[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328287-105":59,"doc-detail-328287-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","investigation-of-miltefosine-model-membranes-interactions-at-the-molecular-level-for-two-different-ps-levels-modeling-cancer-cells-research","Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells - Research","","Miltefosine (MLT) is a broad-spectrum alkylphospholipid drug investigated here for its molecular effects on model membranes with different phosphatidylserine (PS) ratios, a marker linked to cancer stage and metastasis. The study analyzes membrane phase transition, lipid order, and membrane dynamics using DPPC/DPPS multilayer vesicles (3:1 and 1:1), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FTIR) spectroscopy. Results indicate MLT preferentially targets tumor-like membranes and its effect increases with higher anionic lipid content.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/investigation-of-miltefosine-model-membranes-interactions-at-the-molecular-level-for-two-different-ps-levels-modeling-cancer-cells-research/328287/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/investigation-of-miltefosine-model-membranes-interactions-at-the-molecular-level-for-two-different-ps-levels-modeling-cancer-cells-research/328287.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What research question does this study focus on?","Question",{"text":112,"@type":113},"It investigates how miltefosine affects model membranes at the molecular level under different phosphatidylserine (PS) ratios that mimic cancer-cell conditions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which experimental approaches were used to study miltefosine effects?",{"text":117,"@type":113},"The study uses DPPC/DPPS multilayer vesicles with two PS ratios, along with Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy to assess phase transition, order, and dynamics.",{"name":119,"@type":110,"acceptedAnswer":120},"How does changing PS ratio influence the observed effect of miltefosine?",{"text":121,"@type":113},"The findings indicate that the drug’s effect increases as anionic lipid content in the membrane increases, corresponding to higher PS levels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328287,1790178628,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Journal of Bioenergetics and Biomembranes (2024) 56:461–473  \n[https://doi.org/10.1007/s10863-024-10025-y](https://doi.org/10.1007/s10863-024-10025-y)  \nRESEARCH  \nInvestigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells  \nZüleyha Özçelik Çetinel1 · Duygu Bilge1  \nReceived: 1 April 2024 / Accepted: 26 May 2024 / Published online: 4 June 2024 © The Author(s) 2024  \nAbstract  \nMiltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various types of cancer. The most crucial feature of APLs is that they are thought to only kill cancerous cells without harming normal cells. However, the molecular mechanism of action of APLs is not completely understood. The increase in the phosphatidylserine (PS) ratio is a marker showing the stage of cancer and even metastasis. The goal of this research was to investigate the molecular effects of miltefosine at the molecular level in different PS ratios. The effects of MLTon membrane phase transition, membrane orders, and dynamics were studied using DPPC/DPPS (3:1) and DPPC/DPPS (1:1) multilayer (MLV) vesicles mimicking DPPS ratio variation, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared spectroscopy (FTIR) . Our findings indicate that miltefosine is evidence at the molecular level that it is directed towards the tumor cell and that the drug’s effect increases with the increase of anionic lipids in the membrane depending on the stage of cancer.  \nKeywords Fourier transformation infrared spectroscopy · Differential scanning calorimetry · Miltefosine · Dipalmitoyl phosphatidylserine level · Cancer  \nIntroduction  \nDisease and infection rates are steadily growing as the world’s population grows. Cancer has become a major cause of mortality globally among the different hazards to humanity (Ferlay et al. 2010; Pugazhendhi et al. 2018) . 90% of cancer fatalities are caused by metastasis (Veiseh et al. 2011), and it is expected that 13 million people would die from cancer worldwide by 2030 (Pugazhendhi et al. 2018; Vyas et al. 2012) . Traditional radiological and histological tests can be used to treat cancer, although chemotherapy, radiation, and surgery are the most often used cancer therapies. Treatment seeks to eliminate malignant cells while avoiding damaging healthy cells (Pugazhendhi et al. 2018; Singhal et al. 2010) .  \nMiltefosine, edelfosine, and perifosine are synthetic anticancer alkylphospholipids (APLs) that are structurally  \n􀀍 Duygu Bilge [duygu.bilge@ege.edu.tr](duygu.bilge@ege.edu.tr)  \n1 Department of Physics, Faculty of Science, Ege University, Bornova, Izmir 35100, Turkey  \nsimilar to lipids and are expected to have effects on cellular membranes instead of DNA. APLs involve a lengthy hydrocarbon chain that is easily incorporated into lipid bilayer membranes, yet they are resistant to catabolic breakdown (Van Blitterswijk and Verheij 2008) . As a result, APLs are thought to cumulate in cell membranes and disrupt the metabolism of normal lipid and signal transmission.  \nThis activity, which generally results in apoptosis, is reported to be particularly successful in metabolically active, proliferating cells like tumor cell, but asymptomatic in healthy cells; that is, they have no effect on normal cells. APLs can show promising results in combination with traditional cancer treatments. For instance, it is known that ALPs make cancer cells more sensitive to radiotherapy both in vitro and in vivo (Van Blitterswijk and Verheij 2008; Spronget al. 2001; Hilgard et al. 1997) .  \nMiltefosine (MLT) was one of the first alkylphospholipids to enter clinical trials (Unger et al. 1988, 1990) . This drug is a synthetic phospholipid derivative noted for its resemblance to lecithin, the main component of the cell membrane. It is the first antitumor lipid to be utilized in clinical studies, specifically topical medication for breast cancer skin metas","cbCaiama30bmN9Hj","https://ap.wps.com/l/cbCaiama30bmN9Hj","pdf",4277906,13,"English","# Abstract\n# Introduction\n## Background on cancer incidence and metastasis\n## Alkylphospholipids and membrane-targeting rationale\n## Miltefosine in clinical research and prior findings\n# Methods and study design (model membranes and measurements)\n# Results and molecular-level conclusions","[{\"question\":\"What research question does this study focus on?\",\"answer\":\"It investigates how miltefosine affects model membranes at the molecular level under different phosphatidylserine (PS) ratios that mimic cancer-cell conditions.\"},{\"question\":\"Which experimental approaches were used to study miltefosine effects?\",\"answer\":\"The study uses DPPC/DPPS multilayer vesicles with two PS ratios, along with Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR) spectroscopy to assess phase transition, order, and dynamics.\"},{\"question\":\"How does changing PS ratio influence the observed effect of miltefosine?\",\"answer\":\"The findings indicate that the drug’s effect increases as anionic lipid content in the membrane increases, corresponding to higher PS levels.\"}]","Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells - Research | PDF",1789979180,33]