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It also reports air-transferred stroke thrombectomy feasibility, links retinal vessel density to preclinical CADASIL cognition, defines Taiwanese MoCA normative values with an updated cutoff, and presents comprehensive genomic profiling results for Taiwanese triple-negative breast cancer.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/j-chin-medassoc-highlights-highlights/433595/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/j-chin-medassoc-highlights-highlights/433595.png","ImageObject",300,407,{"name":42,"@type":43},"Patrick","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the highlights section say about GLP-1–based therapy in CKM syndrome?","Question",{"text":63,"@type":64},"It emphasizes that incretin-based therapies, especially GLP-1 receptor agonists such as semaglutide, provide benefits beyond blood sugar control, including reductions in major cardiovascular events and improvements in kidney health, framed within the CKM syndrome model.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does the study describe air transport for endovascular thrombectomy in remote areas?",{"text":68,"@type":64},"Patients transferred by air from Kinmen to Taipei for EVT showed clinical outcomes comparable to patients treated directly at the destination center, despite longer onset-to-puncture times, with factors like younger age and lower baseline NIHSS linked to better outcomes.",{"name":70,"@type":61,"acceptedAnswer":71},"What are the main findings of the Taiwanese MoCA normative study?",{"text":72,"@type":64},"Using data from over 2,300 community adults aged 50–90, the study provides regression-based norms adjusted for age, sex, and education, identifies demographic influences on performance, and proposes a Taiwanese-tailored cutoff for early cognitive impairment.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},433595,1790717380,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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Incretin-based therapy for cardiovascular-kidney-metabolic health  \nThis leading-edge review explores how incretin-based therapies, especially GLP-1 receptor agonists like semaglutide, are revolutionizing the treatment of type 2 diabetes, obesity, and related organ damage. While initially valued for blood sugar control, these agents are now recognized for broader benefits, including significant reductions in major cardiovascular events, improved kidney health, and relief from heart failure symptoms. The article introduces the new cardiovascular-kidney-metabolic (CKM) syndrome framework, emphasizing the deep connections between diabetes, chronic kidney disease, and cardiovascular conditions. Supported by evidence from major clinical trials, the review highlights GLP-1 as a groundbreaking therapy with multi-organ benefits for both diabetic and non-diabetic patients. Specifically, GLP-1 receptor agonists have been shown to cut major adverse cardiovascular events by 14% and all-cause mortality by 18% in type 2 diabetes patients. Semaglutide, in particular, significantly reduces major renal events by 24% and can lead to a 12.4% reduction in body weight in obese individuals without diabetes. The review champions a move away from single-disease approaches towards integrated metabolic care, positioning incretins as vital modulators in comprehensive chronic disease prevention and treatment, beyond just glucose management.1  \n2. Air-transferred stroke thrombectomy between Kinmen and Taipei  \nThis study demonstrates the successful use of air transport to provide acute stroke care from remote areas, showing that acute ischemic stroke patients flown from Kinmen Hospital to Taipei Veterans General Hospital (TVGH) for endovascular thrombectomy (EVT) achieved clinical outcomes comparable to those treated directly at TVGH. Even with longer onset-to-puncture times, the air-transferred group had similar 90-day functional outcomes and reperfusion rates as patients presenting directly, highlighting that interfacility air transfer for EVT is a practical approach for rapid stroke intervention in geographically isolated settings. Key factors linked to better functional recovery included younger age, shorter door-to-puncture time, and lower initial National Institutes of Health Stroke Scale (NIHSS) scores.2  \n3. Retinal vessel density and preclinical CADASIL cognition  \nThis study unveils a novel link between ophthalmologic imaging and cognitive neurology, showing that increased parafoveal vessel density in the superficial retinal plexus correlates significantly  \nJournal of Chinese Medical Association. (2025) 88: 579-580.  \nReceived July 9, 2025; accepted July 10, 2025. doi: 10. 1097/JCMA.0000000000001267  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nwith lower cognitive performance in asymptomatic carriers of the NOTCH3 p.R544C mutation. These findings suggest that retinal OCT angiography could serve as an early, non-invasive biomarker for cognitive impairment in cerebral small vessel disease, enabling earlier diagnosis and preventive intervention in CADASIL even before overt stroke or dementia. The research aimed to clarify the relationship between retinal microcirculation, brain white matter hyperintensities (WMH), and cognitive decline in individuals at the preclinical stage of CADASIL. Even with subtle MRI changes, higher macular vessel density was associated with poorer memory and attention scores, possibly indicating a compensatory blood flow increase in response to early microvascular damage, which may signal an early maladaptive process in the capillary plexus. Thus, a simple eye scan could offer crucial insights into early brain changes i","cbCaiscTrCZb1y1m","https://ap.wps.com/l/cbCaiscTrCZb1y1m","pdf",284363,"English","# HIGHLIGHTS\n## Incretin-based therapy for cardiovascular-kidney-metabolic health\n## Air-transferred stroke thrombectomy between Kinmen and Taipei\n## Retinal vessel density and preclinical CADASIL cognition\n## Normative study of the Taiwanese version of the MoCA\n## Comprehensive genomic profiling of triple-negative breast cancer","[{\"question\":\"What does the highlights section say about GLP-1–based therapy in CKM syndrome?\",\"answer\":\"It emphasizes that incretin-based therapies, especially GLP-1 receptor agonists such as semaglutide, provide benefits beyond blood sugar control, including reductions in major cardiovascular events and improvements in kidney health, framed within the CKM syndrome model.\"},{\"question\":\"How does the study describe air transport for endovascular thrombectomy in remote areas?\",\"answer\":\"Patients transferred by air from Kinmen to Taipei for EVT showed clinical outcomes comparable to patients treated directly at the destination center, despite longer onset-to-puncture times, with factors like younger age and lower baseline NIHSS linked to better outcomes.\"},{\"question\":\"What are the main findings of the Taiwanese MoCA normative study?\",\"answer\":\"Using data from over 2,300 community adults aged 50–90, the study provides regression-based norms adjusted for age, sex, and education, identifies demographic influences on performance, and proposes a Taiwanese-tailored cutoff for early cognitive impairment.\"}]","J Chin MedAssoc - HIGHLIGHTS - Highlights | PDF",1790664745]