[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372572-105":59,"doc-detail-372572-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","is-pyroptosis-a-brake-or-an-accelerator-in-the-fate-of-the-tumor","Is pyroptosis a brake or an accelerator in the fate of the tumor?","","Review article analyzing pyroptosis as both a programmed and highly inflammatory immunogenic cell death process and its impact on tumor fate. It explains how pyroptosis promotes antitumor immunity by triggering gasdermin-mediated pore formation, cytokine and inflammatory mediator release, immune recruitment, and self-amplifying inflammatory feedback. The review also summarizes links among pyroptosis, inflammation, and tumors, and discusses nano-targeting materials and combined therapeutic patterns to improve anticancer treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/is-pyroptosis-a-brake-or-an-accelerator-in-the-fate-of-the-tumor/372572/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/is-pyroptosis-a-brake-or-an-accelerator-in-the-fate-of-the-tumor/372572.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is pyroptosis and how does it work at the cellular level?","Question",{"text":113,"@type":114},"Pyroptosis is a programmed, highly inflammatory immunogenic cell death. It involves gasdermin-mediated pore formation, osmotic imbalance, membrane rupture, and release of intracellular cytokines and inflammatory mediators.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is pyroptosis considered important for antitumor immunotherapy?",{"text":118,"@type":114},"The review states that pyroptosis can accelerate cancer cell death and help reverse immunosuppression by provoking strong proinflammatory responses and activating immune clearance of tumor-related targets.",{"name":120,"@type":111,"acceptedAnswer":121},"How do nanotherapies relate to pyroptosis in cancer treatment?",{"text":122,"@type":114},"The article highlights that combining nanotherapies with pyroptosis has potential to eradicate tumor cells and improve cancer treatment, including through nano-targeting therapeutic strategies.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},372572,1790467604,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www.nature.com/cddis](www.nature.com/cddis)  \nREVIEW ARTICLE OPEN   \nIs pyroptosis a brake or an accelerator in the fate of the tumor?  \nYixuan Hou 1, Wei Li1, Jiaying Yang1, Haoyang Yu1, Congcong Wang1, Yanru Li 1, Shuang Lv1 and Ling Zhang 1 ✉  \n© The Author(s) 2025  \n\n|  | Cancer currently stands as a formidable challenge confronting humanity. Patients afflicted with malignancies typically endure diminished survival rates and compromised quality of life. Consequently, the paramount objective of oncological research lies in redefining cancer from a terminal diagnosis to a clinically manageable condition, thereby realizing this transformative medical paradigm. The development of multiple innovative therapeutic strategies may enhance the antitumor immune response. Notably, pyroptosis is considered both a form of programmed cell death and a highly inflammatory type of immunogenic cell death. Its activation may accelerate cancer cell death and exert antitumor effects as a promising scenario to reverse immunosuppression. This article elaborates on the following three main aspects: the molecular mechanisms underlying pyroptosis and the development of promising therapeutics that target pyroptosis, the relationship between pyroptosis, inflammation, and tumors, and the application of nano-targeting materials in tumor treatments. These interactive therapeutic patterns may catalyze a paradigm shift in oncology. In this review, we probe the synergistic effects of pyroptosis and nanomaterials, forecast achievements in the field of tumor treatments, detail optimized therapeutic strategies, and shed promising light on the potential for the improvement and |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| development of clinical drugs based on pyroptosis. |  |  |\n|  | Cell Death and Disease (2025)16:568; [https://doi.org/10.1038/s41419-025-07866-9](https://doi.org/10.1038/s41419-025-07866-9) |  |\n|  |  |  |\n\nFACTS  \n● Multiple innovative therapeutic strategies are needed to improve antitumor immunotherapy.  \n● A keen understanding of the process of cell death is needed to develop preventative and targeted therapies for cancer.  \n● Pyroptosis is a type of programmed cell death, and triggering pyroptosis may activate an immune response to tumors.  \n● Combining nanotherapies with pyroptosis has the potential to successfully eradicate tumor cells and potentially improve the treatment of cancer.  \nINTRODUCTION  \nCancer, a serious priority public health issue, accounts for a large proportion of the primary causes of death worldwide because of its high incidence and mortality [1] . This has resulted in an increased burden on families and society and adverse effects on the well-being of patients. In previous studies detailing the treatments of cancers, the prevailing approach was that promoting apoptosis was one of the most effective treatment methods available. However, this approach to anti-tumor treatment has flaws, as various cancers can be resistant to chemotherapy [2] . Flaws in apoptosis often cause failed anti-tumor treatments [3] . Cell death, i.e., pyroptosis, has been a recent focus among researchers because of the association with innate immunity and diseases [4] . Pyroptosis may be involved in antitumor immune response and has the potential to reverse immunosuppression [5] . Various strategies have been explored to harness pyroptosis as an  \nanti-tumor agent. Recent studies demonstrated that the induction of pyroptosis in tumor cells facilitates anti-tumor activity. The studies underlined gasdermins (GSDMs) as potential new targets for antitumor activity [6] . Pyroptosis triggers a robust proinflammatory response, starkly contrasting with the immunologically silent nature of apoptosis [7] and the moderately proinflammatory nature of necrosis [8] . Pyroptosis uniquely drives inflammation by amplifying inflammatory cascades through its distinct molecular mechan","cbCaieDcRPssHoBB","https://ap.wps.com/l/cbCaieDcRPssHoBB","pdf",1843088,"English","# Introduction\n# Key facts\n# Molecular mechanisms of pyroptosis\n# Pyroptosis, inflammation, and tumors\n# Nano-targeting materials and tumor treatment applications","[{\"question\":\"What is pyroptosis and how does it work at the cellular level?\",\"answer\":\"Pyroptosis is a programmed, highly inflammatory immunogenic cell death. It involves gasdermin-mediated pore formation, osmotic imbalance, membrane rupture, and release of intracellular cytokines and inflammatory mediators.\"},{\"question\":\"Why is pyroptosis considered important for antitumor immunotherapy?\",\"answer\":\"The review states that pyroptosis can accelerate cancer cell death and help reverse immunosuppression by provoking strong proinflammatory responses and activating immune clearance of tumor-related targets.\"},{\"question\":\"How do nanotherapies relate to pyroptosis in cancer treatment?\",\"answer\":\"The article highlights that combining nanotherapies with pyroptosis has potential to eradicate tumor cells and improve cancer treatment, including through nano-targeting therapeutic strategies.\"}]","Is pyroptosis a brake or an accelerator in the fate of the tumor? | PDF",1790194848,28]