[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-406345-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-406345-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","intrathyroidal-thymic-carcinoma-comprising-squamous-cell-and-small-cell-carcinoma-components-a-case-report","Intrathyroidal thymic carcinoma comprising squamous cell and small cell carcinoma components - A case report","","Intrathyroidal thymic carcinoma (ITC) is a rare malignant epithelial tumour of thymic origin arising within the thyroid. This case report describes a 68-year-old woman with a gradually enlarging left neck mass. Ultrasound identified a 3.9 cm lesion outside the thyroid capsule. Microscopy showed two tumour cell populations: squamous cell carcinoma and small cell carcinoma, supported by immunohistochemical thymic and neuroendocrine markers. Postoperative chemotherapy achieved recurrence-free status at eight months.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/intrathyroidal-thymic-carcinoma-comprising-squamous-cell-and-small-cell-carcinoma-components-a-case-report/406345/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/intrathyroidal-thymic-carcinoma-comprising-squamous-cell-and-small-cell-carcinoma-components-a-case-report/406345.png","ImageObject",300,407,{"name":42,"@type":43},"Bintang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is intrathyroidal thymic carcinoma (ITC) and why is it clinically important?","Question",{"text":63,"@type":64},"ITC is a rare malignant epithelial tumour of thymic origin occurring within the thyroid. Accurate diagnosis matters because it can be mistaken for more aggressive thyroid malignancies, leading to different diagnostic and treatment approaches.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What were the key clinical and imaging findings in the reported case?",{"text":68,"@type":64},"A 68-year-old woman presented with a left-sided neck lump gradually enlarging over one year. Thyroid ultrasound showed a normally sized gland and identified a hypoechoic 3.9 cm × 3.4 cm × 2.7 cm lesion with irregular echogenicity outside the thyroid capsule.",{"name":70,"@type":61,"acceptedAnswer":71},"How did pathology and immunohistochemistry support the diagnosis in this case?",{"text":72,"@type":64},"Microscopy revealed two distinct tumour cell populations: squamous cell carcinoma and small cell carcinoma. Immunohistochemical staining showed divergent differentiation, with one population positive for thymic-associated markers (CD5 and CD117) and the other showing neuroendocrine marker positivity (synaptophysin and chromogranin A).","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},406345,1791248203,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},962085564381,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2025 December 24; 16(12): 111701  \nDOI: 10.5306/wjco.v16.i12.111701 ISSN 2218-4333 (online)  \nCASE REPORT  \nIntrathyroidal thymic carcinoma comprising squamous cell and small cell carcinoma components: A case report  \nBing-Wen Shan, Juan-Han Yu, Tong Ren  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade A  \nP-Reviewer: Xiao Y, MD, PhD, Assistant Professor, China  \nReceived: July 8, 2025  \nRevised: August 24, 2025  \nAccepted: November 14, 2025  \nPublished online: December 24, 2025  \nProcessing time: 168 Days and 13.7 Hours  \nBing-Wen Shan, Juan-Han Yu, Tong Ren, Department of Pathology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China  \nCorresponding author: Juan-Han Yu, MD, Associate Professor, Department of Pathology, The First Hospital of China Medical University, No. 155 Nanjing Bei Ave, Shenyang 110001, Liaoning Province, [China.](China. yujuanhan@foxmail.com)[ yujuanhan@foxmail.com](China. yujuanhan@foxmail.com)  \nAbstract  \nBACKGROUND  \nIntrathyroidal thymic carcinoma (ITC) is a rare malignant epithelial tumour of thymic origin occurring within the thyroid. Histologically, it resembles thymic carcinoma, with squamous cell carcinoma being the most common subtype, and immunohistochemical staining typically exhibits features consistent with thymic neoplasms.  \nCASE SUMMARY  \nWe report the case of a 68-year-old woman who presented with a left-sided neck mass of one year’s duration. And the neck lump had been gradually enlarging over the course of a year, reaching the size of a goose egg within six months. Thyroid ultrasound revealed a normally sized thyroid gland. A 3.9 cm × 3.4 cm × 2.7 cm hypoechoic lesion with irregular echogenicity was observed outside the capsule of the lower pole of the left lobe. The mass exhibited regular morphology, well-defined margins, and close adherence to the thyroid’s lower pole. Microscopic examination revealed two distinct tumour cell populations: Squamous cell carcinoma and small cell carcinoma. Immunohisto-chemical staining demonstrated divergent differentiation-one population was positive for cluster of differentiation 5 and cluster of differentiation 117, supporting thymic origin, while the other exhibited neuroendocrine differentiation with synaptophysin and chromogranin A positivity. At eight months postoperatively, the patient remained recurrence-free on chemotherapy.  \nCONCLUSION  \nBased on these findings, the patient was diagnosed as ITC with both squamous cell and small cell carcinoma components. To date, nearly 100 cases of ITC have been reported in the literature. However, no prior reports of ITC exhibiting both squamous cell and small cell carcinoma components. This case report provides information on the microscopic morphological features of ITC with both squamous cell and small cell carcinoma components, which can help pathologists  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 24, 2025  Volume 16  Issue 12   \nShan BW et al. New pathological manifestations of ITC  \nto expands the understanding of the pathological spectrum of the disease.  \nKey Words: Intrathyroid thymic carcinoma; Carcinoma showing thymus-like differentiation; Neuroendocrine carcinoma; Small cell carcinoma; Case report  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Intrathyroidal thymic carcinoma (ITC) is a rare malignant epithelial tumour of thymic origin occurring within the thyroid. ITC with both squamous cell and small cell carcinoma components has not been repor","cbCailiVUNvARQlc","https://ap.wps.com/l/cbCailiVUNvARQlc","pdf",22327638,"English","# Abstract\n## Background\n## Case Summary\n## Conclusion\n# Introduction\n## Chief complaints\n## History of present illness","[{\"question\":\"What is intrathyroidal thymic carcinoma (ITC) and why is it clinically important?\",\"answer\":\"ITC is a rare malignant epithelial tumour of thymic origin occurring within the thyroid. Accurate diagnosis matters because it can be mistaken for more aggressive thyroid malignancies, leading to different diagnostic and treatment approaches.\"},{\"question\":\"What were the key clinical and imaging findings in the reported case?\",\"answer\":\"A 68-year-old woman presented with a left-sided neck lump gradually enlarging over one year. Thyroid ultrasound showed a normally sized gland and identified a hypoechoic 3.9 cm × 3.4 cm × 2.7 cm lesion with irregular echogenicity outside the thyroid capsule.\"},{\"question\":\"How did pathology and immunohistochemistry support the diagnosis in this case?\",\"answer\":\"Microscopy revealed two distinct tumour cell populations: squamous cell carcinoma and small cell carcinoma. Immunohistochemical staining showed divergent differentiation, with one population positive for thymic-associated markers (CD5 and CD117) and the other showing neuroendocrine marker positivity (synaptophysin and chromogranin A).\"}]","Intrathyroidal thymic carcinoma comprising squamous cell and small cell carcinoma components - A case report | PDF",1790565016,23]