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Fusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily from the oral cavity, has emerged as an oncobacterium linked to pancreatic cancer progression and prognosis. It contributes via immune modulation, virulence factors, effects on cell proliferation, metabolite interactions, DNA damage, and epithelial–mesenchymal transition. Evidence also suggests involvement in worsened cancer treatment outcomes and associations with prognosis and chemoresistance, supporting its clinical relevance as a tumor biomarker and therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/intratumoral-fusobacterium-nucleatum-in-pancreatic-cancer-current-and-future-perspectives-review/331721/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/intratumoral-fusobacterium-nucleatum-in-pancreatic-cancer-current-and-future-perspectives-review/331721.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the focus of the review on Fusobacterium nucleatum in pancreatic cancer?","Question",{"text":112,"@type":113},"The review emphasizes how intratumoral Fusobacterium nucleatum relates to colonization and to oncogenomic changes that contribute to initiation and promotion of pancreatic cancer development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does Fusobacterium nucleatum contribute to pancreatic tumor development and spread?",{"text":117,"@type":113},"It is described as engaging multiple mechanisms, including modulation of immune responses, virulence factor activity, regulation of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition, which can support tumorigenesis and metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is Fusobacterium nucleatum considered clinically important for pancreatic cancer management?",{"text":121,"@type":113},"The review highlights its potential as a prognostic marker and its correlation with chemoresistance, while also presenting it as a possible tumor biomarker and therapeutic target for cancer detection and prognostic assessment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331721,1790411240,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Review  \nIntratumoral Fusobacterium nucleatum in Pancreatic Cancer: Current and Future Perspectives  \nDomenica Lucia D’Antonio 1, Anna Zenoniani 1, Samia Umme 1,2, Adriano Piattelli 3,4  \nand Maria Cristina Curia 1, *  \nAcademic Editor: Jens Kreth  \nReceived: 2 December 2024  \nRevised: 22 December 2024  \nAccepted: 24 December 2024  \nPublished: 26 December 2024  \nCitation: D’Antonio, D.L.; Zenoniani, A.; Umme, S.; Piattelli, A.; Curia, M.C. IntratumoralFusobacterium nucleatumin Pancreatic Cancer: Current and Future Perspectives. Pathogens 2025, 14, 2. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)pathogens14010002  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Medical, Oral and Biotechnological Sciences,“G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy; [domenica.dantonio@unich.it](domenica.dantonio@unich.it) (D.L.D.);  \n[anna.zenoniani@studenti.unich.it](anna.zenoniani@studenti.unich.it) (A.Z.); [ummesamia95@gmail.com](ummesamia95@gmail.com) (S.U.)  \n2 Department of Neuroscience, Imaging and Clinical Sciences,“G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy  \n3 School of Dentistry, Saint Camillus International University of Health and Medical Sciences (UniCamillus), 00131 Rome, Italy; [apiattelli51@gmail.com](apiattelli51@gmail.com)  \n4 Facultad de Medicina, UCAM Universidad Católica San Antonio de Murcia, 30107 Murcia, Spain  \n* [Correspondence: mariacristina.curia@unich.it](Correspondence: mariacristina.curia@unich.it)  \nAbstract: The intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. Fusobacterium nucleatum (Fn), an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. Fn engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. Additionally, compelling research suggests that Fn may exert detrimental effects on cancer treatment outcomes. This paper extends the perspective to pancreatic cancer associated with Fn. The central focus is to unravel the oncogenomic changes driven by Fn in colonization, initiation, and promotion of pancreatic cancer development. The presence of Fusobacterium species can be considered a prognostic marker of PC, and it is also correlated to chemoresistance. Furthermore, this review underscores the clinical research significance of Fn as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. It is thought that given the role of Fn in tumor formation and metastasis processes via its FadA, FapA, Fap2, and RadD, new therapies for tumor treatment targeting Fn will be developed.  \nKeywords: intratumoral microbiota; dysbiosis; fusobacterium nucleatum; oncobacterium; pancreatic cancer; PDAC; Fap2; FadA; TIGIT; RadD  \n1. Microbiota in Healthy Pancreas  \nSeveral studies are being developed on the relationship between the pancreas and host microbiota, consisting of the regulation of immunity and mutual communication [1,2] . Moreover, metabolism, immunity, and nutrition are only some of the examples in which the role of bacteria can be influential","cbCaisDBVnuCZQsw","https://ap.wps.com/l/cbCaisDBVnuCZQsw","pdf",1523317,22,"English","# Abstract\n# Microbiota in Healthy Pancreas","[{\"question\":\"What is the focus of the review on Fusobacterium nucleatum in pancreatic cancer?\",\"answer\":\"The review emphasizes how intratumoral Fusobacterium nucleatum relates to colonization and to oncogenomic changes that contribute to initiation and promotion of pancreatic cancer development.\"},{\"question\":\"How does Fusobacterium nucleatum contribute to pancreatic tumor development and spread?\",\"answer\":\"It is described as engaging multiple mechanisms, including modulation of immune responses, virulence factor activity, regulation of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition, which can support tumorigenesis and metastasis.\"},{\"question\":\"Why is Fusobacterium nucleatum considered clinically important for pancreatic cancer management?\",\"answer\":\"The review highlights its potential as a prognostic marker and its correlation with chemoresistance, while also presenting it as a possible tumor biomarker and therapeutic target for cancer detection and prognostic assessment.\"}]","Intratumoral Fusobacterium nucleatum in Pancreatic Cancer - Current and Future Perspectives - Review | PDF",1789994871,55]