[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-436010-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-436010-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","j-chin-medassoc-highlights","J Chin MedAssoc Highlights","","Highlights summarize five peer-reviewed biomedical research findings across oncology, otolaryngology, cardiology, ophthalmology, and infectious disease risk. Key results include PSMA PET–guided salvage radiotherapy improving failure-free survival with mild toxicity, a simplified audiogram model enhancing recovery prediction, cardiac MRI markers for pulmonary hypertension prognosis, PM2.5 exposure linking to retinal pigment epithelium pathway activation via TGFβ/ANGPTL4, and vitamin D deficiency associated with higher COVID-19 mortality in older adults.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/j-chin-medassoc-highlights/436010/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/j-chin-medassoc-highlights/436010.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the PSMA PET–guided salvage radiotherapy highlight report for recurrent prostate cancer?","Question",{"text":63,"@type":64},"It reports that combining salvage radiotherapy with a PSMA-directed focal boost improves failure-free survival compared with androgen deprivation therapy alone, with predominantly mild adverse effects.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does the audiogram model change prognosis prediction in sudden hearing loss?",{"text":68,"@type":64},"It introduces a three-category classification using 4 kHz threshold data that improves prognostic accuracy versus the conventional seven-category approach, with different recovery rates by pattern group.",{"name":70,"@type":61,"acceptedAnswer":71},"What mechanisms and targets are suggested for PM2.5-related retinal disease?",{"text":72,"@type":64},"The highlight links PM2.5 exposure to gene expression changes in retinal pigment epithelium cells, activating TGFβ signaling and upregulating ANGPTL4, and notes that inhibiting TGFβ prevents ANGPTL4 induction.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},436010,1790719001,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","J Chin MedAssoc  \nHigHligHts  \nHighlights  \nJong-Ling Fuh  \nDeputy Editor-in-Chief  \n1. PSMA PET–Guided salvage radiotherapy in prostate cancer This study demonstrates that salvage radiotherapy combined with a Prostate-specific membrane antigen (PSMA)-directed focal boost is an effective intervention for recurrent prostate cancer, offering favorable biochemical control with minimal toxicity. In a cohort of 56 patients, PSMA Positron emission tomography (PET)–guided radiotherapy was associated with a significantly longer failure-free survival (42.1 months) compared to androgen deprivation therapy alone (23.4 months, p \u003C 0.001), while adverse effects were predominantly mild. These results support the use of PSMA PET–guided radiotherapy as a targeted, individualized treatment strategy with potential to influence future clinical standards.1  \n2. A novel audiogram model for sudden hearing loss The prediction of recovery outcomes in cases of sudden sensorineural hearing loss remains complex. This study presentsa three-category audiogram classification, utilizing 4 kHz threshold data, which demonstrates improved prognostic accuracy compared to the conventional seven-category approach. In a cohort of 965 patients (mean age 50.8 years;  \n51.5% male), those exhibiting the “4 kHz best” audiogram pattern achieved a 49% recovery rate, whereas the “intermediate” and “4 kHz worst” groups demonstrated recovery rates of 36% and 20%, respectively (p \u003C 0.001) . Complete recovery was observed in 21.1% of participants. The streamlined model is practical for clinical application and enhances prognostic clarity for otolaryngology practice and patient counselling.2  \n3. Cardiac MRI for prognosis in pulmonary hypertension A longitudinal investigation involving 36 patients diagnosed with pulmonary hypertension demonstrated that cardiac magnetic resonance imaging (MRI) is an effective modality for predicting adverse clinical outcomes. Increased right ventricular volume and declining strain correlated with higher rates of hospitalization or mortality, whereas maintained left ventricular volume and improved ejection fraction were indicative of a favorable prognosis. The findings underscore the utility and reliability of cardiac MRI for early risk stratification in this population, with performance surpassing conventional indicators such as World Health Organization (WHO) classification and N terminal pro B type natriuretic peptide (NT-proBNP) levels.3  \nJournal of Chinese Medical Association. (2025): 809.  \nReceived September 29, 2025; accepted September 30, 2025. doi: 10. 1097/JCMA.0000000000001303  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \n4. Air pollution and retinal disease mechanisms  \nThis study examines the impact of particulate matter (PM)2.5 air pollution on retinal pigment epithelium (RPE) cells through next-generation sequencing and functional assays. The findings demonstrate that PM2.5 exposure significantly influences gene expression, notably activating the transforming growth factor beta (TGFβ) signaling pathway and upregulating angiopoietin like 4 (ANGPTL4), which promotes RPE cell migration. Pathway analysis reveals modifications in focal adhesion, cytoskeletal organization, and extracellular matrix interactions. Furthermore, inhibition of TGFβ prevented ANGPTL4 induction, substantiating its regulatory role. Collectively, these results establish a connection between PM2.5 and retinal disease mechanisms, such as age-related macular degeneration, and identify ANGPTL4 and TGFβ as promising therapeutic targets.4  \n5. Vitamin D deficiency and COVID-19 mortality  \nThis study investigates the association between serum vita-min D levels and Coronavirus Disease 2019 (COVID-19) associated mortality. Findings indicate that vitamin ","cbCaiibiLFb9nCci","https://ap.wps.com/l/cbCaiibiLFb9nCci","pdf",314650,"English","# Highlights\n## PSMA PET–Guided salvage radiotherapy in prostate cancer\n## A novel audiogram model for sudden hearing loss\n## Cardiac MRI for prognosis in pulmonary hypertension\n## Air pollution and retinal disease mechanisms\n## Vitamin D deficiency and COVID-19 mortality","[{\"question\":\"What does the PSMA PET–guided salvage radiotherapy highlight report for recurrent prostate cancer?\",\"answer\":\"It reports that combining salvage radiotherapy with a PSMA-directed focal boost improves failure-free survival compared with androgen deprivation therapy alone, with predominantly mild adverse effects.\"},{\"question\":\"How does the audiogram model change prognosis prediction in sudden hearing loss?\",\"answer\":\"It introduces a three-category classification using 4 kHz threshold data that improves prognostic accuracy versus the conventional seven-category approach, with different recovery rates by pattern group.\"},{\"question\":\"What mechanisms and targets are suggested for PM2.5-related retinal disease?\",\"answer\":\"The highlight links PM2.5 exposure to gene expression changes in retinal pigment epithelium cells, activating TGFβ signaling and upregulating ANGPTL4, and notes that inhibiting TGFβ prevents ANGPTL4 induction.\"}]","J Chin MedAssoc Highlights | PDF",1790676406]