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This review explores the interplay between intratumoral microbiota, tumor metabolism, and major types of GI cancers, summarizing recent studies and elucidating their clinical implications and future directions. Altered microbial signatures influence tumor progression, immune responses, and treatment outcomes. Dysbiosis-driven metabolic shifts in glycolysis, fatty acids, and amino acids contribute to cancer development and therapeutic resistance. Integrating molecular mechanisms and potential biomarkers may improve prognostic power and support microbiota-targeted precision oncology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/intratumoral-microbiota-metabolic-influences-and-biomarker-potential-in-gastrointestinal-cancer/331217/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/intratumoral-microbiota-metabolic-influences-and-biomarker-potential-in-gastrointestinal-cancer/331217.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does intratumoral microbiota refer to in GI cancers?","Question",{"text":112,"@type":113},"Intratumoral microbiota refers to a diverse community of microorganisms residing within tumor tissues, including bacteria, viruses, fungi, and archaea.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is tumor metabolism linked to GI cancer progression?",{"text":117,"@type":113},"Tumor metabolism involves altered energy production and nutrient utilization, including metabolic reprogramming such as aerobic glycolysis (Warburg effect), which helps sustain proliferation and adapt to the tumor microenvironment.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are intratumoral microbiota composition and biomarkers clinically important?",{"text":121,"@type":113},"Altered microbial signatures can affect progression, immune responses, and treatment outcomes, and integrating molecular mechanisms with microbiota-related biomarkers may improve prognostic significance and guide microbiota-mediated therapeutic opportunities.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331217,1790126057,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","biomolecules  \nReview  \nIntratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer  \nXueyuan Bi 1, Jihan Wang 2 and Cuicui Liu 3, *  \nCitation: Bi, X.; Wang, J.; Liu, C.  \nIntratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer. Biomolecules 2024, 14, 917. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/biom14080917](10.3390/biom14080917)  \nAcademic Editors: Anika Wagner and Wei Zhong  \nReceived: 10 July 2024  \nRevised: 21 July 2024  \nAccepted: 25 July 2024  \nPublished: 27 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Pharmacy, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China  \n2 Institute of Medical Research, Northwestern Polytechnical University, Xi’an 710072, China; [jihanwang@nwpu.edu.cn](jihanwang@nwpu.edu.cn)  \n3 Department of Science and Education, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China  \n* Correspondence: [cliu_honghui@126.com](cliu_honghui@126.com)  \nAbstract: Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores the interplay between intratumoral microbiota, tumor metabolism, and major types of GI cancers (including esophageal, gastric, liver, pancreatic, and colorectal cancers), summarizing recent studies and elucidating their clinical implications and future directions. Recent research revealed altered microbial signatures within GI tumors, impacting tumor progression, immune responses, and treatment outcomes. Dysbiosis-induced alterations in tumor metabolism, including glycolysis, fatty acid metabolism, and amino acid metabolism, play critical roles in cancer progression and therapeutic resistance. The integration of molecular mechanisms and potential biomarkers into this understanding further enhances the prognostic significance of intratumoral microbiota composition and therapeutic opportunities targeting microbiota-mediated tumor metabolism. Despite advancements, challenges remain in understanding the dynamic interactions within the tumor microenvironment (TME) . Future research directions, including advanced omics technologies and prospective clinical studies, offer promising avenues for precision oncology and personalized treatment interventionsin GI cancer. Overall, integrating microbiota-based approaches and molecular biomarkers into GI cancer management holds promise for improving patient outcomes and survival.  \nKeywords: intratumoral microbiota; gastrointestinal cancer; microbial biomarkers; tumor metabolism; tumor microenvironment  \n1. Introduction  \nGastrointestinal (GI) cancers encompass a diverse group of malignancies affecting the digestive system, mainly including the esophagus, stomach, liver, pancreas, colon, and rectum (colorectum) [1–3] . These cancers collectively pose a significant global health burden, representing a leading cause of cancer-related morbidity and mortality worldwide. Each type of GI cancer presents distinct challenges in terms of diagnosis, treatment, and prognosis. For instance, colorectal cancer (CRC) is one of the most common GI malignancies, with risk factors including age, family history, dietary habits, and inflammatory bowel diseases (IBDs) [4] . On the other hand, pancreatic cancer (PCA) often presents at an advanced stage, leading to poor prognosis and limited treatment options [5] . Despite advancements in screening, early detection, and treatment modalities such as surgery, chemotherapy, radiation therapy, and targeted therapy, GI cancers remain ","cbCaibOKD0zcckas","https://ap.wps.com/l/cbCaibOKD0zcckas","pdf",1162303,"English","# Introduction\n## Intratumoral microbiota and tumor biology\n## Tumor metabolism and microenvironment","[{\"question\":\"What does intratumoral microbiota refer to in GI cancers?\",\"answer\":\"Intratumoral microbiota refers to a diverse community of microorganisms residing within tumor tissues, including bacteria, viruses, fungi, and archaea.\"},{\"question\":\"How is tumor metabolism linked to GI cancer progression?\",\"answer\":\"Tumor metabolism involves altered energy production and nutrient utilization, including metabolic reprogramming such as aerobic glycolysis (Warburg effect), which helps sustain proliferation and adapt to the tumor microenvironment.\"},{\"question\":\"Why are intratumoral microbiota composition and biomarkers clinically important?\",\"answer\":\"Altered microbial signatures can affect progression, immune responses, and treatment outcomes, and integrating molecular mechanisms with microbiota-related biomarkers may improve prognostic significance and guide microbiota-mediated therapeutic opportunities.\"}]","Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer | PDF",1789992254,48]