[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-337596-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-337596-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","intratumoral-metastasis-of-sigmoid-colon-cancer-to-chromophobe-renal-cell-carcinoma-a-case-report","Intratumoral metastasis of sigmoid colon cancer to chromophobe renal cell carcinoma - a case report","","Extremely rare intratumoral metastasis from sigmoid colon cancer to chromophobe renal cell carcinoma is reported. A 71-year-old woman with lung metastasis underwent sigmoid colon resection and later surveillance of a left renal tumor found on contrast-enhanced CT. Two years afterward, the renal lesion enlarged and laparoscopic partial nephrectomy was performed, revealing chromophobe RCC harboring colon cancer metastasis. Adjuvant bevacizumab plus SOX was initiated, then changed to bevacizumab plus S-1 due to severe toxicity, and chemotherapy was discontinued by request; subsequent CT showed no renal recurrence but progressive lung and bone metastases, leading to palliative care.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/intratumoral-metastasis-of-sigmoid-colon-cancer-to-chromophobe-renal-cell-carcinoma-a-case-report/337596/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/intratumoral-metastasis-of-sigmoid-colon-cancer-to-chromophobe-renal-cell-carcinoma-a-case-report/337596.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the key diagnosis in this case?","Question",{"text":63,"@type":64},"The renal tumor was chromophobe renal cell carcinoma with intratumoral metastasis of sigmoid colon cancer located at the tumor center.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the left renal tumor initially managed?",{"text":68,"@type":64},"After sigmoid colon resection, preoperative CT detected a left renal tumor, but colon surgery was prioritized and the renal lesion was placed under observation.",{"name":70,"@type":61,"acceptedAnswer":71},"Why was adjuvant chemotherapy stopped?",{"text":72,"@type":64},"Severe chemotherapy-induced fatigue and nausea led to switching regimens, and the patient’s nausea did not improve; postoperative adjuvant chemotherapy was discontinued at the patient’s request four months after partial nephrectomy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337596,1790053595,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","International Cancer Conference Journal (2024) 13:134–138  \n[https://doi.org/10.1007/s13691-023-00651-5](https://doi.org/10.1007/s13691-023-00651-5)  \nIntratumoral metastasis ofsigmoid colon cancer to chromophobe renal cell carcinoma: a case report  \nSuzuna Sakai1 · Kojiro Ohba2 · Kazunari Migita3 · Ichiro Sekine4 · Yasuto Yamazaki1  \nReceived: 22 October 2023 / Accepted: 24 December 2023 / Published online: 3 February 2024 © The Author(s) 2024  \nAbstract  \nWe herein report an extremely rare case of intratumoral metastasis of colon cancer to chromophobe renal cell carcinoma. A 71-year-old woman was diagnosed with lung metastasis of sigmoid colon cancer and underwent sigmoid colon resection with D3 lymph node dissection. Preoperative contrast-enhanced computed tomography (CT) revealed a left renal tumor; however, colon resection was prioritized, and the renal tumor was placed under observation. Two years later, CT revealed enlargement of the left renal tumor, and laparoscopic partial left nephrectomy was performed 1 month later. Histopathologic examination showed that the resected renal tumor was a chromophobe renal cell carcinoma with intratumoral metastasis of colon cancer to the renal tumor center, and adjuvant chemotherapy with bevacizumab plus SOX (L-OHP + S-1) was initiated. Because of severe chemotherapy-induced fatigue and nausea, the patient was switched to bevacizumab + S-1. However, the patient’s nausea did not improve after this change, and postoperative adjuvant chemotherapy was discontinued at the patient’s request 4 months after the partial nephrectomy. Two months after discontinuation of chemotherapy, CT showed no renal recurrence; however, increased lung metastases and a new bone metastasis in the left sciatic bone were observed. Palliative treatment was then initiated because of severe adverse events that made it difficult to continue treatment. In patients who have multiple cancers and an increase in renal tumor size, the possibility of intratumoral metastasis to the renal tumor should be considered.  \nKeywords Renal cell carcinoma · Metastasis · Colon cancer · Intratumoral metastasis  \nIntroduction  \nIntratumoral metastasis is an uncommon occurrence characterized by the spread of malignant cells from one tumor to within another malignant tumor located outside the primary organ [1]. The kidney is reportedly the most common recipient organ for intratumoral metastasis, and most recipient tumors are clear cell carcinomas; there are few reports of intratumoral metastasis to chromophobe renal cell carcinoma [2, 3] . We herein report a very unusual case of intratumoral  \n* Kojiro Ohba [ohba-k@nagasaki-u.ac.jp](ohba-k@nagasaki-u.ac.jp)  \n1 Department of Urology, Kouseikai Hospital, Nagasaki, Japan  \n2 Department of Urology and Renal Transplantation, Nagasaki University Hospital, Nagasaki, Japan  \n3 Department of Surgery, Kouseikai Hospital, Nagasaki, Japan  \n4 Department of Pathology, Kouseikai Hospital, Nagasaki, Japan  \nmetastasis of sigmoid colon cancer to chromophobe renal cell carcinoma.  \nCase report  \nA 71-year-old woman was diagnosed with sigmoid colon cancer with lung metastasis. One month after diagnosis, she underwent sigmoid colon resection with D3 lymph node dissection. Preoperative contrast-enhanced computed tomography (CT) had revealed a tumor in the left kidney, but this tumor was not prioritized for treatment. The definitive diagnosis was sigmoid colon cancer (pT3N0M1), and the patient received chemotherapy with mFOLFOX6 (oxaliplatin [85 mg/m2], levofolinate [200 mg/m2], and fluorouracil [400 mg/m2 bolus followed by 2400 mg/m2 over 12 cycles]) plus bevacizumab (Avastin; Genentech, South San Francisco, CA, USA [5 mg/kg]) . The patient achieved a partial response with chemotherapy; however, the chemotherapy was discontinued at the patient’s request after two cycles. One year after surgery, she was diagnosed with advanced  \nlung metastasis and underwent robot-assisted right upper lobectomy in another h","cbCaid9gLLoOogmb","https://ap.wps.com/l/cbCaid9gLLoOogmb","pdf",1066770,"English","# Abstract\n# Introduction\n# Case report\n## Patient timeline and treatment\n## Imaging and laboratory findings\n## Surgery and pathology","[{\"question\":\"What was the key diagnosis in this case?\",\"answer\":\"The renal tumor was chromophobe renal cell carcinoma with intratumoral metastasis of sigmoid colon cancer located at the tumor center.\"},{\"question\":\"How was the left renal tumor initially managed?\",\"answer\":\"After sigmoid colon resection, preoperative CT detected a left renal tumor, but colon surgery was prioritized and the renal lesion was placed under observation.\"},{\"question\":\"Why was adjuvant chemotherapy stopped?\",\"answer\":\"Severe chemotherapy-induced fatigue and nausea led to switching regimens, and the patient’s nausea did not improve; postoperative adjuvant chemotherapy was discontinued at the patient’s request four months after partial nephrectomy.\"}]","Intratumoral metastasis of sigmoid colon cancer to chromophobe renal cell carcinoma - a case report | PDF",1790019724,13]