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Beyond oncology, Chk2 targeting is discussed for hepatitis C virus replication and neurodegenerative contexts such as ALS, where DNA damage contributes to disease.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/investigation-into-the-neuroprotective-and-therapeutic-potential-of-plant-derived-chk2-inhibitors/331019/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/investigation-into-the-neuroprotective-and-therapeutic-potential-of-plant-derived-chk2-inhibitors/331019.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-14","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is checkpoint kinase 2 (Chk2) and why is it important?","Question",{"text":63,"@type":64},"Chk2 is a cell-cycle checkpoint kinase that regulates DNA repair, cell-cycle arrest, and apoptosis. 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Investigation into the Neuroprotective and Therapeutic Potential of Plant-Derived Chk2 Inhibitors. Int. J. Mol. Sci. 2024, 25, 7725. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25147725  \nAcademic Editors: Karolina Hoppe and Magdalena Wo´zniak  \nReceived: 19 May 2024  \nRevised: 9 July 2024  \nAccepted: 11 July 2024  \nPublished: 15 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland; [monika.kisielewska@student.umw.edu.pl](monika.kisielewska@student.umw.edu.pl) (M.K.); [michal.filipski@student.umw.edu.pl](michal.filipski@student.umw.edu.pl) (M.F.); [kamil.sebastianka@student.umw.edu.pl](kamil.sebastianka@student.umw.edu.pl) (K.S.); [dobrawa.karas@student.umw.edu.pl](dobrawa.karas@student.umw.edu.pl) (D.K.); [klaudia.molik@student.umw.edu.pl](klaudia.molik@student.umw.edu.pl) (K.M.)  \n2 Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland  \n* Correspondence: [anna.choromanska@umw.edu.pl](anna.choromanska@umw.edu.pl)  \nAbstract: Nature provides us with a rich source of compounds with a wide range of applications, including the creation of innovative drugs. Despite advancements in chemically synthesized therapeutics, natural compounds are increasingly significant, especially in cancer treatment, a leading cause of death globally. One promising approach involves the use of natural inhibitors of checkpoint kinase 2 (Chk2), a critical regulator of DNA repair, cell cycle arrest, and apoptosis. Chk2’s activation in response to DNA damage can lead to apoptosis or DNA repair, influencing glycolysis and mitochondrial function. In cancer therapy, inhibiting Chk2 can disrupt DNA repair and cell cycle progression, promoting cancer cell death and enhancing the efficacy of radiotherapy and chemotherapy. Additionally, Chk2 inhibitors can safeguard non-cancerous cells during these treatments by inhibiting p53-dependent apoptosis. Beyond oncology, Chk2 inhibition shows potential in treating hepatitis C virus (HCV) infections, as the virus relies on Chk2 for RNA replication in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), in which DNA damage plays a crucial role. Plant-derived Chk2 inhibitors, such as artemetin, rhamnetin, and curcumin, offer a promising future for treating various diseases with potentially milder side effects and broader metabolic impacts compared to conventional therapies. The review aims to underscore the immense potential of natural Chk2 inhibitors in various therapeutic contexts, particularly in oncology and the treatment of other diseases involving DNA damage and repair mechanisms. These natural Chk2 inhibitors hold significant promise for revolutionizing the landscape of cancer treatment and other diseases. Further research into these compounds could lead to the development of innovative therapies that offer hope for the future with fewer side effects and enhanced efficacy.  \nKeywords: plant-derived inhibitors; innovative drugs; cancer treatment; checkpoint kinase 2; DNA repair; apoptosis; cell cycle arrest; checkpoint kinase 2 inhibitors; neurodegenerative diseases; amyotrophic lateral sclerosis  \n1. Introduction and Background  \nNature is an in","cbCairMFwIo4i8Pu","https://ap.wps.com/l/cbCairMFwIo4i8Pu","pdf",639046,13,"English","# 1. Introduction and Background\n## Nature-derived compounds and therapeutic relevance\n## Chk2 functions in DNA repair, cell-cycle control, and apoptosis\n## Impact of Chk2 inhibition on cancer and therapeutic pathways","[{\"question\":\"What is checkpoint kinase 2 (Chk2) and why is it important?\",\"answer\":\"Chk2 is a cell-cycle checkpoint kinase that regulates DNA repair, cell-cycle arrest, and apoptosis. It responds to DNA damage by activating pathways that can lead to either apoptosis or repair.\"},{\"question\":\"How can plant-derived Chk2 inhibitors support cancer therapy?\",\"answer\":\"Inhibiting Chk2 can disrupt DNA repair and checkpoint progression, promoting cancer cell death. It may also enhance the effectiveness of radiotherapy and chemotherapy while targeting DNA damage response pathways.\"},{\"question\":\"Are Chk2 inhibitors being considered for diseases beyond cancer?\",\"answer\":\"Yes. The review discusses potential roles in hepatitis C virus infection, since the virus uses Chk2-related mechanisms for RNA replication, and in neurodegenerative diseases like ALS where DNA damage is implicated.\"}]","Investigation into the Neuroprotective and Therapeutic Potential of Plant-Derived Chk2 Inhibitors | PDF",1789991115,33]