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IQGAP3 expression in PC was assessed by immunohistochemistry and multiple datasets, followed by network pathway analysis and construction of a multigene signature (SigIQGAP3NW). The signature robustly predicts recurrence and poor prognosis across independent PC cohorts and 26 cancer types, and associates with mitosis-related genes, immune checkpoint evasion, Treg infiltration, and reduced response to immune checkpoint 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immune checkpoint blockade therapy?",{"text":122,"@type":114},"SigIQGAP3NW predicts cancer recurrence and poor prognosis, while RELT correlates with immune checkpoints and both SigIQGAP3NW and/or RELT predict resistance to immune checkpoint blockade 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Research  \njournal [homepage: www. elsevier. com/locate/jare](homepage: www. elsevier. com/locate/jare)  \nOriginal Article  \nIQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms  \nWenjuan Mei a,b,c,d, ⇑, Ying Dong b,c,d, Yan Gub,c,d, Anil Kapoor b,c,d, Xiaozeng Lin b,c,d, Yingying Sub,c,d, Sandra Vega Neirab,c,d, Damu Tang b,c,d, ⇑  \na Department of Nephrology, The First Affiliated Hospital of Nanchang University, Jiangxi, China  \nb Urological Cancer Center for Research and Innovation (UCCRI), St Joseph’s Hospital, Hamilton, ON L8N 4A6, Canada c Department of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada  \nd The Research Institute of St Joe’s Hamilton, St Joseph’s Hospital, Hamilton, ON L8N 4A6, Canada  \nh i g h l i g h t s  \n􀀁 IQGAP3 network (NW) regulates mitosis in prostate cancer (PC) and other cancers.  \n􀀁 IQGAP3 correlates with PLK1 and TOP2A expression in PC and other cancers.  \n􀀁 SigIQGAP3NW robustly predicts recurrence and poor prognosis in PC and other cancers.  \n􀀁 RELT significantly correlates with immune checkpoint in PC and across human cancers.  \n􀀁 SigQIGAP3NW and RELT predict cancer resistance to immune checkpoint blockage therapy.  \ng r a p h i c a l a b s t r a c t  \na r t i c l e i n f o  \nArticle history:  \nReceived 30 October 2022  \nRevised 12 December 2022 Accepted 15 January 2023  \nAvailable online 18 January 2023  \nKeywords: IQGAP3  \nProstate cancer Clinical relevance Prognostic prediction Overall survival  \nImmune checkpoint blockade therapy  \na b s t r a c t  \nIntroduction: IQGAP3 possesses oncogenic actions; its impact on prostate cancer (PC) remains unclear. Objective: We will investigate IQGAP30 s association with PC progression, key mechanisms, prognosis, and immune evasion.  \nMethods: IQGAP3 expression in PC was examined by immunohistochemistry and using multiple datasets. IQGAP3 network was analyzed for pathway alterations and used to construct a multigene signature (SigIQGAP3NW). SigIQGAP3NW was characterized using LNCaP cell-derived castration-resistant PCs (CRPCs), analyzed for prognostic value in 26 human cancer types, and studied for association with immune evasion.  \nResults: Increases in IQGAP3 expression associated with PC tumorigenesis, tumor grade, metastasis, and p53 mutation. IQGAP3 correlative genes were dominantly involved in mitosis. IQGAP3 correlated with PLK1 and TOP2A expression at Spearman correlation/R = 0.89 (p 􀀃 3.069e-169). Both correlations were enriched in advanced PCs and Taxane-treated CRPCs and occurred at high levels (R > 0.8) in multiple cancer types. SigIQGAP3NW effectively predicted cancer recurrence and poor prognosis in independent PC cohorts and across 26 cancer types. SigIQGAP3NW stratified PC recurrence after adjustment for age at diagnosis, grade, stage, and surgical margin. SigIQGAP3NW component genes were upregulated in PC, metastasis, LNCaP cell-produced CRPC, and showed an association with p53 mutation. SigIQGAP3NW  \nPeer review under responsibility of Cairo University.  \n⇑ Corresponding authors at: Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China (W. Mei). T3310, St. Joseph’s Hospital, 50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada (D. Tang).  \nE-mail [addresses:](addresses: wenjuanmei1986@163.com)[ wenjuanmei1986@163.com](addresses: wenjuanmei1986@163.com) (W. Mei), [damut@mcmaster.ca](damut@mcmaster.ca) (D. Tang).  \n[https://doi.org/10.1016/j.jare.2023.01.015](https://doi.org/10.1016/j.jare.2023.01.015)  \n2090-1232/􀀁 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.  \nThis is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nW. Mei, Y. Dong, Y. Gu et al. Journal of Advanced Research 54 (2023) 1","cbCait03MgtNDyBb","https://ap.wps.com/l/cbCait03MgtNDyBb","pdf",4610676,16,"English","# Introduction\n# Methods\n## Expression analysis and immunohistochemistry\n## Network analysis and multigene signature construction\n# Results\n## Association with tumor progression and p53 mutation\n## Correlation with PLK1 and TOP2A\n## Prognostic performance of SigIQGAP3NW\n## Links to immune evasion and checkpoint blockade response\n# Conclusions","[{\"question\":\"What was the study’s main objective regarding IQGAP3 and prostate cancer?\",\"answer\":\"To examine IQGAP3’s association with prostate cancer progression, key mechanisms, prognosis, and immune evasion.\"},{\"question\":\"How did the researchers evaluate IQGAP3 in prostate cancer?\",\"answer\":\"They analyzed IQGAP3 expression using immunohistochemistry and multiple datasets, then studied the IQGAP3 network for pathway alterations and built a multigene signature (SigIQGAP3NW).\"},{\"question\":\"What do SigIQGAP3NW and RELT indicate for prognosis and immune checkpoint blockade therapy?\",\"answer\":\"SigIQGAP3NW predicts cancer recurrence and poor prognosis, while RELT correlates with immune checkpoints and both SigIQGAP3NW and/or RELT predict resistance to immune checkpoint blockade therapy.\"}]","IQGAP3 is relevant to prostate cancer - A detailed presentation of potential pathomechanisms | PDF",1790230327]