[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436360-105":59,"doc-detail-436360-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","j-chin-medassoc-highlights-436360","J Chin MedAssoc - Highlights","","Highlights from the Journal of the Chinese Medical Association (2025) present five clinical research findings. Results include PIVKA-II as an independent prognostic biomarker for AFP-negative hepatocellular carcinoma, and improved intracranial control when osimertinib is combined with radiotherapy in EGFR-mutant NSCLC, with neurologic benefit despite no OS gain. A randomized trial supports Ban-Xia-Hou-Pu-Tang as a safe adjunct for globus sensation, while a long-term retrospective study links delayed care and fracture comminution to open surgery needs in ulnar-sided CMC injuries. Endovascular sequencing shows feasibility and acceptable outcomes for dual aortic pathology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/j-chin-medassoc-highlights-436360/436360/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/j-chin-medassoc-highlights-436360/436360.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What prognostic role does PIVKA-II play in hepatocellular carcinoma patients with normal AFP?","Question",{"text":112,"@type":113},"Elevated PIVKA-II levels were significantly associated with larger, more aggressive tumors and poorer overall survival. Multivariate analysis confirmed PIVKA-II as an independent predictor of overall survival.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Does adding intracranial radiotherapy to osimertinib improve outcomes in EGFR-mutant NSCLC?",{"text":117,"@type":113},"The combined approach substantially improved local and distant intracranial tumor control, with a higher 3-year control rate than TKI alone. Overall survival was not prolonged, and systemic toxicity did not increase.",{"name":119,"@type":110,"acceptedAnswer":120},"How effective and safe is Ban-Xia-Hou-Pu-Tang when combined with Western therapy for globus sensation?",{"text":121,"@type":113},"In a randomized, placebo-controlled trial, the combination group showed greater improvements in reflux-related and symptom severity measures versus control. The regimen was well tolerated with no hepatic or renal toxicity reported.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436360,1790717381,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nHigHligHts  \nHighlights  \nJong-Ling Fuh  \nDeputy Editor-in-Chief  \n1. PIVKA-II outperforms AFP as a prognostic biomarker in hepatocellular carcinoma. In hepatocellular carcinoma (HCC) patients with normal serum alpha-fetoprotein (AFP) levels (\u003C20 ng/mL), there remains a critical need for reliable prognostic biomarkers. This retrospective study evaluated  \n330 treatment-naïve patients within this subgroup to assess the prognostic significance of Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) . The analysis revealed that elevated PIVKA-II levels (>100 mAU/mL) were significantly associated with larger, more aggressive tumors and markedly poorer overall survival (OS). Importantly, multivariate analysis confirmed PIVKA-II as an independent predictor of OS, highlighting its potential utility in risk stratification and clinical decision-making. These findings support the role of PIVKA-II as a valuable prognostic biomarker for AFPnegative HCC populations.1  \n2. Synergistic intracranial control: Osimertinib combined with radiotherapy in EGFR-mutant NSCLC. This retrospective study evaluated the therapeutic impact of combining intracranial radiotherapy (RT) with a blood–brain barrier–penetrant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), such as osimertinib, in Asian patients with EGFR-mutated lung adenocarcinoma and brain metastases. The combined approach significantly enhanced both local and distant intracranial tumor control, with the RT-plus-TKI group achieving a markedly higher 3-year control rate (77%) compared with the TKI-alone group (23%) . Although overall survival was not prolonged, the addition of RT conferred substantial intracranial benefits without increasing systemic toxicity. These findings underscore the value of multimodal precision therapy and support integrating intracranial radiotherapy into osimertinib-based regimens to optimize neurological outcomes in advanced NSCLC.2  \n3. Traditional meets modern: Ban-Xia-Hou-Pu-Tang Enhances Western Therapy for Globus Sensation. This randomized, placebo-controlled trial investigated the therapeutic potential of combining Ban-Xia-Hou-Pu-Tang (BXHPT,半夏厚朴湯), a traditional Chinese medicine formula, with standard Western medication for patients experiencing globus sensation—a common, non-painful throat discomfort that currently lacks standardized treatment. Participants were randomly assigned to receive either BXHPT plus Western therapy or Western therapy with placebo. The combined treatment group demonstrated significantly greater improvements in Reflux Finding Scores (RFS), laryngoscopic inflammation, and symptom severity (as measured by the Glasgow Edinburgh Throat Score and the Reflux Symptom Index) compared with the control group. Importantly, the regimen  \nJournal of Chinese Medical Association. (2025) 88: 895-896.  \nReceived November 3, 2025; accepted November 4, 2025. doi: 10. 1097/JCMA.0000000000001315  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nwas well tolerated, with no hepatic or renal toxicity observed. These findings support BXHPT as a safe and effective adjunctive therapy, offering a promising integrative approach that bridges traditional Chinese medicine and evidence-based clinical practice in the management of globus pharyngeus.3  \n4. Timing and Fracture Pattern Predict Open Surgery in UlnarSided CMC Joint Injuries. This 13-year retrospective study examined ulnar-sided carpometacarpal joint (CMCJ) fracturedislocations—a rare and frequently overlooked hand injury that often requires surgical intervention. Analyzing cases treated between 2009 and 2022, the study identified surgical delay (≥2 weeks) and intra-articular comminution as key factors necessitating open reduction rather than c","cbCaiu02qAwtxftx","https://ap.wps.com/l/cbCaiu02qAwtxftx","pdf",291607,"English","# Highlights\n## PIVKA-II in AFP-negative hepatocellular carcinoma\n## Osimertinib plus radiotherapy for intracranial control in EGFR-mutant NSCLC\n## Ban-Xia-Hou-Pu-Tang adjunct therapy for globus sensation\n## Timing and fracture pattern in ulnar-sided CMC joint injuries\n## Endovascular strategy for dual aortic pathology","[{\"question\":\"What prognostic role does PIVKA-II play in hepatocellular carcinoma patients with normal AFP?\",\"answer\":\"Elevated PIVKA-II levels were significantly associated with larger, more aggressive tumors and poorer overall survival. Multivariate analysis confirmed PIVKA-II as an independent predictor of overall survival.\"},{\"question\":\"Does adding intracranial radiotherapy to osimertinib improve outcomes in EGFR-mutant NSCLC?\",\"answer\":\"The combined approach substantially improved local and distant intracranial tumor control, with a higher 3-year control rate than TKI alone. Overall survival was not prolonged, and systemic toxicity did not increase.\"},{\"question\":\"How effective and safe is Ban-Xia-Hou-Pu-Tang when combined with Western therapy for globus sensation?\",\"answer\":\"In a randomized, placebo-controlled trial, the combination group showed greater improvements in reflux-related and symptom severity measures versus control. The regimen was well tolerated with no hepatic or renal toxicity reported.\"}]","J Chin MedAssoc - Highlights | PDF",1790677725]