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A female neonate delivered at 32 weeks after progressive isolated fetal ascites developed generalized maternal edema and rapid weight gain consistent with mirror syndrome without hypertension or proteinuria. Extensive maternal and postnatal evaluations excluded infectious, hematologic, metabolic, endocrine, and structural causes; whole-exome sequencing found no genetic etiology. The infant received brief ventilatory support and therapeutic paracentesis with rapid improvement and sustained resolution.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/isolated-transient-neonatal-ascites-in-a-preterm-infant-born-to-a-mother-with-mirror-syndrome-a-case-report/407063/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/isolated-transient-neonatal-ascites-in-a-preterm-infant-born-to-a-mother-with-mirror-syndrome-a-case-report/407063.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What clinical scenario does the case describe?","Question",{"text":113,"@type":114},"The case describes isolated transient neonatal ascites in a preterm infant born to a mother with mirror syndrome, a rare maternal complication.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the underlying cause evaluated?",{"text":118,"@type":114},"Maternal evaluation included TORCH screening and karyotyping; postnatal workup excluded gastrointestinal obstruction, cardiac anomalies, hematologic/metabolic disorders, and endocrinopathies. Whole-exome sequencing did not identify a genetic cause.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatment was used and what was the outcome?",{"text":122,"@type":114},"The neonate required brief ventilatory support and underwent therapeutic paracentesis, removing 450 mL of straw-colored fluid. Serial ultrasounds confirmed resolution, and the infant achieved full enteral feeding with normal growth; maternal symptoms resolved after delivery.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},407063,1790764825,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","e-ISSN 1941-5923  \n© Am J Case Rep, 2025; 26: e949587 DOI: 10. 12659/AJCR.949587  \nReceived: 2025.04.26  \nAccepted: 2025.10.01  \nAvailable online: 2025.11.03  \nPublished: 2025.12.10  \nIsolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome: A Case Report  \nAuthors’ Contribution: Study Design A  \nData Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G  \nABCDEFG 1,2 BCE 3 ABF 1,2 EF 3 ABC 1,2 DF 1,2 ACF 1,2  \nCorresponding Author: Financial support: Conflict of interest:  \nMo’ath Abu Hamdeh Rasmea Mohammad Asad Zeidan Abdalsalam Mohammad Maraqah Lema Saleh Khaled Jaber Mai M. R. Rostom  \nMajed Methqal Abu Jaish  \n1 Faculty of Medicine, An Najah National University, Nablus, Occupied Palestinian Territory  \n2 Department of Pediatrics, Women’s Union Hospital, Nablus, Occupied Palestinian Territory  \n3 Faculty of Medicine, Hebron, University, Hebron, Occupied Palestinian Territory  \nMo’ath Abu Hamdeh, e-mail: [Dr.mouath_abu_hamdah@yahoo.com](Dr.mouath_abu_hamdah@yahoo.com)  \nNone declared  \nNone declared  \nPatient: Female, neonate  \nFinal Diagnosis: Congenital ascites • isolated fetal ascites • isolated transient neonatal ascites • transient neonatal ascites  \nSymptoms: Abdomen distension • dyspnea  \nClinical Procedure: Foley catheterization • intubation • paracentesis • ultrasonography  \nSpecialty: Critical Care Medicine • Genetics • Pediatrics and Neonatology  \nObjective: Unknown etiology  \nBackground: Isolated fetal and neonatal ascites is uncommon and poses substantial diagnostic and management challenges due to its diverse etiologies, which may include genitourinary or gastrointestinal malformations, infections, cardiac anomalies, and genetic disorders. Mirror syndrome, or Ballantyne syndrome, is a rare maternal complication typically associated with hydrops fetalis and characterized by maternal edema that “mirrors” the fetus and placenta, often mimicking preeclampsia. Its occurrence in conjunction with isolated fetal ascites is exceptionally rare, making recognition and management complex.  \nCase Report: A female infant was delivered at 32 weeks of gestation after progressive isolated fetal ascites had been detected on routine prenatal ultrasound. The mother developed generalized edema and rapid weight gain consistent with mirror syndrome but without hypertension or proteinuria. Extensive maternal evaluation, including TORCH screening and karyotyping, yielded unremarkable results. Postnatal investigations excluded gastrointestinal obstruction, cardiac anomalies, hematologic or metabolic disorders, and endocrinopathies. Whole-exome sequencing did not identify a genetic cause. The neonate required brief ventilatory support and underwent therapeutic paracentesis, which removed 450 mL of straw-colored fluid, resulting in rapid improvement without recurrence. Serial postnatal ultrasounds confirmed resolution of the ascites; the infant achieved full enteral feeding with normal growth parameters. The mother’s symptoms also resolved shortly after delivery.  \nConclusions: This case highlights the rare association between isolated fetal ascites and maternal mirror syndrome. When severe etiologies are excluded, conservative neonatal management with paracentesis and close monitoring can yield favorable outcomes. A thorough multidisciplinary approach is essential, and continued follow-up is warranted to identify any late-emerging conditions.  \nKeywords: Whole Genome Sequencing • Hydrops Fetalis  \nAbbreviation: WES – whole-exome sequencing; TORCH – toxoplasmosis, other agents, rubella, cytomegalovirus, herpes simplex  \nFull-text PDF: [https://www.amjcaserep.com/abstract/index/idArt/949587](https://www.amjcaserep.com/abstract/index/idArt/949587)  \n2228  1  3  20  \nPublisher’s note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of ","cbCaiaDBOL4QyeSF","https://ap.wps.com/l/cbCaiaDBOL4QyeSF","pdf",549254,"English","# Introduction\n## Case Report\n## Conclusions","[{\"question\":\"What clinical scenario does the case describe?\",\"answer\":\"The case describes isolated transient neonatal ascites in a preterm infant born to a mother with mirror syndrome, a rare maternal complication.\"},{\"question\":\"How was the underlying cause evaluated?\",\"answer\":\"Maternal evaluation included TORCH screening and karyotyping; postnatal workup excluded gastrointestinal obstruction, cardiac anomalies, hematologic/metabolic disorders, and endocrinopathies. Whole-exome sequencing did not identify a genetic cause.\"},{\"question\":\"What treatment was used and what was the outcome?\",\"answer\":\"The neonate required brief ventilatory support and underwent therapeutic paracentesis, removing 450 mL of straw-colored fluid. Serial ultrasounds confirmed resolution, and the infant achieved full enteral feeding with normal growth; maternal symptoms resolved after delivery.\"}]","Isolated Transient Neonatal Ascites in a Preterm Infant Born to a Mother with Mirror Syndrome - A Case Report | PDF",1790569995,18]