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This study reviews a 2015–2020 single-institution experience, initially including 10 patients with imaging evidence of apparent adjacent cardiovascular invasion, and evaluates CPB’s role through operative outcomes, perioperative safety, and long-term survival. Ultimately, 8 patients received salvage or elective CPB resections, with 2 completing surgery without CPB.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/is-extended-resection-for-locally-advanced-thoracic-cancer-with-cardiopulmonary-bypass-justified-research-open-access/332666/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/is-extended-resection-for-locally-advanced-thoracic-cancer-with-cardiopulmonary-bypass-justified-research-open-access/332666.png","ImageObject",300,407,{"name":42,"@type":43},"Sage","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about cardiopulmonary bypass (CPB)?","Question",{"text":63,"@type":64},"The study evaluates whether extended resection for locally advanced thoracic cancers using CPB is justified, focusing on perioperative safety and survival outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Who were the patients and how many ultimately received CPB?",{"text":68,"@type":64},"Between 2015 and 2020, 10 patients were initially included based on imaging evidence of adjacent cardiovascular invasion; ultimately, 8 patients received salvage or elective resection with CPB, while 2 completed surgery without CPB.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about mortality and long-term outcomes?",{"text":72,"@type":64},"Thirty-day mortality occurred in two of three patients undergoing salvage surgery due to respiratory insufficiency. Longer follow-up found one recurrence-related death at 25 months, one patient survived with recurrence at 30 months, and four patients remained alive without recurrence after 35, 36, 49, and 107 months.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332666,1790974747,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Hsu etal. BMC Surgery (2024) 24:334 [https://doi.org/10.1186/s12893-024-02632-8](https://doi.org/10.1186/s12893-024-02632-8)  \nBMC Surgery  \nRESEARCH Open Access  \nIs extended resection for locally advanced  thoracic cancer with cardiopulmonary bypass justified?  \nJoffrey Hsu 1†, Ping-Ruey Chou2,3†, Jiann-Woei Huang4, Yu-Wei Liu 1*, Hung-Hsing Chiang 1, Jui-Ying Lee 1, Hsien-Pin Li 1, Po-Chih Chang 1 and Shah-Hwa Chou 1  \nAbstract  \nBackground Resection of intrathoracic tumor with cardiopulmonary bypass (CPB) remains a relatively underreported intervention in literature, and its role in managing locally advanced mediastinal and lung cancers is a topic of ongoing debate. Our aim was to review our experience and assess the role of CPB for treating locally advanced mediastinal and lung cancers.  \nMethods Between 2015 and 2020, this study initially included 10 patients with primary locally advanced thoracic malignancies with apparent adjacent cardiovascular invasion demonstrated by thoracic imaging scans. Operation was performed based on a multidisciplinary tumor board consensus. Eventually, 8 patients (3 primary lung cancers and 5 mediastinal cancers) received either salvage or elective resection with CPB; two completed surgery without requiring CPB.  \nResults Regarding the extent of adjacent structure involvement, 4 patients presented with involvement of the superior vena cava (SVC), 1 involved the right atrium (RA), 2 involved the SVC and RA, and 1 involved the SVC, the origin of main pulmonary artery, and the ascending aorta. Thirty-day mortality occurred in two of three patients receiving salvage surgery due to respiratory insufficiency. With the long-term follow-up, one patient died of recurrence 25 months postoperatively, one survived with recurrence 30 months postoperatively, and four were alive without recurrence for 35, 36, 49, and 107 months after operations.  \nConclusion In certain patients, particularly for elective surgical candidates rather than salvage resection, CPB allows for extended resection of locally advanced thoracic cancers with acceptable perioperative safety and survival. Keywords Cardiopulmonary bypass (CPB), Extended resection, Locally advanced thoracic cancer  \n†Joffrey Hsu and Ping-Ruey Chou contributed equally to this work.  \n*Correspondence:  \nYu-Wei Liu  \n[nipma6714@gmail.com](nipma6714@gmail.com)  \n1Division of Thoracic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 80756, Taiwan  \n2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80756, Taiwan  \n3Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan  \n4Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://](http://)[ ](http://)[creativecommons.org/l](creativecommons.org/","cbCaipSqp2FxfPHD","https://ap.wps.com/l/cbCaipSqp2FxfPHD","pdf",2714040,"English","# Background\n# Methods\n## Study design\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What question does the study address about cardiopulmonary bypass (CPB)?\",\"answer\":\"The study evaluates whether extended resection for locally advanced thoracic cancers using CPB is justified, focusing on perioperative safety and survival outcomes.\"},{\"question\":\"Who were the patients and how many ultimately received CPB?\",\"answer\":\"Between 2015 and 2020, 10 patients were initially included based on imaging evidence of adjacent cardiovascular invasion; ultimately, 8 patients received salvage or elective resection with CPB, while 2 completed surgery without CPB.\"},{\"question\":\"What did the results show about mortality and long-term outcomes?\",\"answer\":\"Thirty-day mortality occurred in two of three patients undergoing salvage surgery due to respiratory insufficiency. Longer follow-up found one recurrence-related death at 25 months, one patient survived with recurrence at 30 months, and four patients remained alive without recurrence after 35, 36, 49, and 107 months.\"}]","Is extended resection for locally advanced thoracic cancer with cardiopulmonary bypass justified - Research Open Access | PDF",1789999027,25]