[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333867-105":59,"doc-detail-333867-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","investigating-the-impact-of-clinical-and-genetic-factors-on-the-postsurgery-prognosis-of-sinonasal-squamous-cell-carcinoma","Investigating the impact of clinical and genetic factors on the postsurgery prognosis of sinonasal squamous cell carcinoma","","Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer whose progression drivers, especially genetic influences, remain insufficiently clarified. A retrospective cohort of 219 SNSCC patients was analyzed to identify clinical predictors of prognosis, while a large literature-derived dataset was mined to uncover genetic factors. Clear operative margins, nasal cavity origin, and earlier T-stage showed markedly improved overall survival and reduced recurrence risk. The study also highlights 53 associated genes and enrichments in KEGG pathways and Gene Ontology terms, suggesting pathways affecting growth, apoptosis, and oncogenic signaling.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/investigating-the-impact-of-clinical-and-genetic-factors-on-the-postsurgery-prognosis-of-sinonasal-squamous-cell-carcinoma/333867/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/investigating-the-impact-of-clinical-and-genetic-factors-on-the-postsurgery-prognosis-of-sinonasal-squamous-cell-carcinoma/333867.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What clinical factors were associated with SNSCC prognosis after surgery?","Question",{"text":112,"@type":113},"Clear operative margins, nasal cavity origin, and earlier T-stage (T1-2) were linked to better overall survival and lower recurrence risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were genetic factors identified in relation to SNSCC progression?",{"text":117,"@type":113},"Genetic factors were uncovered by mining a large literature dataset, followed by constructing SNSCC prognosis pathways and performing gene set enrichment analysis (GSEA).",{"name":119,"@type":110,"acceptedAnswer":120},"Which biological processes or pathways were implicated by the identified genes?",{"text":121,"@type":113},"The associated genes and enrichments in KEGG pathways and Gene Ontology terms suggest effects on cell growth, apoptosis, and oncogenic signaling pathways.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333867,1790068919,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nInvestigating the impact of clinical and genetic factors on the postsurgery prognosis of sinonasalsquamous cell carcinoma  \nMeng Lian1􀀍, Boxuan Han1, Jiaming Chen1, Xixi Shen1, Yanming Zhao1, Qian Shi1, Ling Feng1, Shizhi He1, Hongzhi Ma1, Lizhen Hou1, Qi Zhong1, Hongbao Cao2 & Jugao Fang1􀀍  \nSinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA) . Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value \u003C 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. Our study suggests that three clinical parameters (operative margin type, primary tumor site, and T-stage) and 14 genetic factors may influence SNSCC prognosis post-surgery. These findings deepen our understanding ofSNSCC and offer potential avenues to enhance its treatment and outcomes.  \nKeywords SNSCC, Overall survival, Recurrence-free survival, Genetic factor, Prognosis analysis  \nThe malignancy of malignant tumors in the nasal and sinus regions is notably elevated, with a global incidence rate ranging from 0.2 to 0.8% of all malignant tumors, and comprising approximately 3% of malignancies in the upper respiratory tract1. Within this category, sinonasal squamous cell carcinoma (SNSCC) stands out as the most prevalent histological subtype. SNSCC primarily originates from the mucosal lining of the nasal cavity and paranasal sinuses, the air-filled spaces adjacent to the nose. While relatively uncommon, this malignancy is characterized by its aggressive nature2.  \nThe precise etiology of SNSCC may not always be definitively established, yet it is frequently linked to risk factors such as occupational exposure to specific hazards (e.g., wood dust, nickel, and formaldehyde), tobacco usage, and the presence of chronic sinusitis3–5. Typical manifestations encompass nasal congestion, epistaxis, facial discomfort, and alterations in olfactory perception. The diagnostic process typically entails imaging modalities such as CT scans and MRI, along with confirmatory biopsy procedures2.  \nTreatment modalities of SNSCC can encompass a combination of surgical procedures, radiation therapy, and chemotherapy. Presently, the National Comprehensive Cancer Network (NCCN) guidelines endorse holistic treatment approaches that integrate surgery with radiotherapy and chemotherapy6,7. The primary objective of surgical intervention is the complete eradication of the tumor. Over the years, head and neck surgeons have been actively investigating surgical treatments, with particular emphasis in the last decade on the advancementsin minimally invasive surgery and early screening techniques, which have led to gradual modifications in  \n1Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. 2School of Sy","cbCaimM3ut7bLEKB","https://ap.wps.com/l/cbCaimM3ut7bLEKB","pdf",3747147,12,"English","# Materials and methods\n## Participants for clinical data collection","[{\"question\":\"What clinical factors were associated with SNSCC prognosis after surgery?\",\"answer\":\"Clear operative margins, nasal cavity origin, and earlier T-stage (T1-2) were linked to better overall survival and lower recurrence risk.\"},{\"question\":\"How were genetic factors identified in relation to SNSCC progression?\",\"answer\":\"Genetic factors were uncovered by mining a large literature dataset, followed by constructing SNSCC prognosis pathways and performing gene set enrichment analysis (GSEA).\"},{\"question\":\"Which biological processes or pathways were implicated by the identified genes?\",\"answer\":\"The associated genes and enrichments in KEGG pathways and Gene Ontology terms suggest effects on cell growth, apoptosis, and oncogenic signaling pathways.\"}]","Investigating the impact of clinical and genetic factors on the postsurgery prognosis of sinonasal squamous cell carcinoma | PDF",1790004377]