[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-377904-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-377904-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","is-metabolism-the-magic-bullet-for-targeted-cancer-therapy-editorial","Is metabolism the magic bullet for targeted cancer therapy? - editorial","","Altered cellular metabolism is a hallmark of cancer, driven by oncogenic signaling that rewires metabolic programs to sustain tumorigenesis, therapy resistance, and metastasis. The editorial in BMC Cancer frames the “Cancer Metabolism” collection as a focus on how personalized medicine can target metabolic dependencies for cancer therapy. It outlines how cancer cells survive by adapting to available nutrients and energy, and it highlights key historical and contemporary evidence, including aerobic glycolysis and mitochondrial function.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/is-metabolism-the-magic-bullet-for-targeted-cancer-therapy-editorial/377904/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/is-metabolism-the-magic-bullet-for-targeted-cancer-therapy-editorial/377904.png","ImageObject",300,407,{"name":42,"@type":43},"Aurelia","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is altered metabolism considered a hallmark of cancer?","Question",{"text":63,"@type":64},"Because oncogenic signaling induces metabolic rewiring that supports tumor growth, therapy resistance, and metastasis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What does the editorial emphasize about the research focus for cancer metabolism?",{"text":68,"@type":64},"It highlights current views and research efforts aimed at personalized medicine strategies to target metabolism in cancer therapy.",{"name":70,"@type":61,"acceptedAnswer":71},"What are the main drawbacks of cell culture for metabolic experiments?",{"text":72,"@type":64},"Cell culture lacks microenvironmental support and often uses non-physiological nutrient concentrations that can bias metabolic findings and drug response outcomes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},377904,1790763632,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":111},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Trajkovic-Arsic and Subramani BMC Cancer (2023) 23:484 BMC Cancer  \n[https://doi.org/10.1186/s12885-023-10999-9](https://doi.org/10.1186/s12885-023-10999-9)  \nEDITORIAL Open Access  \nIs metabolism the magic bullet for targeted cancer therapy?  \nMarija Trajkovic-Arsic1,2* and Elavarasan Subramani3*  \nAbstract  \nAltered cellular metabolism has long been recognized as a hallmark of cancer. Oncogenic signaling cascades induce metabolic rewiring that further supports tumorigenesis, therapy resistance and metastasis. In view of this, the Collection on ‘Cancer Metabolism’ highlights the current views and focus of research on personalized medicine approach to target metabolism for cancer therapy.  \nBackground  \nThe last years of research have taught us that cancer is avery complex, multifaceted disease. Despite being “bodyown”, cancer cells build up an aggressive, self-sustaining ecosystem with the aim of surviving, expanding and ultimately defeating the host. No matter how different the cancer from a normal cell, they rely on the same fundamental needs for nutrients and energy. While there are a few metabolic signatures that are unique to cancer cells and not found in normal cells, the metabolic processes are overall similar. The advantage of a cancer cell lies in its ability to rewire and adapt its metabolism to whatever source of food and energy is available. Activated oncogenes and signaling networks trigger alternative catabolic  \n*Correspondence:  \nMarija Trajkovic-Arsic [marija.trajkovic-arsic@uk-essen.de](marija.trajkovic-arsic@uk-essen.de)[ ](marija.trajkovic-arsic@uk-essen.de)Elavarasan Subramani[esubramani@mdanderson.org](esubramani@mdanderson.org)  \n1Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany  \n2West German Cancer Center, Bridge Institute of Experimental Tumor Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany  \n3Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA  \nand anabolic processes that enable cancer cells to use substitute resources and improvise as needed.  \nThe history of cancer metabolism started nearly a hundred years ago when Otto Warburg discovered aerobic glycolysis and lactate production in cultured tumor slices despite the availability of sufficient oxygen [1]. Warburg assumed that mitochondrial respiration is deficient in cancers for unknown reasons. Nowadays, we know that mitochondria are rarely damaged in cancers and genes coding for mitochondrial enzymes are highly preserved and rarely mutated, suggesting how essential and conserved respiration in cancers is. The activation of glycolysis as a process is nothing else but satisfying the need of a proliferating cancer cell for glycolytic inter-metabolites, ribose and hexose sugars that support nucleotide synthesis and protein glycosylation [2, 3]. Beyond glucose, cancer cells utilize alternative fuels to meet their energy demand which warrants further investigation for a complete characterization of cancer metabolism. Recent works emphasize that glycolysis is necessary for theregeneration of high NAD +levels needed for increased proliferation [4, 5]. Furthermore, cancer cells can scavenge the necessary nutrients from the microenvironment to promote the different steps of metastasis [6].  \nThere are many factors to consider when performing and interpreting metabolic experiments. The broad variety of models ranging from in vitro 2D-, 3D-, co-culture  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party m","cbCaisbzhDnrWKC3","https://ap.wps.com/l/cbCaisbzhDnrWKC3","pdf",627448,"English","# Abstract\n# Background\n## Cancer metabolism and metabolic rewiring\n## Historical perspective and key pathways\n## Nutrient sources and metastasis support\n# Metabolic experiments and interpretation","[{\"question\":\"Why is altered metabolism considered a hallmark of cancer?\",\"answer\":\"Because oncogenic signaling induces metabolic rewiring that supports tumor growth, therapy resistance, and metastasis.\"},{\"question\":\"What does the editorial emphasize about the research focus for cancer metabolism?\",\"answer\":\"It highlights current views and research efforts aimed at personalized medicine strategies to target metabolism in cancer therapy.\"},{\"question\":\"What are the main drawbacks of cell culture for metabolic experiments?\",\"answer\":\"Cell culture lacks microenvironmental support and often uses non-physiological nutrient concentrations that can bias metabolic findings and drug response outcomes.\"}]","Is metabolism the magic bullet for targeted cancer therapy? - editorial | PDF",1790227574]