attention in the field. Myeloid cells which are primarily involved in the host defense mechanism12,13 also contribute to the malignant progression of epithelial cancers when accumulated in the TME.8,14 Among myeloid lineage cells, apart from terminally differentiated dendritic cells and monocytes that differentiate into macrophages in tissues under inflammatory conditions, MDSCs are the major contributor to an immunosuppressive microenvironment.15 Polymorphonuclear type of MDSCs commonly known as PMN-MDSCs, resemble neutrophils in terms of their morphology and phenotypes,9 but they differ in their functions from neutrophils as classically activated neutrophils show  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permi","cbCaiksnEsXO6CLB","https://ap.wps.com/l/cbCaiksnEsXO6CLB","pdf",2281545,15,"English","# Abstract\n## Background and recent findings\n## Conclusion\n# Introduction\n## Tumor microenvironment and immunosuppression\n## Myeloid-derived suppressor cells and macrophage differentiation","[{\"question\":\"How does the tumor microenvironment promote immunosuppressive cell differentiation in epithelial malignancies?\",\"answer\":\"The review explains that the tumor microenvironment of solid tumors drives otherwise non-immunosuppressive macrophages and γδ T cells toward immunosuppressive phenotypes, including enhanced suppressive abilities of myeloid-derived suppressor cells after infiltration into tumor beds.\"},{\"question\":\"Which immune cells are highlighted as suppressive players in epithelial cancers?\",\"answer\":\"Tumor-associated macrophages, precursor monocytic MDSCs (M-MDSCs), and γδ T cells are described as key immunosuppressive cells. Their suppressive activities dampen immune responses involving tumor-infiltrating T cells and B lymphocytes.\"},{\"question\":\"What is the clinical significance of M-MDSCs and γδ T cells mentioned in the abstract?\",\"answer\":\"The abstract states that both M-MDSCs and γδ T cells are associated with worse prognosis across multiple epithelial cancers.\"}]","Key players of immunosuppression in epithelial malignancies - Tumor-infiltrating myeloid cells and γδ T cells - Review | PDF",1789989375,38]