[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426053-105":59,"doc-detail-426053-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","ipa-improves-muscle-function-and-reduces-bone-loss-in-aged-mice-and-modulates-lifespan-in-drosophila-melanogaster","IPA Improves Muscle Function and Reduces Bone Loss in Aged Mice and Modulates Lifespan in Drosophila melanogaster","","Aging is linked to disruptions in endogenous tryptophan metabolism that drive musculoskeletal decline. This study examines whether indole-3-propionic acid (IPA), a microbiota-derived tryptophan metabolite, improves musculoskeletal health in aged mice and influences lifespan in Drosophila melanogaster. IPA-treated aged mice show enhanced muscle performance and improved bone microarchitecture without changes in muscle fiber size. IPA also suppresses oxidative stress and senescence. In flies, lifespan increases are genotype- and sex-specific, supporting IPA as a potential therapeutic intervention for age-related decline.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ipa-improves-muscle-function-and-reduces-bone-loss-in-aged-mice-and-modulates-lifespan-in-drosophila-melanogaster/426053/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ipa-improves-muscle-function-and-reduces-bone-loss-in-aged-mice-and-modulates-lifespan-in-drosophila-melanogaster/426053.png","ImageObject",300,407,{"name":92,"@type":93},"Putri","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the study address in aging biology?","Question",{"text":112,"@type":113},"It addresses aging-associated alterations in tryptophan metabolism that contribute to musculoskeletal decline and reduced healthy lifespan.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does IPA affect muscle function in aged mice?",{"text":117,"@type":113},"IPA-treated aged mice exhibit enhanced muscle function, including improved grip strength and hang time.",{"name":119,"@type":110,"acceptedAnswer":120},"Does IPA change bone structure in aged mice, and how was it assessed?",{"text":121,"@type":113},"Yes. Histology and bone microCT analyses showed enhanced bone microarchitecture, while muscle fiber size remained unchanged.",{"name":123,"@type":110,"acceptedAnswer":124},"How is lifespan affected in Drosophila, and what determines the effect?",{"text":125,"@type":113},"Drosophila lifespan is significantly extended by IPA, but the lifespan effects depend on genotype and sex.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},426053,1790766987,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","1186 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3971  \nIPA IMPROVES MUSCLE FUNCTION AND REDUCES BONE LOSS IN AGED MICE AND MODULATE  \nLIFESPAN IN DROSOPHILA MELANOGASTER  \nSagar Vyavahare1, Ford Berger2, Shelton Swint3, Roger Zhong2, Marion Cooley4, Carlos Isales5, Jessica Hoffman2, and Sadanand Fulzele2, 1. Augusta University, Martinez, Georgia, United States, 2. Augusta University, Augusta, Georgia, United States, 3. College of Science and Mathematics, Augusta, Georgia, United States, 4. Dental College of Georgia, Augusta, Georgia, United States, 5. Augusta Universoty, Augusta, Georgia, United States  \nAging is associated with alterations in endogenous tryptophan (TRP) metabolism that contribute to musculoskeletal decline. In this study, we investigated the effects of the microbiota-derived tryptophan (TRP) metabolite, indole-3-propionic acid (IPA), on musculoskeletal health in aged mice. Additionally, we assessed the impact of IPA on the lifespan of the fruit fly, Drosophila melanogaster. Our findings revealed that IPA-treated aged mice exhibited enhanced muscle function (grip strength and hang time) . Histological and bone microCT analyses revealed no changes in muscle fiber size but enhanced bone microarchitecture. Furthermore, molecular studies have elucidated that IPA treatment prevents oxidative stress and reduces senescence, indicating improved cellular survival. Our Drosophila melanogaster longevity analysis revealed a significant extension of lifespan, but lifespan effects were genotype-and sex-specific. Collectively, our findings identify IPA as a promising microbiota-derived metabolite that improves musculoskeletal health and promotes longevity, highlighting its potential asa therapeutic intervention for age-related decline.","cbCaicPgzw0Prjrf","https://ap.wps.com/l/cbCaicPgzw0Prjrf","pdf",1042524,"English","# Abstract\n## Rationale and study focus\n## Effects in aged mice\n## Bone and cellular mechanisms\n## Lifespan effects in Drosophila","[{\"question\":\"What problem does the study address in aging biology?\",\"answer\":\"It addresses aging-associated alterations in tryptophan metabolism that contribute to musculoskeletal decline and reduced healthy lifespan.\"},{\"question\":\"How does IPA affect muscle function in aged mice?\",\"answer\":\"IPA-treated aged mice exhibit enhanced muscle function, including improved grip strength and hang time.\"},{\"question\":\"Does IPA change bone structure in aged mice, and how was it assessed?\",\"answer\":\"Yes. Histology and bone microCT analyses showed enhanced bone microarchitecture, while muscle fiber size remained unchanged.\"},{\"question\":\"How is lifespan affected in Drosophila, and what determines the effect?\",\"answer\":\"Drosophila lifespan is significantly extended by IPA, but the lifespan effects depend on genotype and sex.\"}]","IPA Improves Muscle Function and Reduces Bone Loss in Aged Mice and Modulates Lifespan in Drosophila melanogaster | PDF",1790639217]