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The classification links nerve and muscle, growth regulation, and multi-site inhibition categories to specific compound families, and flags strength of evidence for action at targeted proteins. Tables list active ingredients spanning acetylcholinesterase inhibitors, organophosphates, chloride channel blockers, sodium channel modulators, and nicotinic receptor modulators.","| IRAC MoA Classification Version 11.5 , February 2026\u003Cbr>See section 7.4 for further information on sub-groups. See section 7.3 for criteria for descriptors of the quality of MoA information. |  |  |\n| --- | --- | --- |\n| Main Group and Primary Site of Action | Sub-group, class or exemplifying Active Ingredient | Active Ingredients |\n| 1\u003Cbr>Acetylcholinesterase (AChE) inhibitors\u003Cbr>Nerve action\u003Cbr>{Strong evidence that action at this protein is responsible for insecticidal effects} | 1A\u003Cbr>Carbamates | Alanycarb, Aldicarb, Bendiocarb, Benfuracarb, Butocarboxim, Butoxycarboxim, Carbaryl, Carbofuran, Carbosulfan, Ethiofencarb, Fenobucarb, Formetanate, Furathiocarb, Isoprocarb, Methiocarb, Methomyl, Metolcarb, Oxamyl, Pirimicarb, Propoxur, Thiodicarb, Thiofanox, Triazamate,Trimethacarb, XMC, Xylylcarb |\n|  | 1B\u003Cbr>Organophosphates | Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos/ DDVP, Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O-(methoxyaminothiophosphoryl) salicylate, Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathionmethyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphosmethyl, Profenofos, Propetamphos, Prothiofos, Pyraclofos, Pyridaphenthion, Quinalphos, Sulfotep, Tebupirimfos, Temephos, Terbufos, Tetrachlorvinphos, Thiometon, Triazophos, Trichlorfon, Vamidothion |\n| 2\u003Cbr>GABA-gated chloride channel blockers | 2A\u003Cbr>Cyclodiene Organochlorines | Chlordane, Endosulfan |\n| Nerve action |  |  |\n| \u003Cbr>{Strong evidence that action at this protein is responsible for insecticidal effects} |  |  |\n|  | 2B\u003Cbr>Phenylpyrazoles (Fiproles) | Ethiprole, Fipronil |\n\n| IRAC MoA Classification Version 11.5 , February 2026\u003Cbr>See section 7.4 for further information on sub-groups. See section 7.3 for criteria for descriptors of the quality of MoA information. |  |  |\n| --- | --- | --- |\n| Main Group and Primary Site of Action | Sub-group, class or exemplifying Active Ingredient | Active Ingredients |\n| 3\u003Cbr>Sodium channel modulators\u003Cbr>Nerve action\u003Cbr>{Strong evidence that action at this protein is responsible for insecticidal effects} | 3A\u003Cbr>Pyrethroids\u003Cbr>Pyrethrins | Acrinathrin, Allethrin, d-cis-trans Allethrin, dtrans Allethrin, Bifenthrin, Bioallethrin, Bioallethrin S-cyclopentenyl isomer , Bioresmethrin, Cycloprothrin, Cyfluthrin, betaCyfluthrin, Cyhalothrin, lambda-Cyhalothrin, gamma-Cyhalothrin, Cypermethrin, alphaCypermethrin, beta-Cypermethrin, thetacypermethrin, zeta-Cypermethrin, Cyphenothrin ,(1R)-trans-isomers], Deltamethrin, Empenthrin (EZ)- (1R) -isomers], Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Permethrin, Phenothrin [(1R)-trans-isomer], Prallethrin, Pyrethrins (pyrethrum), Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(1R)-isomers], Tralomethrin, Transfluthrin, |\n|  | 3B\u003Cbr>DDT\u003Cbr>Methoxychlor | DDT\u003Cbr>Methoxychlor |\n| 4\u003Cbr>Nicotinic acetylcholine receptor (nAChR) competitive modulators\u003Cbr>Nerve action\u003Cbr>{Strong evidence that action atone or more of this class of protein is responsible for insecticidal effects} | 4A\u003Cbr>Neonicotinoids | Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid, Thiamethoxam, |\n|  | 4B\u003Cbr>Nicotine | Nicotine |\n|  | 4C\u003Cbr>Sulfoximines | Sulfoxaflor |\n|  | 4D\u003Cbr>Butenolides | Flupyradifurone |\n|  | 4E\u003Cbr>Mesoionics | Dicloromezotiaz, Fenmezoditiaz, Triflumezopyrim |\n|  | 4F\u003Cbr>Pyridylidenes | Flupyrimin |\n| 5\u003Cbr>Nicotinic acetylcholine receptor (nAChR) allosteric modulators – Site I\u003Cbr>Nerve action\u003Cbr>{Strong evidence that action atone or more of","cbCaiqGAVuFbyVrg","https://ap.wps.com/l/cbCaiqGAVuFbyVrg","pdf",1480259,1,42,"English","en",105,"# Main groups and primary site of action\n## Sub-groups and active ingredients\n## Evidence descriptors for targeted proteins","[{\"question\":\"What does IRAC MoA Classification Version 11.5 organize?\",\"answer\":\"It organizes insecticidal modes of action into main groups and sub-groups based on primary sites of action and representative active ingredients.\"},{\"question\":\"How are sub-groups represented in the tables?\",\"answer\":\"Each sub-group lists active ingredients (example compounds) associated with that mode of action class.\"},{\"question\":\"What guidance is provided for assessing MoA information quality?\",\"answer\":\"The document references criteria for descriptors of the quality of MoA information in section 7.3 and additional details on sub-groups in section 7.4.\"}]","IRAC MoA Classification - 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