[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443695-105":59,"doc-detail-443695-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ionomer-based-ion-sensitive-field-effect-transistor-for-lithium-ion-sensing","Ionomer-Based Ion-Sensitive Field-Effect Transistor for Lithium Ion Sensing","","Lithium detection is essential in medicine because lithium is used for treating bipolar disorder and requires regular monitoring. The study presents a simple ion-sensitive field-effect transistor approach to detect lithium in solution. Nafion 115 is conditioned to enable transport of Li+ from the electrolyte to a zinc oxide-based transistor. Measurements cover 10−2 to 10−7 M lithium. COMSOL modeling focuses on 10−2 M. The device achieves 2.85 mA/decade sensitivity and 77 μM detection limit.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ionomer-based-ion-sensitive-field-effect-transistor-for-lithium-ion-sensing/443695/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ionomer-based-ion-sensitive-field-effect-transistor-for-lithium-ion-sensing/443695.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does the device detect lithium ions in solution?","Question",{"text":112,"@type":113},"It uses an ionomer-based ISFET where Nafion 115 transports Li+ to a ZnO transistor channel, enabling an electrical response to lithium presence.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What lithium concentration range was tested?",{"text":117,"@type":113},"The study investigates lithium ion concentrations from 10−2 to 10−7 M.",{"name":119,"@type":110,"acceptedAnswer":120},"What performance metrics does the study report?",{"text":121,"@type":113},"The device shows 2.85 mA/decade sensitivity and a 77 μM detection limit.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443695,1790888953,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","This article is licensed under CC-BY 4.0   \n[http://pubs.acs.org/journal/acsodf](http://pubs.acs.org/journal/acsodf)  Article   \nIonomer-Based Ion-Sensitive Field-Effect Transistor for Lithium Ion Sensing  \nTuluhan Olcayto Colak, Mehmet Kurt, Ecenaz Yaman, Nurdan Demirci Sankir, * and Mehmet Sankir *  \n Cite This: ACS Omega 2025, 10, 58296−58305  \nRead Online  \n\n|  |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |  | *sı Supporting Information |\n\nABSTRACT: Lithium detection is critical in the medical field, as it is used for the treatment ofbipolar disorder. Here, we offer a simple method using an ion-sensitive field-effect transistor device prepared to detect the presence of lithium in a solution. The Nafion 115 membrane used in this study has been conditioned to allow the transport of lithium ions from the electrolyte to a zinc oxide-based transistor. The device was studied with lithium ion concentrations ranging between 10−2−10−7 M. It was modeled using the COMSOL Multiphysics program for 10−2 M. The device showed 2.85 mA/decade sensitivity and a detection limit of 77 μM.  \n■ INTRODUCTION  \nThrough its mood-stabilizing properties, lithium is the main treatment for bipolar disorder1,2 and other health problems3,4 and requires regular checking.5 There are a great number of studies throughout the literature on the detection of lithium ions (Table S1). Singh and Kumbhat6 presented an easy fabrication and sensing approach for an electrochemical sensorstrip that was functionalized with a 14-crown-4 ether-based ionophore. Another study was conducted by Gupta et al.,7 in which they developed a carbosiloxane dendrimer for the purpose of detecting lithium ions. Obare and Murphy8 have developed a lithium-selective variation of the dipyridophenazine (DPPZ) ligand, when bound to lithium ions, changes the color of its emission. Furthermore, thin films of LiMn2O4 have proven selective lithium detection by showing Li+ intercalation from aqueous solutions is both quick and reversible.9 Teixeira et al.10 investigated a graphite−epoxy electrode which was working within a molar range of 10−6 to 3.3 × 10−2.  \nHere, we present a system including an ionomer-based lithium-ion transporter and a nonenzymatic ISFET sensor built on an FTO substrate, using ZnO as a channel and Nafion 115 as a gate. The functionality of the device depends on the Nafion 115 cation exchange ionomer membrane, which serves as the Li+ transporter in ISFET systems and sensors during linear sweep measurements. Ionomer membranes, particularly perfluorosulfonic acid variants such as Nafion, may become crucial in ion-sensitive field-effect transistor (ISFET) applications due to their unique properties, including ionic conductivity, chemical stability, selective ion permeability, and the ability to serve as a supportive matrix or protective barrier. ZnO attracts attention due to its eco-friendly and  \nnontoxic properties, as it can be produced in a controlled manner with easy and cost-effective methods of thin films for various applications. 11−14 It has excellent electrical properties and has demonstrated significant potential in the development of various ZnO-based sensors and sensing platforms. 15−17 An advantage of these films is the ability to modify their properties by introducing a donor or acceptor impurity. 18−23 ZnO-based ISFET devices have been mostly used for pH sensing.17,24−26 However, a device in which ZnO and ionomer membranes are used together and lithium ions are determined, as in this study, has not been reported previously. Previously, all-solid-state two-electrode photosupercapacitors constructed by our group have used lithiated Nafion membranes as separators.27 There are quite a few studies on cation determination in the literature.28−31 However, the most fundamental disadvantages of these studies are that they either perform quantitative determination with enzymatic methods32−36 or, in the case","cbCaiu8C42ucwvQB","https://ap.wps.com/l/cbCaiu8C42ucwvQB","pdf",3995449,"English","# Abstract\n# Introduction\n## Motivation for lithium detection\n## Role of Nafion 115 and ZnO in ISFETs\n## Gaps in prior lithium-sensing approaches\n# Experimental Section\n## Preparation of device\n## Device structure and measurement concept","[{\"question\":\"How does the device detect lithium ions in solution?\",\"answer\":\"It uses an ionomer-based ISFET where Nafion 115 transports Li+ to a ZnO transistor channel, enabling an electrical response to lithium presence.\"},{\"question\":\"What lithium concentration range was tested?\",\"answer\":\"The study investigates lithium ion concentrations from 10−2 to 10−7 M.\"},{\"question\":\"What performance metrics does the study report?\",\"answer\":\"The device shows 2.85 mA/decade sensitivity and a 77 μM detection limit.\"}]","Ionomer-Based Ion-Sensitive Field-Effect Transistor for Lithium Ion Sensing | PDF",1790705018,25]