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Based on this, a mitochondrial glycolysis regulatory network was constructed to evaluate its impact on mitochondrial homeostasis and the malignant features of ovarian cancer cells. Results show increased ITGB2 and associated PI3K-AKT-mTOR signaling in ovarian cancer.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/itgb2-fosters-the-cancerous-characteristics-of-ovarian-cancer-cells-through-its-role-in-mitochondrial-glycolysis-transformation/327060/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/itgb2-fosters-the-cancerous-characteristics-of-ovarian-cancer-cells-through-its-role-in-mitochondrial-glycolysis-transformation/327060.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does ITGB2 play in ovarian cancer cells according to the paper?","Question",{"text":113,"@type":114},"ITGB2 is proposed to foster cancerous characteristics by promoting mitochondrial glycolysis transformation and supporting tumor cell energy supply.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which signaling pathway is associated with ITGB2 in ovarian cancer?",{"text":118,"@type":114},"The paper links ITGB2 activity to the PI3K-AKT-mTOR signaling route, suggesting that ITGB2 may control mTOR expression through PI3K-AKT.",{"name":120,"@type":111,"acceptedAnswer":121},"How does mitochondrial glycolysis transformation relate to mitophagy and mitochondrial stability?",{"text":122,"@type":114},"The study suggests the PI3K-AKT-mTOR route could inhibit mitophagy, maintain mitochondrial stability, and thereby enhance malignant phenotypes in ovarian cancer cells.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},327060,1791032276,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 3  \nResearch Paper  \nITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation  \nGuo-Wei Li1, Yan-Ping Jin2, Jian-Ping Qiu3, Xiu-Fang Lu3  \n1 Department of Rehabilitation Science, Nanjing Normal University of Special Education, Nanjing, Jiangsu 210000, China  \n2 Department of Obstetrics and Gynecology, Zhongda Hospital Jiangbei Branch, School of Medicine, Southeast University, Nanjing, Jiangsu 210000, China  \n3 Department of Obstetrics and Gynecology, Suzhou Municipal Hospital North, Suzhou, Jiangsu 215000, China  \nCorrespondence to: Jin Yan-Ping; email: [ruoyao5544@163.com](ruoyao5544@163.com), [https://orcid.org/0000-0003-1905-2540](https://orcid.org/0000-0003-1905-2540)[ ](https://orcid.org/0000-0003-1905-2540)[Keywords:](Keywords: glycolysis)[ glycolysis](Keywords: glycolysis), mitophagy, malignant phenotypes, ovarian cancer  \nReceived: September 29, 2023 Accepted: December 27, 2023 Published: February 11, 2024  \nCopyright: © 2024 Guo-Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nRelated studies have shown that ITGB2 mediates mitochondrial glycolytic transformation in cancer-associated fibroblasts and participates in tumor occurrence, metastasis and invasion of cancer cells. Based on these studies, we tried to construct a mitochondrial glycolysis regulatory network and explored its effect on mitochondrial homeostasis and ovarian cancer cells’ cancerous characteristics. Our research revealed a distinct increase in the expression of ITGB2 and associated signaling pathway elements (PI3K-AKT-mTOR) in cases of ovarian cancer. ITGB2 might control mTOR expression via the PI3K-AKT pathway, thus promote mitochondrial glycolysis transformation and cell energy supply in ovarian cancer. This pathway could also inhibit mitophagy, maintain mitochondrial stability, and enhance the cancerous characteristics in case of ovarian cancer cells by mediating mitochondrial glycolytic transformation. Thus, we concluded that ITGB2-associated signaling route (PI3K-AKT-mTOR) may contribute to the progression of cancerous traits in ovarian cancer via mediating mitochondrial glycolytic transformation.  \nINTRODUCTION  \nIn 2020, there are almost 22,000 new ovarian cancer patients in the USA, the number of deaths has nearly reached 14000. The 5-year survival percentage for ovarian cancer patients in China stands at 39.1%, while nearly 70% of patients will suffer recurrence within 1–2 years or even experience multiple recurrence. At the same time, the recurrence cycle may be shortened after each treatment with drug resistance [1, 2] .  \nOvarian cancer is described as a \"silent killer\" because of its high invasiveness and absence of distinct symptoms during its initial phase. The primary therapeutic approach for ovarian cancer cases involves a combination of  \nsurgery and chemotherapy. In recent years, due to continuous advances in treatment combined with individualized chemotherapy, the 5-year survival rate has significantly improved. However, with the emergence of platinum-and paclitaxel-resistant cases, the improvements in survival rate have slowed. Chemotherapy resistance and tumor recurrence are very common in late-stage cases. Currently, numerous academics hold the view that the drug resistance mechanism of ovarian cancer cells is involved in drug transport and metabolism, DNA damage repair, cell apoptosis, tumor autophagy and metabolic recombination [3] .  \nAerobic glycolysis (the Warburg effect) is an important metabolic pathway that maintains the malignant  \nphenotype of tumor cells. It not only provides energy for its proliferation but also provides large numbers of intermediate products for the ","cbCaiuCFv8X1qfOA","https://ap.wps.com/l/cbCaiuCFv8X1qfOA","pdf",1781081,14,"English","# Abstract\n# Introduction\n# Materials and Methods","[{\"question\":\"What role does ITGB2 play in ovarian cancer cells according to the paper?\",\"answer\":\"ITGB2 is proposed to foster cancerous characteristics by promoting mitochondrial glycolysis transformation and supporting tumor cell energy supply.\"},{\"question\":\"Which signaling pathway is associated with ITGB2 in ovarian cancer?\",\"answer\":\"The paper links ITGB2 activity to the PI3K-AKT-mTOR signaling route, suggesting that ITGB2 may control mTOR expression through PI3K-AKT.\"},{\"question\":\"How does mitochondrial glycolysis transformation relate to mitophagy and mitochondrial stability?\",\"answer\":\"The study suggests the PI3K-AKT-mTOR route could inhibit mitophagy, maintain mitochondrial stability, and thereby enhance malignant phenotypes in ovarian cancer cells.\"}]","ITGB2 fosters the cancerous characteristics of ovarian cancer cells through its role in mitochondrial glycolysis transformation | PDF",1789976141,35]