[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-441695-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-441695-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","intrathoracic-manifestations-of-hematologic-malignancies-a-narrative-review","Intrathoracic manifestations of hematologic malignancies: a narrative review","","Intrathoracic manifestations of hematologic malignancies are increasingly important to recognize because non-infectious pulmonary findings can signal disease at presentation or reflect treatment toxicity. This narrative review synthesizes literature on non-infectious intrathoracic pulmonary presentations, emphasizing how these conditions may mimic infection and why management differs substantially from infectious etiologies. The review covers common patterns such as lymphadenopathy, serosal disease, pleural effusions, parenchymal infiltration, and vascular disorders.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/intrathoracic-manifestations-of-hematologic-malignancies-a-narrative-review/441695/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/intrathoracic-manifestations-of-hematologic-malignancies-a-narrative-review/441695.png","ImageObject",300,407,{"name":42,"@type":43},"Sarah ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of this narrative review?","Question",{"text":63,"@type":64},"To summarize current literature on non-infectious intrathoracic manifestations of hematologic malignancies and their treatment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which kinds of intrathoracic pulmonary manifestations are covered?",{"text":68,"@type":64},"The review discusses common findings such as lymphadenopathy and serosal membrane disease, malignant or treatment-related pleural effusions, parenchymal diseases, and intrathoracic vascular disorders.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is prompt recognition of non-infectious pulmonary manifestations important?",{"text":72,"@type":64},"Because these manifestations may mimic infection, and management differs substantially compared with infectious etiologies.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},441695,1791264393,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review Article | Data-Driven Clinical Practice and Policy Making   \nIntrathoracic manifestations of hematologic malignancies: a narrative review  \nKshama Bhyravabhotla 1\\# ^, Gregory Gaskey 1\\# , Jeremy R. Walder 1 ^, Diwakar D. Balachandran2 ^, Sujith V. Cherian1^, Bilal Zafar1, Lara Bashoura2^, Ajay Sheshadri2^, Saadia A. Faiz2^  \n1Division of Pulmonary, Critical Care Medicine and Sleep Medicine, McGovern Medical School at University of Texas Health, Houston, TX, USA; 2Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA  \nContributions: (I) Conception and design: K Bhyravabhotla, G Gaskey, JR Walder, SA Faiz; (II) Administrative support: K Bhyravabhotla, G Gaskey, JR Walder, SA Faiz; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: K Bhyravabhotla, G Gaskey, JR Walder, SA Faiz; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work.  \nCorrespondence to: Saadia A. Faiz, MD. Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Unit 1462, P.O.  \nBox 301402, Houston, 77030-1402, TX, USA. Email: [safaiz@mdanderson.org](safaiz@mdanderson.org).  \nBackground and Objective: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literature on non-infectious intrathoracic  \nmanifestations of hematologic malignancies and their treatment.  \nMethods: We performed a literature review using PubMed Central and Google Scholar for articles published between January 1st, 2014, and January 1st, 2024. We used medical subject heading terms to search titles, abstracts, and diagnoses. We reviewed textbook chapters, literature reviews, practice guidelines,  \nrandomized controlled trials, and retrospective articles.  \nKey Content and Findings: There are many pulmonary manifestations of hematologic malignancies.  \nLymphadenopathy and disease of serosal membranes are common. Pleural effusions can be malignant or related to treatment, and interventions include serial thoracentesis or indwelling pleural catheters (IPCs) .  \nParenchymal diseases consist of primary pulmonary lymphoma, leukemic pulmonary infiltration, myeloid sarcoma, pulmonary alveolar proteinosis, and leukemic cell lysis pneumopathy. Endobronchial disease is rare.  \nPulmonary vascular disorders involve leukostasis, thromboembolic disease, pulmonary hypertension (PH),  \nsuperior vena cava (SVC) syndrome, and pseudohypoxemia. Therapy-related sequelae may also occur.  \nConclusions: Intrathoracic manifestations of hematologic malignancies should be considered in the  \ndifferential diagnosis at the time of presentation since their management differs substantively.  \nKeywords: Hematologic malignancy; pulmonary; malignant pleural effusion (MPE); lymphoma; leukemia  \nSubmitted Sep 16, 2025. Accepted for publication Dec 11, 2025. Published online Dec 24, 2025.  \ndoi: 10.21037/atm-25-139  \nView this article at: [https://dx.doi.org/10.21037/atm-25-139](https://dx.doi.org/10.21037/atm-25-139)  \n^ ORCID: Kshama Bhyravabhotla, 0000-0003-2136-3620; Jeremy R. Walder, 0009-0006-6949-6157; Diwakar D. Balachandran, 0000- 0002-7427-9388; Sujith V. Cherian, 0000-0003-0177-9979; Lara Bashoura, 0000-0003-1126-4039; Ajay Sheshadri, 0000-0002-8091-0180; Saadia A. Faiz, 0000-0001-7284-3945.  \n© AME Publishing Company. Ann Transl Med 2025;13(6):81 | [https://d","cbCaieKWWRPzmJ1B","https://ap.wps.com/l/cbCaieKWWRPzmJ1B","pdf",1029176,15,"English","# Background and Objective\n# Methods\n# Hematologic malignant disease\n## Definitions\n# Key Content and Findings\n# Conclusions","[{\"question\":\"What is the main objective of this narrative review?\",\"answer\":\"To summarize current literature on non-infectious intrathoracic manifestations of hematologic malignancies and their treatment.\"},{\"question\":\"Which kinds of intrathoracic pulmonary manifestations are covered?\",\"answer\":\"The review discusses common findings such as lymphadenopathy and serosal membrane disease, malignant or treatment-related pleural effusions, parenchymal diseases, and intrathoracic vascular disorders.\"},{\"question\":\"Why is prompt recognition of non-infectious pulmonary manifestations important?\",\"answer\":\"Because these manifestations may mimic infection, and management differs substantially compared with infectious etiologies.\"}]","Intrathoracic manifestations of hematologic malignancies: a narrative review | PDF",1790697096,38]