[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378404-105":59,"doc-detail-378404-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","journey-through-words-exploring-esophageal-cancer-in-literature-review","Journey Through Words: Exploring Esophageal Cancer in Literature - Review","","Esophageal cancer is a major global health threat marked by aggressive progression and high mortality, with an uneven burden on males. It ranks among the leading causes of cancer-related deaths worldwide, and projections suggest its prevalence may rise by about 140% by 2025. The disease mainly includes two subtypes, esophageal squamous cell carcinoma and adenocarcinoma, each with distinct features. This review examines risk factors, anatomy, presentation, diagnosis, staging, prognosis, treatment, recurrence, and emerging therapies, and also covers primary, secondary, and tertiary prevention and early detection strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/journey-through-words-exploring-esophageal-cancer-in-literature-review/378404/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/journey-through-words-exploring-esophageal-cancer-in-literature-review/378404.png","ImageObject",300,407,{"name":92,"@type":93},"Elsa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the main subtypes of esophageal cancer discussed in the review?","Question",{"text":112,"@type":113},"The review identifies two primary subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), each with distinct epidemiological and biological characteristics.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which topics does the review cover regarding esophageal cancer management?",{"text":117,"@type":113},"It covers risk factors, anatomy, clinical presentation, diagnosis, staging, prognosis, treatment modalities, recurrence, and advancements including emerging therapies.",{"name":119,"@type":110,"acceptedAnswer":120},"What prevention and early detection strategies are included?",{"text":121,"@type":113},"The review discusses primary, secondary, and tertiary prevention approaches, emphasizing preventive measures and early detection strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378404,1790479938,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137455077381,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Open Access Review  \nArticle DOI: 10.7759/cureus.48411  \nReview began 10/20/2023  \nReview ended 11/04/2023  \nPublished 11/06/2023  \n© Copyright 2023  \nShahid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nJourney Through Words: Exploring Esophageal Cancer in Literature  \nM Hasaan Shahid 1 , Reda H. Mithany 2 , Samana Aslam 3 , Nesma Daniel 4 , Farid Gerges 5 , Muhammad Umar Gill 6 , Andrew Wanees 7 , Shenouda Abdallah 8 , Mark Abdelmaseeh 9 , Abdul Hannan 1  \n1. Surgery, Glangwili General Hospital, Carmarthen, GBR 2. Laparoscopic Colorectal Surgery, Kingston Hospital National Health Service (NHS) Foundation Trust, Kingston, GBR 3. General Surgery, Lahore General Hospital, Lahore, PAK 4. Medical Laboratory Science, Ain Shams University, Cairo, EGY 5. General and Emergency Surgery, Kingston Hospital National Health Service (NHS) Foundation Trust, Kingston, GBR 6. Accident and Emergency, King 's College Hospital National Health Service (NHS) Foundation Trust, London, GBR 7. General Surgery, Dar El-Salam General Hospital, Cairo, EGY 8. Surgery, Jaber Al-Ahmad Hospital, Kuwait City, KWT 9. General Surgery, Faculty of Medicine, Assuit University, Assuit, EGY  \nCorresponding author: Reda H. Mithany, [reda7arby@gmail.com](reda7arby@gmail.com)  \nAbstract  \nEsophageal cancer is a significant global health challenge, characterized by its aggressive nature and high mortality rates. The disease disproportionately affects males and ranks among the leading causes of cancerrelated deaths worldwide. Alarming projections indicate that the prevalence of esophageal cancer is expected to surge by approximately 140% by the year 2025. This trend starkly contrasts with the anticipated decline in incidence observed for many other types of cancers. The cancer manifests primarily in two major subtypes: esophageal squamous cell carcinoma and adenocarcinoma, each with distinct epidemiological and biological characteristics. This review provides an in-depth exploration of the risk factors, anatomy, clinical presentation, diagnosis, staging, prognosis, treatment modalities, recurrence, advancements, and emerging therapies in esophageal cancer. Additionally, preventive and early detection strategies are discussed, focusing on primary, secondary, and tertiary prevention approaches. A comprehensive understanding of esophageal cancer is vital for formulating effective management strategies and improving patient outcomes.  \nCategories: Gastroenterology, General Surgery  \nKeywords: emerging therapies, advancements, recurrence, treatment modalities, staging, diagnosis, risk factors, adenocarcinoma, squamous cell carcinoma, esophageal cancer  \nIntroduction And Background  \nEsophageal cancer represents a significant health concern globally, particularly due to its aggressive nature and substantial mortality rates. It is a malignancy that disproportionately affects males and stands as a prominent contributor to cancer-related fatalities on a global scale. In the year 2005 alone, esophageal cancer accounted for more than 400,000 deaths worldwide, positioning it as the eighth most prevalent cancer and the sixth leading cause of cancer-related deaths internationally. Notably, a vast majority of esophageal cancer cases and related deaths, exceeding 80%, were concentrated in developing nations [1] . Furthermore, disconcerting trends portend a projected escalation in the prevalence of esophageal cancer by approximately 140% by the year 2025. This stands in stark contrast to the expected decline in incidence for numerous other types of cancers [2] .  \nEsophageal cancer manifests primarily in two major subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) . These subtypes possess distinct epidemiological and biological characteristi","cbCaii0Pq8sXIIDi","https://ap.wps.com/l/cbCaii0Pq8sXIIDi","pdf",363062,"English","# Abstract\n# Introduction And Background\n# Review\n## Anatomy of the esophagus\n## Histological analysis\n## How to cite this article","[{\"question\":\"What are the main subtypes of esophageal cancer discussed in the review?\",\"answer\":\"The review identifies two primary subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), each with distinct epidemiological and biological characteristics.\"},{\"question\":\"Which topics does the review cover regarding esophageal cancer management?\",\"answer\":\"It covers risk factors, anatomy, clinical presentation, diagnosis, staging, prognosis, treatment modalities, recurrence, and advancements including emerging therapies.\"},{\"question\":\"What prevention and early detection strategies are included?\",\"answer\":\"The review discusses primary, secondary, and tertiary prevention approaches, emphasizing preventive measures and early detection strategies.\"}]","Journey Through Words: Exploring Esophageal Cancer in Literature - Review | PDF",1790229899,25]