[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-446397-105":59,"doc-detail-446397-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","isolated-goat-and-sheep-milk-allergy-in-an-adult-in-the-absence-of-bovine-sensitization","Isolated goat and sheep milk allergy in an adult in the absence of bovine sensitization","","Cow’s milk allergy is the most common food allergy in children, but cross-reactivity with goat and sheep milk proteins is usually discussed in pediatric settings. Isolated goat and sheep milk allergy in cow’s milk–tolerant individuals is rare and poorly documented. This case report describes a 27-year-old Mediterranean man with two anaphylaxis episodes after sheep and goat cheese while tolerating cow’s milk. Skin prick testing confirmed sensitization to goat/sheep milk but not cow’s milk. The report reviews mechanisms and clinical implications for adult-onset isolated mammalian milk protein allergy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/isolated-goat-and-sheep-milk-allergy-in-an-adult-in-the-absence-of-bovine-sensitization/446397/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/isolated-goat-and-sheep-milk-allergy-in-an-adult-in-the-absence-of-bovine-sensitization/446397.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is isolated goat and sheep milk allergy, and why is it uncommon?","Question",{"text":113,"@type":114},"It refers to allergy to goat/sheep milk (GSM) proteins in people who tolerate cow’s milk (CM). It is uncommon because most GSM-allergic patients also show concurrent CM sensitization.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was sensitization to milk types assessed in the adult case?",{"text":118,"@type":114},"The report used skin prick testing with appropriate controls. Results were positive for GSM products but negative for CM, supporting isolated GSM sensitization.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical guidance does the report emphasize for reacting to dairy products?",{"text":122,"@type":114},"Clinicians should consider GSM sensitization when patients present with allergic reactions to dairy, particularly in multicultural populations where GSM dietary exposure may be increasing.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},446397,1790794336,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Aw and Sussman Allergy, Asthma & Clinical Immunology (2026) 22:3 [https://doi.org/10.1186/s13223-025-00996-x](https://doi.org/10.1186/s13223-025-00996-x)  \nAllergy, Asthma & Clinical Immunology  \nCASE REPORT Open Access  \nIsolated goat and sheep milk allergy in an adult in the absence of bovine sensitization  \nMichael Aw 1* and Gordon Sussman2  \nAbstract  \nCow’s milk (CM) allergy is the most common food allergy in children, with cross-reactivity to goat and sheep milk (GSM) representing a common outcome due to high protein homology. However, isolated GSM allergy in CM-tolerant individuals is rare and poorly documented in the literature. We describe a 27-year-old male of Mediterranean origin who experienced two episodes of anaphylaxis after consuming sheep and goat cheese, despite regular CM consumption. Skin prick testing confirmed sensitization to GSM but not CM. This report contributes to the growing evidence of adult-onset isolated GSM allergy. Isolated GSM allergy typically presents later in life and may be underrecognized due to limited clinical awareness. We review the potential for speciesspecific mammalian milk protein allergy, likely mediated by structural differences in casein proteins. Clinicians should be cognisant to consider GSM sensitization in patients presenting with allergic reactions to dairy products, especially in multicultural populations with increasing GSM dietary exposure.  \nKeywords Milk protein allergy, Anaphylaxis, Case report  \nIntro  \nCow’s milk (CM) allergy is the most common allergy in young children affecting up to 3% of the pediatric population [2]. CM allergy manifests through IgE and non-IgE mechanisms with most children developing immunologic tolerance by adolescence. Similarly, other mammalians milks such goat and sheep [1] share generally > 88% protein homology with CM resulting in frequent species cross-reactivity [2]. Approximately 90% of patients with GSM allergy are concurrently CM sensitized [3]. However, isolated GSM allergy in the absence of CM hypersensitivity is rare and our current understanding is  \n*Correspondence:  \nMichael Aw  \n[michael.aw@mail.mcgill.ca](michael.aw@mail.mcgill.ca)  \n1Department of Internal Medicine, Faculty of Medicine, McGill University Health Centre (MUHC), 1001 Decarie Boulevard, Montreal, QC  \nH4A 3J1, Canada  \n2Division of Allergy & Clinical Immunology, University of Toronto, Toronto, ON, Canada  \nlimited to case report and case series data. We present a case of a 27-year-old male who experienced anaphylaxis following consumption of GSM cheese who was otherwise CM tolerant.  \nCase  \nA 27-year-old male of Mediterranean origin was referred for allergist evaluation for a suspected sesame allergy. He was known for allergic rhinitis with sensitizations to house dust mite, birch, ragweed, cat, dog and Alternaria mould. He had no other medical history and did not use regular medication or consume recreational drugs. The patient had consumed a meal with cheese and black sesame and subsequently developed immediate severe nausea, throat tightness, dyspnea and diffuse urticaria. He was subsequently treated with intramuscular epinephrine in the emergency room.  \nThe patient underwent skin prick testing (SPT) with appropriate histamine and 0.9% saline buffer control responses that was negative to fresh sesame and sesame  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not ","cbCaikCtxBWAzabQ","https://ap.wps.com/l/cbCaikCtxBWAzabQ","pdf",846118,"English","# Abstract\n# Introduction\n# Case\n## Episode 1: Sheep and goat cheese exposure\n## Episode 2: Goat’s milk cheese exposure\n# Ethics and licensing","[{\"question\":\"What is isolated goat and sheep milk allergy, and why is it uncommon?\",\"answer\":\"It refers to allergy to goat/sheep milk (GSM) proteins in people who tolerate cow’s milk (CM). It is uncommon because most GSM-allergic patients also show concurrent CM sensitization.\"},{\"question\":\"How was sensitization to milk types assessed in the adult case?\",\"answer\":\"The report used skin prick testing with appropriate controls. Results were positive for GSM products but negative for CM, supporting isolated GSM sensitization.\"},{\"question\":\"What clinical guidance does the report emphasize for reacting to dairy products?\",\"answer\":\"Clinicians should consider GSM sensitization when patients present with allergic reactions to dairy, particularly in multicultural populations where GSM dietary exposure may be increasing.\"}]","Isolated goat and sheep milk allergy in an adult in the absence of bovine sensitization | PDF",1790715270,13]