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Accumulating evidence indicates that miRNAs can promote or suppress tumorigenesis by controlling specific target genes or signaling pathways, and miRNAs are implicated in carcinoma development. miR-409-3p is dysregulated across many malignant cancers and supports key cellular processes including proliferation, apoptosis, migration, invasion, autophagy, angiogenesis, and glycolysis. It is also proposed as a non-invasive biomarker. Mechanistic understanding of miR-409-3p-driven tumor progression may advance miR-409-3p-based targeted therapies and inform cancer diagnosis and treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/investigating-the-molecular-mechanisms-of-microrna-409-3p-in-tumor-progression-towards-targeted-therapeutics/330775/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/investigating-the-molecular-mechanisms-of-microrna-409-3p-in-tumor-progression-towards-targeted-therapeutics/330775.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are microRNAs and how do they regulate gene expression in cancer?","Question",{"text":112,"@type":113},"MicroRNAs are non-coding RNAs that regulate gene expression post-transcriptionally by recognizing target mRNA regions, affecting cleavage or translation. They can modulate tumor-promoting or tumor-suppressing pathways depending on their targets.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles does miR-409-3p play in tumor progression?",{"text":117,"@type":113},"miR-409-3p is dysregulated in multiple malignant cancers and contributes to key processes such as cell proliferation, apoptosis, migration, invasion, autophagy, angiogenesis, and glycolysis. The review emphasizes its fundamental involvement in these cellular functions.",{"name":119,"@type":110,"acceptedAnswer":120},"How could miR-409-3p be used clinically?",{"text":121,"@type":113},"The review discusses miR-409-3p as an expected non-invasive biomarker. It also highlights that understanding miR-409-3p-mediated mechanisms may support the development of miR-409-3p-based targeted therapies and improve cancer diagnosis and treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330775,1790828432,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","INTERNATIONAL JOURNAL OF ONCOLOGY 65: 67, 2024  \nInvestigating the molecular mechanisms of microRNA‑409‑3pin tumor progression: Towards targeted therapeutics (Review)  \nWENJIE XIE 1 , ZHICHAO WANG 1 , JUNKE WANG2 , XIU WANG3 and HONGZAI GUAN 1  \n1Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China; 2Department of Cardiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China; 3Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China  \nReceived December 14, 2023; Accepted May 2, 2024  \nDOI: 10.3892/ijo.2024.5655  \nAbstract. MicroRNAs (miRNAs) are a group of non‑coding RNAsthatexertmasterregulatoryfunctionsinpost‑transcriptional gene expression. Accumulating evidence shows that miRNAs can either promote or suppress tumorigenesis by regulating different target genes or pathways and may be involved in the occurrence of carcinoma. miR‑409‑3p is dysregulated in a variety of malig‑ nant cancers. It plays a fundamental role in numerous cellular biological processes, such as cell proliferation, apoptosis, migra‑ tion, invasion, autophagy, angiogenesis and glycolysis. In addition, studies have shown that miR‑409‑3p is expected to become anon‑invasive biomarker. Identifying the molecular mechanisms underlying miR‑409‑3p‑mediated tumor progression will help investigate miR‑409‑3p‑based targeted therapy for human cancers. The present review comprehensively summarized the recently published literature on miR‑409‑3p, with a focus on the regulation and function of miR‑409‑3p in various types of cancer, and discussed the clinical implications of miR‑409‑3p, providing new insight for the diagnosis and treatment of cancers.  \nContents  \n1. Introduction  \n2. Aberrant expression of miR‑409‑3p in cancers  \n3. Clinical applications  \n4. Biological roles of miR‑409‑3p in cancers in vitro  \n5. Biological roles of miR‑409‑3p in cancers in vivo  \n6. MiR‑409‑3p‑related signaling pathways  \n7. Discussion  \n1. Introduction  \nMicroRNAs (miRNAs/miRs) are a type of naturally occurring non‑coding single‑stranded RNA that range between 19 and 22 nucleotides in length. They are involved in the post‑tran‑ scriptional regulation of gene by effectively recognizing the target genes' 3'‑untranslated region (UTR) and cleaving  \nCorrespondence to: Dr Hongzai Guan, Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, Shandong 266000, P.R. China  \nE‑mail: [guanhongzai@qdu.edu.cn](guanhongzai@qdu.edu.cn)  \nAbbreviations: miRNA/miR, microRNA; UTR, untranslated region; NSCLC, non‑small cell lung cancer; BC, breast cancer; CC, cervical cancer; GC, gastric cancer; CRC, colorectal cancer; OC, ovarian cancer; ccRCC, renal cell carcinoma; BCa, bladder cancer; PTC, papillary thyroid cancer; PC, pancreatic cancer; BTC, biliary tract cancer; DLBCL, diffuse large B‑cell lymphoma; AML, acute myeloid leukemia; NPC, nasopharyngeal carcinoma; TSCC, tonguesquamous cell carcinoma; PCa, prostate cancer; HCC, hepatocellular carcinoma; lncRNA, lncRNA; circRNA, circular RNA; LUAD, lung adenocarcinoma; CIRT, carbon ion radiotherapy; MET, MET proto‑oncogene, receptor tyrosine kinase; SPIN1, spindlin1; ZB1‑AS1, zinc finger E‑box binding homeobox 1 antisense 1; ceRNA, competing endogenous RNA; HK2, hexokinase 2; LDHA, lactate dehydrogenase A; DUXAP8, double homeobox Apseudogene 8; SOD1, superoxide dismutase 1; CBR3‑AS1, CBR3 antisense RNA 1; AQP4, aquaporin4; AKT1, AKT serine/threonine kinase 1; circTRIM28, circular RNA tripartite motif‑containing 28; HMGA2, high mobility group AT‑hook 2; ATF1, activating transcription factor 1; circFAT1, circular RNA FAT atypical  \ncadherin 1; CDK8, cyclin‑dependent kinase 8; SLC7A11, solute carrier family 7 membrane 11; ELF2, E74‑like factor 2; IGFBP3, insulin‑like growth factor binding protein 3; PHF10, PHD finger protein","cbCaiqSGgZ3JgsDm","https://ap.wps.com/l/cbCaiqSGgZ3JgsDm","pdf",2156321,"English","# Introduction\n# Aberrant expression of miR-409-3p in cancers\n# Clinical applications\n# Biological roles of miR-409-3p in cancers in vitro\n# Biological roles of miR-409-3p in cancers in vivo\n# MiR-409-3p-related signaling pathways\n# Discussion","[{\"question\":\"What are microRNAs and how do they regulate gene expression in cancer?\",\"answer\":\"MicroRNAs are non-coding RNAs that regulate gene expression post-transcriptionally by recognizing target mRNA regions, affecting cleavage or translation. They can modulate tumor-promoting or tumor-suppressing pathways depending on their targets.\"},{\"question\":\"What roles does miR-409-3p play in tumor progression?\",\"answer\":\"miR-409-3p is dysregulated in multiple malignant cancers and contributes to key processes such as cell proliferation, apoptosis, migration, invasion, autophagy, angiogenesis, and glycolysis. The review emphasizes its fundamental involvement in these cellular functions.\"},{\"question\":\"How could miR-409-3p be used clinically?\",\"answer\":\"The review discusses miR-409-3p as an expected non-invasive biomarker. It also highlights that understanding miR-409-3p-mediated mechanisms may support the development of miR-409-3p-based targeted therapies and improve cancer diagnosis and treatment.\"}]","Investigating the molecular mechanisms of microRNA-409-3p in tumor progression - Towards targeted therapeutics | PDF",1789990047,76]