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Metastases most often involve the liver and lungs, but atypical metastatic sites can occur. This case describes a 68-year-old male presenting with obstructive jaundice caused by an isolated hilar liver mass that mimicked cholangiocarcinoma. Percutaneous biopsies with immunostaining established metastatic colon adenocarcinoma, enabling multidisciplinary biliary decompression and chemotherapy planning.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/isolated-hilar-mass-mimicking-cholangiocarcinoma-as-a-rare-metastatic-manifestation-of-recurrent-colorectal-cancer-a-case-report/406567/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/isolated-hilar-mass-mimicking-cholangiocarcinoma-as-a-rare-metastatic-manifestation-of-recurrent-colorectal-cancer-a-case-report/406567.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why was the liver hilar mass initially mistaken for cholangiocarcinoma?","Question",{"text":112,"@type":113},"The isolated hilar mass mimicked cholangiocarcinoma (Klatskin’s tumor). The correct diagnosis required pathology and immunostaining to identify metastatic adenocarcinoma originating from the colon.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What diagnostic method confirmed the source of the hilar mass?",{"text":117,"@type":113},"Percutaneous biopsies obtained by interventional radiology provided tissue for pathology, confirming metastatic adenocarcinoma originating from the colon.",{"name":119,"@type":110,"acceptedAnswer":120},"How was treatment planned given the patient’s surgical eligibility?",{"text":121,"@type":113},"The patient was not considered a surgical candidate and pursued chemotherapy. Biliary decompression was performed either endoscopically or percutaneously as part of multidisciplinary oncology care.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406567,1790963255,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","| W | J | G | P | World Journal of\u003Cbr>Gastrointestinal Pathophysiology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Pathophysiol 2025 December 22; 16(4): 111865  \nDOI: 10.4291/wjgp.v16.i4.111865 ISSN 2150-5330 (online)  \nCASE REPORT  \nIsolated hilar mass mimicking cholangiocarcinoma as a rare metastatic manifestation of recurrent colorectal cancer: A case report  \nNisar Amin, Ebubekir Daglilar, Harleen Kaur Chela  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C, Grade D  \nNovelty: Grade B, Grade C  \nCreativity or Innovation: Grade C, Grade D  \nScientific Significance: Grade C, Grade D  \nP-Reviewer: Hasbahceci M, MD, Professor, Türkiye; Raut S, MD, Assistant Professor, India  \nReceived: July 14, 2025  \nRevised: August 30, 2025  \nAccepted: November 27, 2025  \nPublished online: December 22, 2025  \nProcessing time: 164 Days and 2 Hours  \nNisar Amin, Department of Internal Medicine, Charleston Area Medical Center, Charleston, WV 25304, United States  \nEbubekir Daglilar, Department of Gastroenterology and Hepatology, West Virginia UniversityCharleston Division, Charleston, WV 25304, United States  \nHarleen Kaur Chela, Department of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University School of Medicine, Charleston, WV 25304, United States  \nCorresponding author: Harleen Kaur Chela, Assistant Professor, Department of Gastroenterology and Hepatology, Charleston Area Medical Center, West Virginia University School of Medicine, 64 Medical Center Drive, Charleston, WV 25304, United States.  \n[harleen.chela@camc.org](harleen.chela@camc.org)  \nAbstract  \nBACKGROUND  \nColorectal cancer remains as one of the most common cancers that are diagnosed and remains as a significant contributor to morbidity and mortality. Despite advances in techniques, improving access to diagnostic modalities and increasing awareness, it often presents at a later stage and can recur despite treatment. Recurrence can be variable and can occur years after treatment. Liver is the most common location for metastasis to occur followed by lungs. However, atypical sites of metastasis can occur although unusual and colorectal cancer can spread to the spleen, hilum of the liver, adrenals, bone, skeletal muscles, skin, prostate, brain, parotid gland, thyroid gland and even the cardiac muscle. It is crucial to recognize the metachronous nature of the metastasis and to only present at a single site as within this lies the rarity of the case. The mass itself mimicked acholangiocarcinoma or a Klatskin’s tumor initially and only through pathology was the diagnosis established. We present an unusual case of recurrent colorectal cancer that occurred several years post treatment and presented as an isolated metastasis to the hilum of the liver leading to biliary obstruction without anyother identifiable lesions including in the colon itself.  \nCASE SUMMARY  \nA 68-year-old male with history of colon cancer presented with obstructive jaundice to the hospital. After evaluation with imaging studies was diagnosed  \n WJGP  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 22, 2025  Volume 16  Issue 4   \nAmin N et al. Isolated hilar mass mimicking cholangiocarcinoma  \nwith mass at the hilum of the liver that was leading to obstruction. With percutaneous biopsies obtained by interventional radiology, the diagnosis of metastatic adenocarcinoma originating from the colon was established. He was deemed not to be a surgical candidate and is currently pursuing chemotherapy.  \nCONCLUSION  \nA metastatic adenocarcinoma of the colon that presents as a hilar mass and mimics cholangiocarcinoma is very rare. The metachronous nature along with the isolated metastasis involving the hilum of th","cbCaioeJKOW1zB5t","https://ap.wps.com/l/cbCaioeJKOW1zB5t","pdf",5973359,"English","# Abstract\n## Background\n## Case summary\n## Conclusion\n# Introduction\n# Case report\n# Conclusion","[{\"question\":\"Why was the liver hilar mass initially mistaken for cholangiocarcinoma?\",\"answer\":\"The isolated hilar mass mimicked cholangiocarcinoma (Klatskin’s tumor). The correct diagnosis required pathology and immunostaining to identify metastatic adenocarcinoma originating from the colon.\"},{\"question\":\"What diagnostic method confirmed the source of the hilar mass?\",\"answer\":\"Percutaneous biopsies obtained by interventional radiology provided tissue for pathology, confirming metastatic adenocarcinoma originating from the colon.\"},{\"question\":\"How was treatment planned given the patient’s surgical eligibility?\",\"answer\":\"The patient was not considered a surgical candidate and pursued chemotherapy. Biliary decompression was performed either endoscopically or percutaneously as part of multidisciplinary oncology care.\"}]","Isolated hilar mass mimicking cholangiocarcinoma as a rare metastatic manifestation of recurrent colorectal cancer - A case report | PDF",1790566471]