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Fifty-seven patients treated between 1 January 2022 and 31 December 2024 underwent histopathological classification by thrombus composition and stage, with CD34 staining used to identify organized fibrin. Results show composition varies with anatomical location, while CD34 positivity does not significantly correlate with thrombus composition or comorbidities. Findings indicate a complex link among histopathology, anatomy, and procedure outcomes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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fibrin.",{"name":70,"@type":61,"acceptedAnswer":71},"Did CD34 positivity correlate with thrombus composition or comorbidities?",{"text":72,"@type":64},"No. CD34 positivity did not show a statistically significant relationship with thrombus composition (p > 0.05), and no notable associations were found between thrombus composition and chronic comorbidities.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},465473,1790846961,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases?  \nSaim Türko ˘glu 1, *, Hüseyin Akdeniz 1, Ertu ˘g Günsoy 2 and Fatma Ayaz Yalınkılıç 3  \nAcademic Editor: Tomasz Litwin  \nReceived: 9 November 2025  \nRevised: 7 December 2025  \nAccepted: 20 December 2025  \nPublished: 24 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Radiology, Medical Faculty, Yuzuncu Yıl University, 65080 Van, Turkey; [hakdenizdr@hotmail.com](hakdenizdr@hotmail.com)  \n2 Emergency Clinic, Van Training and Research Hospital, University of Health Sciences, 65080 Van, Turkey; [gunsoyertug@gmail.com](gunsoyertug@gmail.com)  \n3 Department of Pathology, Medical Faculty, Yuzuncu Yıl University, 65080 Van, Turkey; [dr.fatma_ayaz@hotmail.com](dr.fatma_ayaz@hotmail.com)  \n* [Correspondence: mdsaimturkoglu@gmail.com](Correspondence: mdsaimturkoglu@gmail.com); Tel.: +90-535-645-2865; Fax: +90-432-216-8519  \nAbstract  \nObjective: This study aimed to assess the association between the histopathological characteristics of thrombi extracted during endovascular thrombectomy and clinical factors, including the location of the occlusion, comorbid conditions, and treatment effectiveness, in patients with acute ischemic stroke. Materials and Methods: A total of 57 patients with acute ischemic stroke who underwent endovascular thrombectomy between 1 January 2022 and 31 December 2024 were included in the study. Thrombi were analyzed histopathologically and classified into categories based on their composition (RBC-dominant, fibrindominant, RBC = fibrin, organized fibrin) and phase (early or late stage) . CD34 staining was used to assess organized fibrin. Results: The mean age of the patients was 65.2 ± 15.3 years, 52.6% were female, and 47.4% were male. The majority of thrombi were retrieved from the MCA M1 segment (64.9%) . Histopathological analysis revealed that 49.1% of thrombi were RBC-dominant, 21.1% RBC = fibrin, 19.3% fibrin-dominant, and 10.5% contained organized fibrin. Early-stage thrombi accounted for 70.2% of cases, while late-stage thrombi comprised 29.8% . Thrombus composition was significantly associated with anatomical location, with RBC-dominant thrombi being most prevalent in the proximal ICA (88.2%; p \u003C 0.001) . CD34 staining identified organized fibrin in 10.5% of thrombi, exclusively inpatients who underwent stent placement. However, no statistically significant correlation was identified between CD34 positivity and thrombus composition (p > 0.05) . Additionally, no notable associations were found between thrombus composition and chronic comorbidities. Conclusions: Thrombus composition and stage exhibit variability depending on anatomical location, particularly in the proximal ICA, where RBC-dominant thrombi are more frequent. Although CD34 positivity indicates organized fibrin, it does not showa significant relationship with thrombus characteristics or patient comorbidities. These findings underscore the complex interplay between thrombus histopathology, anatomical location, and procedural outcomes, highlighting the need for further investigation.  \nKeywords: acute ischemic stroke; comorbidity; endovascular thrombectomy; histopathological; thrombi  \n1. Introduction  \nThe most effective strategy for preserving viable ischemic brain tissue in the treatment of acute ischemic stroke is the timely restoration of cerebral blood flow through reperfusion therapy [1] . In recent years, advanced treatments such as mechanical thrombectomy (MT) using catheter-based devices have become standard practice. MT has been demonstrated to significantly enhance outcomes in patients with acute large vessel occlusion stroke. Additionally, it off","cbCait0TKaIHPvCt","https://ap.wps.com/l/cbCait0TKaIHPvCt","pdf",6069925,"English","# Abstract\n# Introduction\n# Materials and Methods","[{\"question\":\"What was the primary objective of this study?\",\"answer\":\"To determine whether histopathological features of thrombi obtained during endovascular thrombectomy are associated with occlusion location, comorbid conditions, and treatment effectiveness in acute ischemic stroke patients.\"},{\"question\":\"How were thrombi classified in the Materials and Methods?\",\"answer\":\"Thrombi were analyzed histopathologically and categorized by composition (RBC-dominant, fibrin-dominant, RBC = fibrin, organized fibrin) and by phase (early or late stage), with CD34 staining used to assess organized fibrin.\"},{\"question\":\"Did CD34 positivity correlate with thrombus composition or comorbidities?\",\"answer\":\"No. CD34 positivity did not show a statistically significant relationship with thrombus composition (p \\u003e 0.05), and no notable associations were found between thrombus composition and chronic comorbidities.\"}]","Is There a Relationship Between the Histopathological Features and Anatomical Locations of Thrombi Obtained During Endovascular Thrombectomy in Acute Ischemic Stroke and Its Comorbid Diseases - Research Findings | PDF",1790769669,48]