[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-365758-105":59,"doc-detail-365758-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","keratin-80-as-a-diagnostic-biomarker-with-limited-prognostic-value-in-non-small-cell-lung-cancer","Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer","","Investigation of KRT80 (keratin 80) expression in non-small cell lung cancer (NSCLC) assessed its links to clinicopathological factors, prognostic impact, and geographic or histological differences. Using immunohistochemistry across 178 clinical cases and supported by public databases, the study found up-regulation of KRT80 in NSCLC tissues versus paracancer tissue. KRT80 expression varied significantly by region (Xuanwei vs non-Xuanwei) and by subtype (LUAD vs LUSC). Despite no direct significant correlation with prognosis, KRT80 distinguished cancer from paracancer tissue, supporting diagnostic biomarker potential.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/keratin-80-as-a-diagnostic-biomarker-with-limited-prognostic-value-in-non-small-cell-lung-cancer/365758/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/keratin-80-as-a-diagnostic-biomarker-with-limited-prognostic-value-in-non-small-cell-lung-cancer/365758.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study designed to evaluate regarding KRT80 in NSCLC?","Question",{"text":112,"@type":113},"The study evaluated KRT80 expression in NSCLC patients and its association with clinicopathological factors, prognosis, and differences between Xuanwei vs non-Xuanwei areas and LUAD vs LUSC subtypes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was KRT80 expression measured in the research?",{"text":117,"@type":113},"KRT80 expression was examined using immunohistochemical methods, with support from public databases.",{"name":119,"@type":110,"acceptedAnswer":120},"Does KRT80 expression have prognostic value for NSCLC patients?",{"text":121,"@type":113},"KRT80 expression showed no direct significant correlation with NSCLC patient prognosis, but it had good ability to distinguish cancerous from paracancer tissue.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},365758,1790207451,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nKeratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer  \nYing Zeng1,5, Hongting Jiang1,5, Yuting Xia2,3, Zhonglian Wang1, Fei Zhang1, Cha Luo1, Qing Ye1, Wei Jian1, Jing Zhang1, Qingmei Yang4 & Qiaofen Fu1􀀍  \nTo investigate the expression of KRT80 in non-small cell lung cancer (NSCLC) patients and its relationship with clinicopathological factors, prognosis, as well as the differences in KRT80 expression between Xuanwei area and Non-xuanwei area, lung adenocarcinoma and lung squamous cell carcinoma. Based on 178 clinical cases, immunohistochemical methods combined with public databases were used to examine the expression of KRT80 in NSCLC patients and analyze its correlation with various clinicopathological factors and prognosis. The study confirmed the up-regulation of KRT80 expression in NSCLC cancer tissues. Significant regional specific and histological subtype differences in KRT80 expression were revealed. Although the expression level of KRT80 has no direct significant correlation with the prognosis of NSCLC patients, it has a good ability to distinguish cancerous tissue from paracancer tissue. KRT80 can be used as a diagnostic biomarker for NSCLC patients, but its specific mechanism and clinical application value still need to be further explored.  \nKeywords KRT80, NSCLC, Xuanwei lung cancer, Biomarkers  \nGlobal Cancer Statistics 2022 showed that lung cancer is not only the most common type of cancer worldwide, accounting for 12.4% of all cancer cases, but also the leading cause of cancer deaths, accounting for 18.7% of cancer-related deaths worldwide1. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all lung cancer cases with a survival rate of less than 15%, with lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) being the most common NSCLC subtypes2. Lung squamous cell carcinoma tends to occur in men and is strongly associated with smoking, while LUAD usually occurs in women who do not smoke3. Remarkably, the Xuanwei region of China’s Yunnan Province has one of the highest rates of lung cancer in the world and often exhibits familial clustering4. Xuanwei Lung cancer (XWLC) refers to a lung cancer in Xuanwei City and Fuyuan County, Yunnan Province, China, with high morbidity and mortality due to the extensive use of local bituminous coal, characterized by a younger age of onset, significant gender differences, and a mortality rate much higher than the national average5. Lung cancer in this region is dominated by adenocarcinoma, and the risk is higher among female residents6. Studies have shown that the high incidence of lung cancer is not significantly related to gender or smoking habits, but is mainly closely related to the behavior of burning bituminous coal in the family7. While immunotherapy and targeted therapy have significantly improved the efficacy of NSCLC treatment over the past 20 years, the majority of NSCLC patients develop resistance to targeted drugs and disease progression at advanced stages8. Therefore, the search for new diagnostic and prognostic biomarkers for NSCLC remains critical.  \nKeratin, also known as cytokeratin, is an intermediate filament (IF) forming protein of epithelial cells and is expressed in both normal and malignant epithelial cells9. These small molecular weight structural proteins (molecular weight from 40 to 76 kDa) are able to interact with a variety of regulatory proteins to initiate a signaling cascade10. As a typical marker of epithelial cells, keratin is widely expressed in a variety of cancers and plays an important role in regulating cell migration, invasion and epithelial-mesenchymal transition (EMT)11. The Keratin 80 (KRT80) gene, located on chromosome 12q13, encodes a protein of 452 amino acids that promotes the formation of intermediate filaments (IF) heterodimers, struc","cbCaiuuKblIKyfz4","https://ap.wps.com/l/cbCaiuuKblIKyfz4","pdf",3844657,12,"English","# Study objectives and rationale\n## Background on NSCLC burden and need for biomarkers\n## Keratin biology and rationale for KRT80","[{\"question\":\"What was the study designed to evaluate regarding KRT80 in NSCLC?\",\"answer\":\"The study evaluated KRT80 expression in NSCLC patients and its association with clinicopathological factors, prognosis, and differences between Xuanwei vs non-Xuanwei areas and LUAD vs LUSC subtypes.\"},{\"question\":\"How was KRT80 expression measured in the research?\",\"answer\":\"KRT80 expression was examined using immunohistochemical methods, with support from public databases.\"},{\"question\":\"Does KRT80 expression have prognostic value for NSCLC patients?\",\"answer\":\"KRT80 expression showed no direct significant correlation with NSCLC patient prognosis, but it had good ability to distinguish cancerous from paracancer tissue.\"}]","Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer | PDF",1790162164]