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Serum measurements were obtained from 89 adults stratified into four groups: controls without NAFLD, preobese/obese without NAFLD, and preobese/obese with grade 1 and grade 2–3 NAFLD. Results show reduced serum irisin and adropin in grade 1–3 NAFLD versus controls, without a difference between grades. The findings also report a higher red cell distribution width in grade 1 versus controls and a higher atherogenic index in more severe NAFLD. Overall, NAFLD presence associates with lower hormone levels regardless of severity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/irisin-and-adropin-decrease-in-preobese-or-obese-individuals-with-nonalcoholic-fatty-liver-disease/455251/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/irisin-and-adropin-decrease-in-preobese-or-obese-individuals-with-nonalcoholic-fatty-liver-disease/455251.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the aim of the study?","Question",{"text":112,"@type":113},"To investigate serum irisin and adropin levels in preobese or obese adults with NAFLD and assess their relationship with NAFLD presence and severity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants grouped and how many were included?",{"text":117,"@type":113},"The study included 89 patients divided into four groups: control (normal weight, no NAFLD), preobese/obese without NAFLD, preobese/obese with grade 1 NAFLD, and preobese/obese with grade 2–3 NAFLD.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main results regarding irisin and adropin?",{"text":121,"@type":113},"Serum irisin and adropin levels were lower in grade 1 and grade 2–3 NAFLD groups than in the control group, and levels were comparable between grade 1 and grade 2–3 groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455251,1790820600,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Turkish Journal of Medical Sciences  \n\n| Volume 55  Number 6 | Article 19 |\n| --- | --- |\n| 12-12-2025\u003Cbr>Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease\u003Cbr>CUMA MERTOĞLU YAPRAK SULE ÖREKBÜLENT ALBAYRAK YUSUF KEMAL ARSLANTAHA ABDULKADİR ÇOBAN\u003Cbr>Follow this and additional works at: [https://journals.tubitak.gov.tr/medical](https://journals.tubitak.gov.tr/medical)\u003Cbr> Part of the Medical Sciences Commons |  |\n\nRecommended Citation  \nMERTOĞLU, C, ÖREK, Y. S, ALBAYRAK, B, ARSLAN, Y. K, & ÇOBAN, T. A (2025) . Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease. Turkish Journal of Medical Sciences 55 (6): 1513-1525 . [https://doi.org/10.55730/1300-0144.61](https://doi.org/10.55730/1300-0144.61)10  \nThis work is licensed under a Creative Commons Attribution 4.0 International License.  \nThis Research Article is brought to you for free and open access by TÜBİTAK Academic Journals. It has been accepted for inclusion in Turkish Journal of Medical Sciences by an authorized editor of TÜBİTAK Academic Journals. For more information, please contact [academic.publications@tubitak.gov.tr](academic.publications@tubitak.gov.tr)  \n\n| \u003Cbr>| Turkish Journal of Medical Sciences [http://journals.tubitak.gov.tr/medical/](http://journals.tubitak.gov.tr/medical/)\u003Cbr>\u003Cbr>Research Article | Turk J Med Sci\u003Cbr>(2025) 55: 1513-1525 © TÜBİTAK\u003Cbr>doi:10.55730/1300-0144.6110 |\n| --- | --- | --- |\n\nIrisin and adropin decrease in preobese or obese individuals with nonalcoholic  \nfatty liver disease  \nCuma MERTOĞLU1,2,*􀁋, Yaprak Şule ÖREK2􀁋, Bülent ALBAYRAK3􀁋, Yusuf Kemal ARSLAN4,5􀁋, Abdulkadir ÇOBAN2􀁋 1Department of Medical Biochemistry, Faculty of Medicine, İnönü University, Malatya, Turkiye  \n2  \nDepartment of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkiye 3  \nDepartment of Internal Diseases, Faculty of Medicine, Atatürk University, Erzurum, Turkiye 4  \nDepartment of Biostatistics, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan, Turkiye 5  \nDepartment of Biostatistics, Faculty of Medicine, Çukurova University, Adana, Turkiye  \nReceived: 12.01.2024  Accepted/Published Online: 03.10.2025  Final Version: 12.12.2025  \nBackground/aim: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease that is commonly observed in individuals with obesity. The present study investigates the irisin and adropin levels of sera in preobese or obese adults with NAFLD.  \nMaterials and methods: Included in the study were 89 patients who were categorized into four groups: Group 1: 25 normal-weight individuals without NAFLD (Control group); Group 2: 17 preobese or obese individuals without NAFLD; Group 3: 24 preobese or obese individuals with Grade 1 NAFLD; and Group 4: 23 preobese or obese individuals with Grade 2–3 NAFLD. The demographic details of all participants were recorded. Abdominal ultrasonography and anthropometric assessments were conducted. Serum adropin and irisin levels were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method.  \nResults: Serum adropin and irisin levels were lower in Groups 3 and 4 than in Group 1 (between the all groups; p = 0.006, p = 0.001, respectively), but were comparable between Groups 3 and 4. Furthermore, the atherogenic index of Group 1 was lower than that of Group 4 (p \u003C 0.001). Among the hemogram parameters, the red cell distribution width value was higher in Group 3 than in Group 1 (p = 0 .031) .  \nConclusion: Serum adropin and irisin levels decrease in the presence of NAFLD, regardless of disease severity, which may play a role in the development and exacerbation of NAFLD in preobese and obese individuals.  \nKey words: Nonalcoholic fatty liver disease, adropin, irisin, hematological parameters, atherogenic index  \n1. Introduction  \nNonalcoholic fatty liver disease (NAFLD) is diagnosed based on the detection of hepatic steatosis in radiological images ","cbCaiaFEbQZpDjd5","https://ap.wps.com/l/cbCaiaFEbQZpDjd5","pdf",729807,14,"English","# Background/aim\n# Materials and methods\n# Results\n# Conclusion\n# Key words\n# 1. Introduction","[{\"question\":\"What was the aim of the study?\",\"answer\":\"To investigate serum irisin and adropin levels in preobese or obese adults with NAFLD and assess their relationship with NAFLD presence and severity.\"},{\"question\":\"How were participants grouped and how many were included?\",\"answer\":\"The study included 89 patients divided into four groups: control (normal weight, no NAFLD), preobese/obese without NAFLD, preobese/obese with grade 1 NAFLD, and preobese/obese with grade 2–3 NAFLD.\"},{\"question\":\"What were the main results regarding irisin and adropin?\",\"answer\":\"Serum irisin and adropin levels were lower in grade 1 and grade 2–3 NAFLD groups than in the control group, and levels were comparable between grade 1 and grade 2–3 groups.\"}]","Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease | PDF",1790742478,35]